S100 proteins in obesity: liaisons dangereuses

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat

(2019) Christopher D. Kassotis et al.   Frontiers in Endocrinology

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy

(2019) Jens Juul Holst   Frontiers in Endocrinology

Mechanism of Glucagon-Like Peptide 1 Improvements in Type 2 Diabetes Mellitus and Obesity

(2019) Eric Nolen-Doerr et al.   Current Obesity Reports

Association of S100B Serum Levels with Metabolic Syndrome and its Components

(2018) Sorayya Kheirouri et al.   Acta Medica Portuguesa

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Incretin hormones: Their role in health and disease

(2018) Michael A. Nauck et al.   DIABETES OBESITY & METABOLISM

Screening of potential adipokines identifies S100A4 as a marker of pernicious adipose tissue and insulin resistance

(2018) Peter Arner et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation

(2018) Petra Kotzbeck et al.   JOURNAL OF LIPID RESEARCH

S100A4 protects mice from high-fat diet-induced obesity and inflammation

(2018) Shasha Hou et al.   LABORATORY INVESTIGATION

Food Intake and Eating Behavior After Bariatric Surgery

(2018) Werd Al-Najim et al.   PHYSIOLOGICAL REVIEWS

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis

(2018) Rohollah Babaei et al.   Science Signaling

High Glycemic Index Metabolic Damage – a Pivotal Role of GIP and GLP-1

(2018) Andreas F.H. Pfeiffer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival

(2018) Stanislava Pankratova et al.   Theranostics

Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis

(2018) Rohollah Babaei et al.   Science Signaling

S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

S100 proteins in rheumatic diseases

(2018) Judith Austermann et al.   Nature Reviews Rheumatology

FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis

(2018) Rui Zhang et al.   PLOS BIOLOGY

The chemokine system and its role in obesity

(2018) Wenhua Xue et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Obesity and cardiovascular disease: revisiting an old relationship

(2018) Chrysi Koliaki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The obese adipose tissue microenvironment in cancer development and progression

(2018) Daniela F. Quail et al.   Nature Reviews Endocrinology

Cellular and molecular mechanisms of sarcopenia: the S100B perspective

(2018) Francesca Riuzzi et al.   Journal of Cachexia Sarcopenia and Muscle

The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance

(2017) Mariana P. Monteiro et al.   GASTROENTEROLOGY

HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity

(2017) Jing Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity

(2017) Omar Al Massadi et al.   TRENDS IN NEUROSCIENCES

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Expression of Calgranulin Genes S100A8, S100A9 and S100A12 Is Modulated by n-3 PUFA during Inflammation in Adipose Tissue and Mononuclear Cells

(2017) Rachana D. Shah et al.   PLoS One

Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy

(2017) Francesca Riuzzi et al.   Scientific Reports

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Age-related accumulation of advanced glycation end-products-albumin, S100β, and the expressions of advanced glycation end product receptor differ in visceral and subcutaneous fat

(2016) Kuk Hui Son et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular mechanisms and consequences of glycation in atherosclerosis and obesity

(2016) Raquel López- Díez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human brain responses to gastrointestinal nutrients and gut hormones

(2016) John T McLaughlin et al.   CURRENT OPINION IN PHARMACOLOGY

S100A7: A rAMPing up AMP molecule in psoriasis

(2016) Fabio D’Amico et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tonsil-Derived Mesenchymal Stem Cells Differentiate into a Schwann Cell Phenotype and Promote Peripheral Nerve Regeneration

(2016) Namhee Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation

(2016) Abigail S. Haka et al.   JOURNAL OF LIPID RESEARCH

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

S100B suppresses the differentiation of C3H/10T1/2 murine embryonic mesenchymal cells into osteoblasts

(2016) Dong Li et al.   Molecular Medicine Reports

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

S100A8/A9: From basic science to clinical application

(2016) Monika Pruenster et al.   PHARMACOLOGY & THERAPEUTICS

S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53

(2016) Tao Yang et al.   STEM CELLS

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease

(2015) Ravichandran Ramasamy et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative Stress and Adipocyte Biology: Focus on the Role of AGEs

(2015) Florence Boyer et al.   Oxidative Medicine and Cellular Longevity

Visualized macrophage dynamics and significance of S100A8 in obese fat

(2015) Ryohei Sekimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity

(2015) Kelly Bowden-Davies et al.   PROTEOMICS

S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells

(2015) ELENA CAPOCCIA et al.   Oncology Letters

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation

(2014) Chen Varol et al.   JOURNAL OF IMMUNOLOGY

Estrogen suppresses adipogenesis by inhibiting S100A16 expression

(2014) Rihua Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Thermogenic adipocytes: From cells to physiology and medicine

(2014) Mauricio Berriel Diaz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Differentiation of Schwann-like cells from human umbilical cord blood mesenchymal stem cells in vitro

(2014) YU-ZHOU XIAO et al.   Molecular Medicine Reports

Regulation of S100B in white adipose tissue by obesity in mice

(2014) Laura B Buckman et al.   Adipocyte

Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome)

(2013) Masaya Yamaoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Joining S100 proteins and migration: for better or for worse, in sickness and in health

(2013) Stephane R. Gross et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity

(2013) Katrien HJ. Gaens et al.   CURRENT OPINION IN LIPIDOLOGY

Psoriasin: A Novel Marker Linked Obesity with Psoriasis

(2013) Ragaa H. M. Salama et al.   DISEASE MARKERS

S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease

(2013) Alexandru Schiopu et al.   MEDIATORS OF INFLAMMATION

S100A16 inhibits osteogenesis but stimulates adipogenesis

(2013) Dong Li et al.   MOLECULAR BIOLOGY REPORTS

The role of S100B in the interaction between adipocytes and macrophages

(2013) Atsushi Fujiya et al.   Obesity

High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice

(2012) Ryohei Sekimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

(2012) Khanh-Van Tran et al.   Cell Metabolism

Functions of S100 Proteins

(2012) R. Donato et al.   CURRENT MOLECULAR MEDICINE

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice: Involvement of Toll-Like Receptor 2

(2012) M. Monden et al.   DIABETES

Global obesity: trends, risk factors and policy implications

(2012) Vasanti S. Malik et al.   Nature Reviews Endocrinology

The adipose organ: white-brown adipocyte plasticity and metabolic inflammation

(2012) A. Smorlesi et al.   Obesity Reviews

GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis

(2012) Su-Jin Kim et al.   PLoS One

The metastasis-promoting S100A4 protein confers neuroprotection in brain injury

(2012) Oksana Dmytriyeva et al.   Nature Communications

S100A8 and S100A9 in Cardiovascular Biology and Disease

(2011) Michelle M. Averill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transgenic expression of human S100A12 induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation

(2011) M. A. Hofmann Bowman et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11 -Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

(2011) O. Gogebakan et al.   DIABETES

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans

(2011) M. Christensen et al.   DIABETES

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

(2011) Kathrin Eller et al.   DIABETES

Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells

(2011) Yun Liu et al.   ENDOCRINOLOGY

S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner

(2011) F. Riuzzi et al.   JOURNAL OF CELL SCIENCE

S100A16 mediation of weight gain attenuation induced by dietary calcium

(2011) Rihua Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

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(2011) Victoria Catalan et al.   MOLECULAR MEDICINE

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

(2011) Guglielmo Sorci et al.   PLoS Pathogens

Human muscle satellite cells show age-related differential expression of S100B protein and RAGE

(2010) Sara Beccafico et al.   AGE

Inflammation-associated S100 proteins: new mechanisms that regulate function

(2010) Jesse Goyette et al.   AMINO ACIDS

Oxidative Modifications of DAMPs Suppress Inflammation: The Case for S100A8 and S100A9

(2010) Su Yin Lim et al.   ANTIOXIDANTS & REDOX SIGNALING

S100B in myoblasts regulates the transition from activation to quiescence and from quiescence to activation and reduces apoptosis

(2010) Claudia Tubaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interaction of Developmental Transcription Factor HOXC11 with Steroid Receptor Coactivator SRC-1 Mediates Resistance to Endocrine Therapy in Breast Cancer

(2010) M. McIlroy et al.   CANCER RESEARCH

S100B attenuates microglia activation in gliomas: Possible role of STAT3 pathway

(2010) Leying Zhang et al.   GLIA

The Calcium-binding Protein S100B Down-regulates p53 and Apoptosis in Malignant Melanoma

(2010) Jing Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A1: A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+Handling, Sarcomeric, and Mitochondrial Function

(2010) Mirko Völkers et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

In vitro aging of 3T3-L1 mouse adipocytes leads to altered metabolism and response to inflammation

(2009) Elena Zoico et al.   BIOGERONTOLOGY

S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm

(2009) Marion Hofmann Bowman et al.   CIRCULATION RESEARCH

Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein

(2009) Jörg Klingelhöfer et al.   FEBS Journal

TheQγcomponent of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1

(2009) Benjamin L. Prosser et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Calprotectin — A Novel Marker of Obesity

(2009) Ole Hartvig Mortensen et al.   PLoS One

S100B serum levels are closely correlated with body mass index: An important caveat in neuropsychiatric research

(2009) Johann Steiner et al.   PSYCHONEUROENDOCRINOLOGY

PRDM16: the interconvertible adipo-myocyte switch

(2009) Gema Frühbeck et al.   TRENDS IN CELL BIOLOGY

S100B's double life: Intracellular regulator and extracellular signal

(2008) Rosario Donato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain

(2008) Wei Xing Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance

(2008) Noriyuki Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum levels of S100B are decreased in chronic starvation and normalize with weight gain

(2008) Kristian Holtkamp et al.   JOURNAL OF NEURAL TRANSMISSION

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE