Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications

Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs

(2013) Eliezer Joseph Tassone et al.   CARDIOVASCULAR RESEARCH

Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function

(2013) Rodrigo A. Fraga-Silva et al.   HYPERTENSION

Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma: implications for inflammation and neovascularization

(2012) K-Raman Purushothaman et al.   CARDIOVASCULAR PATHOLOGY

Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction

(2012) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation

(2012) Jun Mori et al.   Circulation-Heart Failure

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

(2012) Chris Tikellis et al.   CLINICAL SCIENCE

Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

(2012) Y. P. R. Jarajapu et al.   DIABETES

Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats

(2012) Jennifer Lo et al.   EXPERIMENTAL PHYSIOLOGY

Chronic activation of endogenous angiotensin-converting enzyme 2 protects diabetic rats from cardiovascular autonomic dysfunction

(2012) Tatiane M. Murça et al.   EXPERIMENTAL PHYSIOLOGY

Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2–Null Mice

(2012) Vaibhav B. Patel et al.   HYPERTENSION

Angiotensin-Converting Enzyme-2 Overexpression Improves Left Ventricular Remodeling and Function in a Rat Model of Diabetic Cardiomyopathy

(2012) Bo Dong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ACE2, angiotensin-(1–7), and Mas: the other side of the coin

(2012) Michael Bader   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of Angiotensin-(1–7) effects on the cardiovascular system in an experimental model of Type-1 diabetes

(2012) Mariam H.M. Yousif et al.   PHARMACOLOGICAL RESEARCH

ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production

(2012) Hai-Yan Jin et al.   PLoS One

Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction

(2012) Tatiane M. Murça et al.   REGULATORY PEPTIDES

The Role of Oxidative Stress in the Pathogenesis of Diabetic Vascular Complications

(2012) Shuji Sasaki et al.   Diabetes & Metabolism Journal

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

(2011) Alia Shatanawi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway

(2011) Saghir Akhtar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit

(2011) Sreedhar Bodiga et al.   CARDIOVASCULAR RESEARCH

Role of ACE2 in diastolic and systolic heart failure

(2011) Wang Wang et al.   HEART FAILURE REVIEWS

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

(2011) Aino Soro-Paavonen et al.   JOURNAL OF HYPERTENSION

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model

(2011) Kumiko Taguchi et al.   PHARMACOLOGICAL RESEARCH

Angiotensin II Type 1 Receptor-Dependent Oxidative Stress Mediates Endothelial Dysfunction in Type 2 Diabetic Mice

(2010) Wing Tak Wong et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse

(2010) Merlin C. Thomas et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Angiotensin II–Induced Vascular Smooth Muscle Cell Migration and Growth Are Mediated by Cytochrome P450 1B1–Dependent Superoxide Generation

(2010) Fariborz A. Yaghini et al.   HYPERTENSION

Mast cell chymase limits the cardiac efficacy of Ang I–converting enzyme inhibitor therapy in rodents

(2010) Chih-Chang Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

(2009) Ratnadeep Basu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint

(2009) Elena MV de Cavanagh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction

(2009) Zamaneh Kassiri et al.   Circulation-Heart Failure

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

(2009) G. Y. Oudit et al.   DIABETES

Oxidative Stress, Diabetes, and Diabetic Complications

(2009) Wei Wei et al.   HEMOGLOBIN

Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes

(2009) Slava Epelman et al.   JOURNAL OF CARDIAC FAILURE

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats

(2009) May Al-Maghrebi et al.   PHARMACOLOGICAL RESEARCH

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis

(2008) Fina Lovren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis

(2008) Bo Dong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart

(2008) Chantal Mercure et al.   CIRCULATION RESEARCH

The angiotensin-(1–7) receptor agonist AVE0991 is cardioprotective in diabetic rats

(2008) Linda Ebermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications

(2008) Sho-ichi Yamagishi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Update on tissue renin–angiotensin systems

(2008) Michael Bader et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions

(2008) JC Sluimer et al.   JOURNAL OF PATHOLOGY

Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure

(2008) Slava Epelman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The sweeter side of ACE2: Physiological evidence for a role in diabetes

(2008) Sharell M. Bindom et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY