Journey to a Receptor for Advanced Glycation End Products Connection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

(2020) Jin-jin Zhang et al.   ALLERGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology

(2020) Simon J. Cleary et al.   BRITISH JOURNAL OF PHARMACOLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits

(2020) Shitao Rao et al.   DIABETES CARE

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

(2020) Luka Nicin et al.   EUROPEAN HEART JOURNAL

Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

(2020) Gregorio Tersalvi et al.   JOURNAL OF CARDIAC FAILURE

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

The protein S100A4 as a novel marker of insulin resistance in prepubertal and pubertal children with obesity

(2020) Augusto Anguita-Ruiz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

(2020) Ulf Andersson et al.   MOLECULAR MEDICINE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

(2020) Paul MacDaragh Ryan et al.   Obesity

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

Prevalence and impact of diabetes among people infected with SARS-CoV-2

(2020) G. P. Fadini et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

COVID-19 and the Heart and Vasculature

(2020) Bernard S. Kadosh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses

(2020) Nigel Mackman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

(2020) Liting Chen et al.   Cellular & Molecular Immunology

SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes

(2020) Alexander G. Obukhov et al.   DIABETES

Hyperglycemia at Hospital Admission Is Associated With Severity of the Prognosis in Patients Hospitalized for COVID-19: The Pisa COVID-19 Study

(2020) Alberto Coppelli et al.   DIABETES CARE

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019

(2020) Melvin R. Hayden   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment

(2020) Sebastiano Cicco et al.   MEDIATORS OF INFLAMMATION

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism

(2020) Laura Senatus et al.   JCI Insight

Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19

(2020) Jeffrey S. Berger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

(2020) Denisa Bojkova et al.   CARDIOVASCULAR RESEARCH

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City

(2020) Alain C. Borczuk et al.   MODERN PATHOLOGY

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses

(2020) Israel Júnior Borges do Nascimento et al.   PLoS One

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

(2020) Meng Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

COVID-19 can affect the heart

(2020) Eric J. Topol   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

(2020) Ilja L Kruglikov et al.   eLife

AGE–RAGE stress: a changing landscape in pathology and treatment of Alzheimer’s disease

(2019) Kailash Prasad   MOLECULAR AND CELLULAR BIOCHEMISTRY

S100 proteins in obesity: liaisons dangereuses

(2019) Francesca Riuzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of Advanced Glycation Endproduct (AGE)-Receptor for Advanced Glycation Endproduct (RAGE) Axis in Cardiovascular Disease and Its Therapeutic Intervention

(2019) Sho-ichi Yamagishi   CIRCULATION JOURNAL

A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

(2019) Carmen Hurtado del Pozo et al.   Cell Reports

RAGE and CCR7 mediate the transmigration of Zika-infected monocytes through the blood-brain barrier

(2019) Gabriel Costa de Carvalho et al.   IMMUNOBIOLOGY

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

(2018) Brian A. Boone et al.   BMC CANCER

Neutrophil extracellular traps promote macrophage pyroptosis in sepsis

(2018) Linsong Chen et al.   Cell Death & Disease

Newcastle disease virus infection triggers HMGB1 release to promote the inflammatory response

(2018) Yurong Qu et al.   VIROLOGY

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

(2018) Raelene J. Pickering et al.   JOURNAL OF CLINICAL INVESTIGATION

Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function

(2017) Torey R. Arnold et al.   EXPERIMENTAL CELL RESEARCH

HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity

(2017) Jing Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Renin-Angiotensin System in Diabetes

(2017) Johannes Rein et al.   PROTEIN AND PEPTIDE LETTERS

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

(2017) Jaisy Arikkatt et al.   eLife

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

(2017) Carlene Petes et al.   Frontiers in Immunology

The Formin, DIAPH1, is a Key Modulator of Myocardial Ischemia/Reperfusion Injury

(2017) Karen M. O'Shea et al.   EBioMedicine

Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure

(2017) Erin J. Caraher et al.   PLoS One

RAGE inhibition reduces acute lung injury in mice

(2017) Raiko Blondonnet et al.   Scientific Reports

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

(2016) K. Stark et al.   BLOOD

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Glycation & the RAGE axis: targeting signal transduction through DIAPH1

(2016) Alexander Shekhtman et al.   Expert Review of Proteomics

Pathways of the Maillard reaction under physiological conditions

(2016) Christian Henning et al.   GLYCOCONJUGATE JOURNAL

RAGE Enhances TLR Responses through Binding and Internalization of RNA

(2016) Damien Bertheloot et al.   JOURNAL OF IMMUNOLOGY

Soluble receptor for advanced glycation end products mitigates vascular dysfunction in spontaneously hypertensive rats

(2016) Yu Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Endothelial RAGE exacerbates acute postischaemic cardiac inflammation

(2016) Tilman Ziegler et al.   THROMBOSIS AND HAEMOSTASIS

Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction

(2016) Michaele B. Manigrasso et al.   Scientific Reports

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro

(2016) Suzanne Miller et al.   PLoS One

Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease

(2015) Guang-Nian Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

Emerging Targets for Therapeutic Development in Diabetes and Its Complications: The RAGE Signaling Pathway

(2015) EMS Litwinoff et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Adaptive evolution of the MHC class III-encoded receptor RAGE in primates and murine rodents

(2015) X. Wu et al.   International Journal of Immunogenetics

Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China

(2015) Hang Wang et al.   PLoS One

Critical role of RAGE and HMGB1 in inflammatory heart disease

(2015) Anna Bangert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble RAGEs — Prospects for treating & tracking metabolic and inflammatory disease

(2015) Ann Marie Schmidt   VASCULAR PHARMACOLOGY

Dietary Advanced Glycation End Products and Their Role in Health and Disease

(2015) Jaime Uribarri et al.   Advances in Nutrition

N ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

(2014) Katrien H.J. Gaens et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blocking the Receptor for Advanced Glycation End Product Activation Attenuates Autoimmune Myocarditis

(2014) Woo-In Yang et al.   CIRCULATION JOURNAL

RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice

(2014) Fei Song et al.   DIABETES

S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways

(2014) Jin Hyun Kang et al.   IMMUNOLOGY

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

(2014) R Guzmán-Ruiz et al.   INTERNATIONAL JOURNAL OF OBESITY

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Receptor for Advanced Glycation End-Products (RAGE) Is Only Present in Mammals, and Belongs to a Family of Cell Adhesion Molecules (CAMs)

(2014) Luca Sessa et al.   PLoS One

Interferon Regulatory Factor 7 Protects Against Vascular Smooth Muscle Cell Proliferation and Neointima Formation

(2014) Ling Huang et al.   Journal of the American Heart Association

Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications

(2013) Vaibhav B. Patel et al.   CLINICAL SCIENCE

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

(2013) Cherilyn M. Sirois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combinatorial Library of Improved Peptide Aptamers, CLIPs to Inhibit RAGE Signal Transduction in Mammalian Cells

(2013) Sergey Reverdatto et al.   PLoS One

RAGE binds C1q and enhances C1q-mediated phagocytosis

(2012) Wanchao Ma et al.   CELLULAR IMMUNOLOGY

Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative and Signal Transduction Pathways

(2012) Fatouma Touré et al.   CIRCULATION RESEARCH

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

(2012) Chris Tikellis et al.   CLINICAL SCIENCE

Higher plasma high-mobility group box 1 levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12 year follow-up study

(2012) J. W. M. Nin et al.   DIABETOLOGIA

Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling

(2012) Vivek Rai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Opposing Roles of Membrane and Soluble Forms of the Receptor for Advanced Glycation End Products in Primary Respiratory Syncytial Virus Infection

(2012) Allison L. Miller et al.   JOURNAL OF INFECTIOUS DISEASES

AGER -429T/C Is Associated with an Increased Lung Disease Severity in Cystic Fibrosis

(2012) Julie Beucher et al.   PLoS One

Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation

(2012) STEPHANIE T. YERKOVICH et al.   RESPIROLOGY

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

Signal Transduction in Receptor for Advanced Glycation End Products (RAGE)

(2011) Vivek Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis

(2011) Katrien H.J. Gaens et al.   JOURNAL OF HEPATOLOGY

Advanced Glycation End Product Recognition by the Receptor for AGEs

(2011) Jing Xue et al.   STRUCTURE

Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging

(2010) Shi Fang Yan et al.   BIOCHEMICAL PHARMACOLOGY

Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling and Up-regulation of Egr-1 in Hypoxic Macrophages

(2010) Yunlu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association between H1N1 Infection Severity and Obesity—Adiponectin as a Potential Etiologic Factor

(2010) C. Tsatsanis et al.   JOURNAL OF INFECTIOUS DISEASES

RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways

(2010) Linshan Shang et al.   PLoS One

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis

(2009) David A Hughes et al.   BMC EVOLUTIONARY BIOLOGY

Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia

(2009) Marieke A.D van Zoelen et al.   VIROLOGY

RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model

(2008) Alexey Aleshin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet

(2008) Manisha Gupte et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Formins in cell signaling

(2008) Kevin G. Young et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

(2008) L. G. Bucciarelli et al.   DIABETES

Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42

(2008) Barry I. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION