The not-so-sweet side of sugar: Influence of the microenvironment on the processes that unleash cancer

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

(2019) Mam Y. Mboge et al.   BIOCHEMICAL JOURNAL

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

(2019) Ali F. Abdel-Wahab et al.   PHARMACOLOGICAL RESEARCH

Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

(2018) Saori Furuta et al.   eLife

Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

(2018) Benjamin L Ricca et al.   eLife

Quantitative Proteomic Analysis of 2D and 3D Cultured Colorectal Cancer Cells: Profiling of Tankyrase Inhibitor XAV939-Induced Proteome

(2018) Young Eun Kim et al.   Scientific Reports

Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling

(2018) Gentry K. Cork et al.   Frontiers in Endocrinology

FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach

(2017) Antoine M. Snijders et al.   Molecular Oncology

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH

(2017) Laurent Schwartz et al.   SEMINARS IN CANCER BIOLOGY

Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma

(2017) Xiao-Long Li et al.   Scientific Reports

Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect

(2016) Xi-sha Chen et al.   ACTA PHARMACOLOGICA SINICA

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells

(2016) B Chaube et al.   Cell Death & Disease

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

(2016) Suraj Peri et al.   Oncotarget

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells

(2015) Stuti Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

(2015) Jayasri Nanduri et al.   PLoS One

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer

(2014) Britta Weigelt et al.   ADVANCED DRUG DELIVERY REVIEWS

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Cancer as a metabolic disease: implications for novel therapeutics

(2013) T. N. Seyfried et al.   CARCINOGENESIS

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

(2013) Yasuhito Onodera et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin  1

(2012) H. Mori et al.   DEVELOPMENT

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice

(2012) Sun-Young Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constructing Three-Dimensional Models to Study Mammary Gland Branching Morphogenesis and Functional Differentiation

(2012) Alvin T. Lo et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin

(2011) Osvaldo Pontiggia et al.   BREAST CANCER RESEARCH AND TREATMENT

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations

(2010) A. Bellacosa et al.   Cancer Prevention Research

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

(2010) Giulio Zuccoli et al.   Nutrition & Metabolism

Oxygen-Controlled Three-Dimensional Cultures to Analyze Tumor Angiogenesis

(2010) Scott S. Verbridge et al.   TISSUE ENGINEERING PART A

Molecular Predictors of 3D Morphogenesis by Breast Cancer Cell Lines in 3D Culture

(2010) Ju Han et al.   PLoS Computational Biology

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy

(2009) BS Dwarakanath et al.   Future Oncology

Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

(2009) A. Siddiq et al.   JOURNAL OF NEUROSCIENCE

Inhibition of vimentin or  1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

(2009) X. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Sp1 Is Required for Glucose-Induced Transcriptional Regulation of Mouse Vesicular Glutamate Transporter 2 Gene

(2008) Tao Li et al.   GASTROENTEROLOGY

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

(2008) Purna Mukherjee et al.   Molecular Cancer

Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression

(2008) Celeste M Nelson et al.   Nature Protocols