Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Regulatory T Cell Development

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Mitochondrial complex III is essential for suppressive function of regulatory T cells

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Regulatory T cell adaptation in the intestine and skin

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Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

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Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

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mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

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mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

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JunB regulates homeostasis and suppressive functions of effector regulatory T cells

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Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

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An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

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HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

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The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

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Role of Metabolism in the Immunobiology of Regulatory T Cells

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Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

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Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

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Immunometabolism of regulatory T cells

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Analysis of computational footprinting methods for DNase sequencing experiments

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Protein prenylation: unique fats make their mark on biology

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Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

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Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

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The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

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Continuous requirement for the TCR in regulatory T cell function

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Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

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T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

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CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

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mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

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Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells

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Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

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The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

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The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

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The Sequence Alignment/Map format and SAMtools

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Fast and accurate short read alignment with Burrows-Wheeler transform

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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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Model-based Analysis of ChIP-Seq (MACS)

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