Cancer as a metabolic disease: implications for novel therapeutics

The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions

(2015) Martin Michaelis et al.   NEOPLASIA

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of p90RSKin regulating the Crabtree effect: implications for cancer

(2013) Emily K. Redman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts

(2013) B. G. Allen et al.   CLINICAL CANCER RESEARCH

Selectively starving cancer cells through dietary manipulation: methods and clinical implications

(2013) Brittany A Simone et al.   Future Oncology

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Caloric restriction reduces edema and prolongs survival in a mouse glioma model

(2013) Yong-Sheng Jiang et al.   JOURNAL OF NEURO-ONCOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Survival in Patients with Glioblastoma Receiving Valganciclovir

(2013) Cecilia Söderberg-Nauclér et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

(2013) Benny Abraham Kaipparettu et al.   PLoS One

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

(2013) Rossitza Lazova et al.   PLoS One

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

(2013) Angela M. Poff et al.   PLoS One

Grappling with Cancer

(2013) E. T. Liu   SCIENCE

Steering Cancer Genomics Into the Fast Lane

(2013) E. Pennisi   SCIENCE

Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed

(2013) H. L. McLeod   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity

(2012) R. L. Elliott et al.   BREAST CANCER RESEARCH AND TREATMENT

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Is systems biology a promising approach to resolve controversies in cancer research?

(2012) Ana M Soto et al.   Cancer Cell International

Mitochondrial regulation of epigenetics and its role in human diseases

(2012) Sheroy Minocherhomji et al.   Epigenetics

Composition of molecular cardiolipin species correlates with proliferation of lymphocytes

(2012) Lorenz Schild et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Availability, not respiratory capacity governs oxygen consumption of solid tumors

(2012) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The bio-energetic theory of carcinogenesis

(2012) Michael J. Gonzalez et al.   MEDICAL HYPOTHESES

Seeing the Warburg effect in the developing retina

(2012) Brian P. Fiske et al.   NATURE CELL BIOLOGY

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Consensus on the role of human cytomegalovirus in glioblastoma

(2012) K. Dziurzynski et al.   NEURO-ONCOLOGY

Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients

(2012) Eugene J. Fine et al.   NUTRITION

The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma

(2012) Mohammed G. Abdelwahab et al.   PLoS One

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

(2012) Weiqin Lu et al.   PLOS BIOLOGY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

(2011) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

(2011) Gabriele D Maurer et al.   BMC CANCER

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Fusion between Intestinal Epithelial Cells and Macrophages in a Cancer Context Results in Nuclear Reprogramming

(2011) Anne E. Powell et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

K-Ras and mitochondria: Dangerous liaisons

(2011) Jiri Neuzil et al.   CELL RESEARCH

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype

(2011) K. Dziurzynski et al.   CLINICAL CANCER RESEARCH

Editorial (Another Year of Prosperity for Current Molecular Medicine)

(2011) David W. Li   CURRENT MOLECULAR MEDICINE

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?

(2011) Thomas N. Seyfried et al.   EPILEPSY RESEARCH

Mitochondrial Dysfunction in Cancer Cells Due to Aberrant Mitochondrial Replication

(2011) Yuriy Shapovalov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Influence of Caloric Restriction on Constitutive Expression of NF-κB in an Experimental Mouse Astrocytoma

(2011) Tiernan J. Mulrooney et al.   PLoS One

Exploring the Genomes of Cancer Cells: Progress and Promise

(2011) M. R. Stratton   SCIENCE

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53, Aerobic Metabolism, and Cancer

(2010) Cory U. Lago et al.   ANTIOXIDANTS & REDOX SIGNALING

Is Lamarckian evolution relevant to medicine?

(2010) Adam E Handel et al.   BMC Medical Genetics

Perspectives on the mesenchymal origin of metastatic cancer

(2010) Leanne C. Huysentruyt et al.   CANCER AND METASTASIS REVIEWS

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L

(2010) Dianer Yang et al.   CANCER BIOLOGY & THERAPY

Finding an “Achilles’ heel” of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells

(2010) Mariia Yuneva   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Biologically Targeted Cancer Therapy and Marginal Benefits: Are We Making Too Much of Too Little or Are We Achieving Too Little by Giving Too Much?

(2010) T. Fojo et al.   CLINICAL CANCER RESEARCH

Cancer metabolism: The Warburg effect today

(2010) Leonardo M.R. Ferreira   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

(2010) Christos Chinopoulos et al.   FASEB JOURNAL

Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model

(2010) Laura M. Shelton et al.   INTERNATIONAL JOURNAL OF CANCER

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Trafficking of UL37 Proteins into Mitochondrion-Associated Membranes during Permissive Human Cytomegalovirus Infection

(2010) P. Bozidis et al.   JOURNAL OF VIROLOGY

Does the existing standard of care increase glioblastoma energy metabolism?

(2010) Thomas N Seyfried et al.   LANCET ONCOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

(2010) Giulio Zuccoli et al.   Nutrition & Metabolism

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Evidence for Mitochondrial Respiratory Deficiency in Rat Rhabdomyosarcoma Cells

(2010) Vanessa E. Jahnke et al.   PLoS One

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance

(2010) David Tarin   SEMINARS IN CANCER BIOLOGY

Mutational Heterogeneity in Human Cancers: Origin and Consequences

(2009) Jesse J. Salk et al.   Annual Review of Pathology-Mechanisms of Disease

Succinyl-CoA Synthetase Is a Phosphate Target for the Activation of Mitochondrial Metabolism

(2009) Darci Phillips et al.   BIOCHEMISTRY

Is evolution Darwinian or/and Lamarckian?

(2009) Eugene V Koonin et al.   Biology Direct

Electron microscopy morphology of the mitochondrial network in human cancer

(2009) Gabriel Arismendi-Morillo   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ketone bodies inhibit the viability of human neuroblastoma cells

(2009) Robert Skinner et al.   JOURNAL OF PEDIATRIC SURGERY

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

(2009) Ad JC de Groof et al.   Molecular Cancer

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Customized Treatment in Non-Small-Cell Lung Cancer Based on EGFR Mutations and BRCA1 mRNA Expression

(2009) Rafael Rosell et al.   PLoS One

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect

(2009) Yijun Chen et al.   PLoS One

Access of viral proteins to mitochondria via mitochondria-associated membranes

(2009) Chad D. Williamson et al.   REVIEWS IN MEDICAL VIROLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Ultrastructure of the Mitochondrion and Its Bearing on Function and Bioenergetics

(2008) Giovanni Benard et al.   ANTIOXIDANTS & REDOX SIGNALING

Akt-Dependent Proapoptotic Effects of Dietary Restriction on Late-Stage Management of a Phosphatase and Tensin Homologue/Tuberous Sclerosis Complex 2-Deficient Mouse Astrocytoma

(2008) J. Marsh et al.   CLINICAL CANCER RESEARCH

Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets

(2008) Thomas N. Seyfried et al.   EPILEPSIA

Metastatic cancer cells with macrophage properties: Evidence from a new murine tumor model

(2008) Leanne C. Huysentruyt et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondrial Oxidative Phosphorylation Is Regulated by Fructose 1,6-Bisphosphate

(2008) Rodrigo Díaz-Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

(2008) Michael A. Kiebish et al.   JOURNAL OF LIPID RESEARCH

Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet

(2008) Jeremy Marsh et al.   Nutrition & Metabolism

Glutamine prevents DMBA-induced squamous cell cancer

(2008) V. Lim et al.   ORAL ONCOLOGY

Press-pulse: a general theory of mass extinction?

(2008) Nan Crystal Arens et al.   PALEOBIOLOGY

Acidic lipids, H+-ATPases, and mechanism of oxidative phosphorylation. Physico-chemical ideas 30 years after P. Mitchell's Nobel Prize award

(2008) Nikolai Kocherginsky   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY