Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway

Chemical analysis of saffron by HPLC based crocetin estimation

(2020) Chilakala Nagarjuna Reddy et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Sex-driven modifiers of Alzheimer risk

(2020) Aneela Rahman et al.   NEUROLOGY

Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

(2020) Devin Kepchia et al.   Alzheimers Research & Therapy

The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models

(2019) Ioanna Chalatsa et al.   Frontiers in Neuroscience

Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

(2019) Abubakar Wani et al.   Autophagy

Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness

(2019) Si Eun Kim et al.   NEUROLOGY

Metformin reduces prion infection in neuronal cells by enhancing autophagy

(2019) Dalia H. Abdelaziz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

(2018) Stefano Thellung et al.   Cell Death & Disease

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

(2018) Erin E. Congdon   Frontiers in Neuroscience

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

(2018) Jin Zhang et al.   Immunity & Ageing

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

(2017) Mohammad Ejaz Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation

(2017) Lourdes Álvarez-Arellano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Trans -crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients

(2017) Roberto Tiribuzi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury

(2017) Xiqian Wang et al.   Neuroscience Bulletin

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

(2017) Tibor Kovács et al.   Scientific Reports

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

(2016) Carolin Walter et al.   NEUROPHARMACOLOGY

Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

(2016) So Youn Park et al.   PLoS One

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

(2016) Stjepko Cermak et al.   PLoS One

The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury

(2016) Chuan-fang Wang et al.   Scientific Reports

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier

(2015) M. Lautenschläger et al.   PHYTOMEDICINE

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Improving the prediction of drug disposition in the brain

(2013) Kiril Lanevskij et al.   Expert Opinion on Drug Metabolism & Toxicology

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain

(2011) Fumihiko Yoshino et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices

(2011) F. Berger et al.   NEUROSCIENCE

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE