Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

(2019) Raunak Shrestha et al.   Genome Medicine

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

(2019) Anna-Mariya Kukuyan et al.   CANCER RESEARCH

Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

(2018) Eleonora Sementino et al.   JOURNAL OF CELLULAR PHYSIOLOGY

seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data

(2018) Ziyi Chen et al.   Frontiers in Immunology

Integrative Molecular Characterization of Malignant Pleural Mesothelioma

(2018) Julija Hmeljak et al.   Cancer Discovery

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

(2016) Y. Kadariya et al.   CANCER RESEARCH

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

(2016) Raphael Bueno et al.   NATURE GENETICS

Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing

(2015) Akihiko Miyanaga et al.   Journal of Thoracic Oncology

High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

(2015) Masaki Nasu et al.   Journal of Thoracic Oncology

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

CopywriteR: DNA copy number detection from off-target sequence data

(2015) Thomas Kuilman et al.   GENOME BIOLOGY

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

(2014) J. Xu et al.   CANCER RESEARCH

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma

(2014) Lindsay A. Marek et al.   MOLECULAR CANCER RESEARCH

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment

(2012) M. Ladanyi et al.   CLINICAL CANCER RESEARCH

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

(2012) Michele Carbone et al.   Journal of Translational Medicine

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

(2011) Matthew Bott et al.   NATURE GENETICS

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

Losses of Both Products of the Cdkn2a/Arf Locus Contribute to Asbestos-Induced Mesothelioma Development and Cooperate to Accelerate Tumorigenesis

(2011) Deborah A. Altomare et al.   PLoS One

ERK2 is essential for the growth of human epithelioid malignant mesotheliomas

(2010) Arti Shukla et al.   INTERNATIONAL JOURNAL OF CANCER

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

A Conditional Mouse Model for Malignant Mesothelioma

(2008) Johan Jongsma et al.   CANCER CELL

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

(2008) M. J. Herold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA