Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Functional significance of the platelet immune receptors GPVI and CLEC-2

(2019) Julie Rayes et al.   JOURNAL OF CLINICAL INVESTIGATION

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature

(2017) J. D. Welsh et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Targeting CXCR4-dependent immunosuppressive Ly6Clowmonocytes improves antiangiogenic therapy in colorectal cancer

(2017) Keehoon Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

(2017) Zhongwei Cao et al.   Science Translational Medicine

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

(2016) Kimberly Martinod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

(2016) Zhongwei Cao et al.   NATURE MEDICINE

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration

(2015) Shahin Rafii et al.   NATURE CELL BIOLOGY

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

(2015) Shiri Gur-Cohen et al.   NATURE MEDICINE

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

Translational strategies and challenges in regenerative medicine

(2014) Stefanie Dimmeler et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

(2013) Matija Snuderl et al.   CELL

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

(2013) Yihai Cao   Cell Metabolism

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

(2013) Mariana Toricelli et al.   Molecular Cancer

Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Platelet-macrophage partnership in innate immunity and inflammation

(2013) Alberto Mantovani et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Molecular circuits in thrombosis and inflammation

(2013) Charles Esmon   THROMBOSIS AND HAEMOSTASIS

Regenerative activity of the lung after epithelial injury

(2012) Andrew E. Vaughan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-  signaling

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

(2011) Benjamin Beck et al.   NATURE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Platelets

(2010) Cara C. Bertozzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

(2010) Maija Bry et al.   CIRCULATION

Infusion of mature megakaryocytes into mice yields functional platelets

(2010) Rudy Fuentes et al.   JOURNAL OF CLINICAL INVESTIGATION

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Aggravation of viral hepatitis by platelet-derived serotonin

(2008) Philipp A Lang et al.   NATURE MEDICINE