BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

(2018) Lu Wang et al.   NATURE MEDICINE

Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines

(2017) M. Wassef et al.   METHODS

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70

(2017) Taosui Li et al.   Epigenetics & Chromatin

Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function

(2017) Lucie Hebert et al.   Oncotarget

Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1

(2016) Ramin Dubey et al.   CANCER RESEARCH

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

(2016) Danny D. Sahtoe et al.   Nature Communications

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

(2015) Xudong Wu et al.   CELL RESEARCH

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

(2015) Robert S. Illingworth et al.   GENES & DEVELOPMENT

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

(2015) Ana Raquel Pengelly et al.   GENES & DEVELOPMENT

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

(2015) Salima Daou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex

(2015) Anand Balasubramani et al.   Nature Communications

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts

(2015) Simona Valletta et al.   Oncotarget

Deubiquitination of  -Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells

(2014) R. Zarrizi et al.   CANCER RESEARCH

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex

(2014) Zongling Ji et al.   NUCLEIC ACIDS RESEARCH

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain

(2014) H. Irem Baymaz et al.   PROTEOMICS

Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis

(2014) Han-Sae Lee et al.   Nature Communications

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

(2013) Katie A Matatall et al.   BMC CANCER

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

(2013) Daichi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

(2012) Omar Abdel-Wahab et al.   CANCER CELL

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

Histone H2A monoubiquitination and Polycomb repression

(2012) Johanna C. Scheuermann et al.   FLY

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

The role of the histone H2A ubiquitinase Sce in Polycomb repression

(2011) L. Gutierrez et al.   DEVELOPMENT

A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer

(2011) Jacob Schwartzman et al.   Epigenetics

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Additional Sex Comb-like (ASXL) Proteins 1 and 2 Play Opposite Roles in Adipogenesis via Reciprocal Regulation of Peroxisome Proliferator-activated Receptor γ

(2010) Ui-Hyun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression

(2010) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice

(2009) C.L. Fisher et al.   DEVELOPMENTAL BIOLOGY

ASXL1 Represses Retinoic Acid Receptor-mediated Transcription through Associating with HP1 and LSD1

(2009) Sang-Wang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1

(2009) Yuichi J. Machida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1

(2009) S. Misaghi et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

(2008) H. Nishikawa et al.   CANCER RESEARCH

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY