Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

(2015) Ryan P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of lysosomal Npc1-binding proteins: Cathepsin D activity is regulated by NPC1

(2015) Judit Macías-Vidal et al.   PROTEOMICS

Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

(2015) Minjeong Jung et al.   PLoS One

Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease

(2014) Martina Malnar et al.   NEUROBIOLOGY OF DISEASE

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

(2013) Stefan Tholen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of cathepsins B and L in inflammation and cholesterol trafficking protein NPC2 secretion in macrophages

(2013) Jennifer Hannaford et al.   Obesity

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

(2012) Martina Malnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein

(2012) Xueyun Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer’s disease

(2011) Israel Schechter et al.   BIOLOGICAL CHEMISTRY

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

(2011) David Butler et al.   PLoS One

Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway

(2010) Martina Malnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased Activity and Altered Subcellular Distribution of Lysosomal Enzymes Determine Neuronal Vulnerability in Niemann-Pick Type C1-Deficient Mice

(2009) Asha Amritraj et al.   AMERICAN JOURNAL OF PATHOLOGY