Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 141, Issue 10, Pages 2103-2111Publisher
WILEY
DOI: 10.1002/ijc.30902
Keywords
MiR-21-3p; isoform; colorectal cancer (CRC); epithelial-mesenchymal transition (EMT)
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Funding
- National Natural Science Foundation of China [31471189, 81402724, 31570753]
- National Science Fund for Distinguished Young Scholars [81525020]
- Postdoctoral Scientific Research Aid Program of Jiangsu Province [1501065A]
- Natural Science Foundation of Jiangsu Province [BK20140363, BE2016666, BK20140364]
- Postdoctoral Scientific Research Aid Program of China [2016M590501]
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MiR-21, the only microRNA (miRNA) found to be overexpressed in any type of solid tumor, its guide stand, miR-21-5p, has been studied a lot in colorectal cancer (CRC); however, few researchers focused on its passenger strand, miR-21-3p. In our study, based on The Cancer Genome Atlas (TCGA) data, we found that there were more varieties and quantities of miR-21-3p isoforms in microsatellite instability (MSI)-type CRC. We further examined the role of miR-21-3p by in vitro and in vivo studies. MiR-21-3p may be an oncogene in CRC by promoting cellular mobility through epithelial-mesenchymal transition. However, different isoforms, especially miR-21-3p 0 vertical bar 2 may be a favorable prognostic marker for CRC survival, probably due to increased complementary effect of miR-21-5p and/or target genes. Further study investigating the underlying mechanism of miRNA isoforms is needed.
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