The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models

Beneficial Effects of Sideritis scardica and Cichorium spinosum against Amyloidogenic Pathway and Tau Misprocessing in Alzheimer’s Disease Neuronal Cell Culture Models

(2018) Ioanna Chalatsa et al.   JOURNAL OF ALZHEIMERS DISEASE

LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

(2018) Eloise Ferreira et al.   Oncotarget

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Downregulation of AβPP Enhances Both Calcium Content of Endoplasmic Reticulum and Acidic Stores and the Dynamics of Store Operated Calcium Channel Activity

(2018) Maria Chatzistavraki et al.   JOURNAL OF ALZHEIMERS DISEASE

A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease

(2017) John W. Finley et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils

(2017) Eiji Inoue et al.   Journal of Natural Medicines

Trans -crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients

(2017) Roberto Tiribuzi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer’s Disease

(2017) Ni-Chung Lee et al.   Frontiers in Aging Neuroscience

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study

(2016) Stephen B. Wharton et al.   Acta Neuropathologica Communications

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

(2015) Farideh Asadi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier

(2015) M. Lautenschläger et al.   PHYTOMEDICINE

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model.

(2014) M Bond et al.   HEALTH TECHNOLOGY ASSESSMENT

Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

(2014) Lan Zhang et al.   International Journal of Biological Sciences

Dose-Dependent Inhibition of BACE-1 by the Monoterpenoid 2,3,4,4-Tetramethyl-5-methylenecyclopent-2-enone in Cellular and Mouse Models of Alzheimer’s Disease

(2014) Rita Videira et al.   JOURNAL OF NATURAL PRODUCTS

Crocetin, a Carotenoid Derived from Saffron (Crocus sativus L.), Improves Acetylcholine-Induced Vascular Relaxation in Hypertension

(2014) Andrea Mancini et al.   JOURNAL OF VASCULAR RESEARCH

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain

(2013) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Biological function of Presenilin and its role in AD pathogenesis

(2013) Shuting Zhang et al.   Translational Neurodegeneration

CSF Presenilin-1 complexes are increased in Alzheimer’s disease

(2013) María-Salud García-Ayllón et al.   Acta Neuropathologica Communications

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Store-operated Ca2+ entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells

(2012) Natalie Bell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   Current Alzheimer Research

Mechanisms of the Effects of Crocin on Aggregation and Deposition of Aβ1–40 Fibrils in Alzheimer’s Disease

(2012) Arezou Ghahghaei et al.   International Journal of Peptide Research and Therapeutics

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

(2012) Jemila Houacine et al.   NEUROBIOLOGY OF AGING

Comparison of different tandem mass spectrometric techniques (ESI-IT, ESI- and IP-MALDI-QRTOF and vMALDI-TOF/RTOF) for the analysis of crocins and picrocrocin from the stigmas of Crocus sativus L.

(2012) Nikolaos Stavros Koulakiotis et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity

(2012) Hui Wang et al.   NEURAL PLASTICITY

Advances in the Pathogenesis of Alzheimer’s Disease: Focusing on Tau-Mediated Neurodegeneration

(2012) Yale Duan et al.   Translational Neurodegeneration

Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers

(2011) Joon Ho Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Phytochemicals in the Treatment and Prevention of Dementia

(2011) Melanie-Jayne R. Howes et al.   DRUGS & AGING

Intraneuronal APP, Not Free A  Peptides in 3xTg-AD Mice: Implications for Tau versus A -Mediated Alzheimer Neurodegeneration

(2011) M. J. Winton et al.   JOURNAL OF NEUROSCIENCE

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

(2011) Johannes Prox et al.   EXPERIMENTAL BRAIN RESEARCH

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New Applications and Mechanisms of Action of Saffron and its Important Ingredients

(2010) S. Zahra Bathaie et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

(2010) Kyong Nyon Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease

(2010) Orestes V. Forlenza et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Timing-Dependent Actions of NGF Required for Cell Differentiation

(2010) Jaehoon Chung et al.   PLoS One

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease

(2009) Sofia Jürgensen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

(2009) Shahin Akhondzadeh et al.   PSYCHOPHARMACOLOGY

Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau

(2008) Ioannis Sotiropoulos et al.   JOURNAL OF NEUROCHEMISTRY

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study

(2008) P Lewczuk et al.   MOLECULAR PSYCHIATRY

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY