Roles and mechanisms of BAP1 deubiquitinase in tumor suppression

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

(2020) Tyler M. Bauer et al.   CIRCULATION RESEARCH

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

(2020) Carlos R. Figueiredo et al.   JOURNAL OF PATHOLOGY

Endoplasmic reticulum–plasma membrane contacts: Principals of phosphoinositide and calcium signaling

(2020) Christopher J. Stefan   CURRENT OPINION IN CELL BIOLOGY

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

(2020) Jitendra Badhai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular profiling of driver events in metastatic uveal melanoma

(2020) Joakim Karlsson et al.   Nature Communications

Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer

(2020) Megan E. Tesch et al.   npj Genomic Medicine

PR-DUB maintains expression of critical genes through FOXK1/2 and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

(2020) Petros Kolovos et al.   GENOME RESEARCH

BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

(2020) Stephanie Perkail et al.   Nature Communications

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

BAP1 regulates AMPK-mTOR signalling pathway through deubiquitinating and stabilizing tumour-suppressor LKB1

(2020) Cong Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

(2020) Rong Deng et al.   Molecular Oncology

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

(2019) Antoine Campagne et al.   Nature Communications

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

(2019) Raunak Shrestha et al.   Genome Medicine

Loss of BAP1 as a candidate predictive biomarker for immunotherapy of mesothelioma

(2019) Marc Ladanyi et al.   Genome Medicine

Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

(2019) Yi Huang et al.   Nature Communications

Singing for science

(2019) Mike Z. He   SCIENCE

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

(2019) Anna-Mariya Kukuyan et al.   CANCER RESEARCH

Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution

(2019) Niels J. Brouwer et al.   Cancers

BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers

(2019) Jeffim N. Kuznetsov et al.   Science Advances

BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress

(2019) Han-Sae Lee et al.   BIOCHEMICAL JOURNAL

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis

(2019) Zhen Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion

(2019) Stefan Steurer et al.   Oncotarget

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

(2018) Reina Nagase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

(2018) Lu Wang et al.   NATURE MEDICINE

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma

(2018) Wondossen Sime et al.   Cell Death & Disease

Punctuated evolution of canonical genomic aberrations in uveal melanoma

(2018) Matthew G. Field et al.   Nature Communications

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

(2018) Shuhei Asada et al.   Nature Communications

Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinoma

(2018) Asmaa Mosbeh et al.   Cancer Genetics

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

(2018) Krishna Kalyan Kolluri et al.   eLife

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Cellular Metabolism in Lung Health and Disease

(2018) Gang Liu et al.   Annual Review of Physiology

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

(2018) Lei Yu et al.   GENES & DEVELOPMENT

BAP1 regulates different mechanisms of cell death

(2018) El Bachir Affar et al.   Cell Death & Disease

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

(2018) Salima Daou et al.   Nature Communications

Integrative Molecular Characterization of Malignant Pleural Mesothelioma

(2018) Julija Hmeljak et al.   Cancer Discovery

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

(2018) Lili Liao et al.   eLife

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Germline BAP1 mutations also predispose to cutaneous squamous cell carcinoma

(2017) Robert V. Rawson et al.   PATHOLOGY

BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

(2017) Fangyan Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

(2017) Hyun Goo Woo et al.   Nature Communications

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade

(2017) Yi-Feng Gu et al.   Cancer Discovery

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

(2016) Y. Kadariya et al.   CANCER RESEARCH

Stem Cells: A Renaissance in Human Biology Research

(2016) Jun Wu et al.   CELL

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

(2016) Raphael Bueno et al.   NATURE GENETICS

Loss of BAP1 Expression Is Very Rare in Pancreatic Ductal Adenocarcinoma

(2016) Michael Tayao et al.   PLoS One

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

(2016) Yoshie Yoshikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets

(2016) Ying-Bei Chen et al.   Nature Communications

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

(2016) Danny D. Sahtoe et al.   Nature Communications

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

(2016) Joshua M. Baughman et al.   Cell Reports

The Role of Additional Sex Combs-Like Proteins in Cancer

(2016) Jean-Baptiste Micol et al.   Cold Spring Harbor Perspectives in Medicine

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

(2015) Gauri Bhosale et al.   Annals of the New York Academy of Sciences

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

(2015) Jill A. Ohar et al.   CANCER RESEARCH

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

(2015) Ana Raquel Pengelly et al.   GENES & DEVELOPMENT

BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells

(2015) Hui Pan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

(2015) Salima Daou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT

(2015) Yi Yang et al.   MOLECULAR CELL

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

(2015) Junying Qin et al.   Nature Communications

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex

(2015) Anand Balasubramani et al.   Nature Communications

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

(2015) Michal Kovac et al.   Nature Communications

Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation

(2015) Sushmita Bhattacharya et al.   Scientific Reports

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

(2015) Takashi Izawa et al.   Cell Reports

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s

(2015) Michele Carbone et al.   PLoS Genetics

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

(2014) J. Xu et al.   CANCER RESEARCH

Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma

(2014) G. Guo et al.   CANCER RESEARCH

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

BRCA1-associated Protein 1 (BAP1) Deubiquitinase Antagonizes the Ubiquitin-mediated Activation of FoxK2 Target Genes

(2014) Yuki Okino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O

(2014) Nazar Mashtalir et al.   MOLECULAR CELL

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Plant and animal stem cells: similar yet different

(2014) Renze Heidstra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex

(2014) Zongling Ji et al.   NUCLEIC ACIDS RESEARCH

Bap1is essential for kidney function and cooperates withVhlin renal tumorigenesis

(2014) Shan-Shan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INO80 and SWR complexes: relating structure to function in chromatin remodeling

(2014) Christian B. Gerhold et al.   TRENDS IN CELL BIOLOGY

Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis

(2014) Han-Sae Lee et al.   Nature Communications

Mutations of epigenetic regulatory genes are common in thymic carcinomas

(2014) Yisong Wang et al.   Scientific Reports

Germline BAP1 Mutations Predispose to Renal Cell Carcinomas

(2013) Tatiana Popova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional and cancer genomics of ASXL family members

(2013) M Katoh   BRITISH JOURNAL OF CANCER

A Novel Germline Mutation in BAP1 Predisposes to Familial Clear-Cell Renal Cell Carcinoma

(2013) M. N. Farley et al.   MOLECULAR CANCER RESEARCH

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers

(2012) Eun Mi Je et al.   APMIS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

(2012) Michele Carbone et al.   Journal of Translational Medicine

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Stem cells assessed

(2012) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Germline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families

(2012) Ching-Ni Jenny Njauw et al.   PLoS One

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1

(2011) Francesca Capotosti et al.   CELL

Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers

(2011) M. H. Abdel-Rahman et al.   JOURNAL OF MEDICAL GENETICS

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

(2011) Matthew Bott et al.   NATURE GENETICS

Germline BAP1 mutations and tumor susceptibility

(2011) Alisa M Goldstein   NATURE GENETICS

Germline mutations in BAP1 predispose to melanocytic tumors

(2011) Thomas Wiesner et al.   NATURE GENETICS

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

(2011) S. Daou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia

(2010) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia

(2010) J Boultwood et al.   LEUKEMIA

The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression

(2010) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

(2010) A. S. Revenko et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

(2010) Wen Liu et al.   NATURE

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components

(2010) H. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

(2009) C. L. Fisher et al.   BLOOD

Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia

(2009) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1

(2009) Yuichi J. Machida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1

(2009) S. Misaghi et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency

(2009) Yu Liang et al.   NATURE MEDICINE

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization

(2008) K. H. Ventii et al.   CANCER RESEARCH