Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid β (1–42) peptide

(2020) Madhukar S. Said et al.   BIOPHYSICAL CHEMISTRY

Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening

(2019) Meijie Li et al.   Microbial Cell Factories

Redirecting Metabolic Flux via Combinatorial Multiplex CRISPRi-Mediated Repression for Isopentenol Production in Escherichia coli

(2019) Tian Tian et al.   ACS Synthetic Biology

Identifying and engineering the ideal microbial terpenoid production host

(2019) Sandra Moser et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhancing epi ‐cedrol production in Escherichia coli by fusion expression of farnesyl pyrophosphate synthase and epi ‐cedrol synthase

(2019) Govinda R. Navale et al.   ENGINEERING IN LIFE SCIENCES

Systematic Optimization of Limonene Production in Engineered Escherichia coli

(2019) Jihua Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulating the Precursor and Terpene Synthase Supply for the Whole-Cell Biocatalytic Production of the Sesquiterpene (+)-Zizaene in a Pathway Engineered E. coli

(2019) Francisco Aguilar et al.   Genes

Improved Production and In Situ Recovery of Sesquiterpene (+)-Zizaene from Metabolically-Engineered E. coli

(2019) Francisco Aguilar et al.   MOLECULES

Overexpression of the transcription factor HAC1 improves nerolidol production in engineered yeast

(2019) Zhenzhen Qu et al.   ENZYME AND MICROBIAL TECHNOLOGY

Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit

(2018) Taro Ozaki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overproduction of isoprenoids by Saccharomyces cerevisiae in a synthetic grape juice medium in the absence of plant genes

(2018) L. Camesasca et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae

(2018) Bingyin Peng et al.   METABOLIC ENGINEERING

De novo synthesis of the sedative valerenic acid in Saccharomyces cerevisiae

(2018) Jeff Wong et al.   METABOLIC ENGINEERING

Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis

(2018) Hailin Chen et al.   Microbial Cell Factories

Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site

(2018) Bastian Vögeli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Platform for Terpenoid Production: Escherichia coli and Yeast

(2018) Chonglong Wang et al.   Frontiers in Microbiology

Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine

(2018) Jigang Wang et al.   Engineering

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes

(2017) Sandip S Shinde et al.   JOURNAL OF ANTIBIOTICS

Metabolic engineering of Escherichia coli for production of valerenadiene

(2017) S. Eric Nybo et al.   JOURNAL OF BIOTECHNOLOGY

Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH

(2017) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene

(2017) Yating Hu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli

(2017) Lixia Yang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae

(2017) Bingyin Peng et al.   METABOLIC ENGINEERING

Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae

(2017) Jianzhi Zhao et al.   Microbial Cell Factories

Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production

(2017) Xiaonan Liu et al.   Microbial Cell Factories

Harnessing yeast organelles for metabolic engineering

(2017) Sarah K Hammer et al.   Nature Chemical Biology

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase

(2017) Vijaykumar Karuppiah et al.   ACS Catalysis

A New Era of Genome Integration—Simply Cut and Paste!

(2017) Zihe Liu et al.   ACS Synthetic Biology

In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production

(2017) Xixian Chen et al.   ACS Synthetic Biology

Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6

(2017) Guangkai Bian et al.   Biotechnology Journal

Combinatorial pathway optimization inEscherichia coliby directed co-evolution of rate-limiting enzymes and modular pathway engineering

(2016) Xiaomei Lv et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering Escherichia coli for high-yield geraniol production with biotransformation of geranyl acetate to geraniol under fed-batch culture

(2016) Wei Liu et al.   Biotechnology for Biofuels

Farnesol production inEscherichia colithrough the construction of a farnesol biosynthesis pathway - application of PgpB and YbjG phosphatases

(2016) Chonglong Wang et al.   Biotechnology Journal

A novel MVA-mediated pathway for isoprene production in engineered E. coli

(2016) Jianming Yang et al.   BMC BIOTECHNOLOGY

Oxidative Cyclization in Natural Product Biosynthesis

(2016) Man-Cheng Tang et al.   CHEMICAL REVIEWS

Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase inSaccharomyces cerevisiae

(2016) Yu Deng et al.   JOURNAL OF APPLIED MICROBIOLOGY

Mitochondrial acetyl-CoA utilization pathway for terpenoid productions

(2016) Jifeng Yuan et al.   METABOLIC ENGINEERING

A highly efficient single-step, markerless strategy for multi-copy chromosomal integration of large biochemical pathways in Saccharomyces cerevisiae

(2016) Shuobo Shi et al.   METABOLIC ENGINEERING

Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli

(2016) Chen Yang et al.   METABOLIC ENGINEERING

Isopentenyl diphosphate (IPP)-bypass mevalonate pathways for isopentenol production

(2016) Aram Kang et al.   METABOLIC ENGINEERING

Fermentative production and direct extraction of (−)-α-bisabolol in metabolically engineered Escherichia coli

(2016) Gui Hwan Han et al.   Microbial Cell Factories

Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts

(2016) Jung-Hun Kim et al.   Microbial Cell Factories

Combinatorial engineering of hybrid mevalonate pathways in Escherichia coli for protoilludene production

(2016) Liyang Yang et al.   Microbial Cell Factories

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis inEscherichia coli

(2016) Bradley Walters Biggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereoselective quenching of cedryl carbocation in epicedrol biosynthesis

(2016) Sandip S. Shinde et al.   TETRAHEDRON LETTERS

Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae

(2016) Xiaomei Lv et al.   Nature Communications

Affibody Scaffolds Improve Sesquiterpene Production in Saccharomyces cerevisiae

(2016) Stefan Tippmann et al.   ACS Synthetic Biology

Bacterial Production of Pinene by a Laboratory-Evolved Pinene-Synthase

(2016) Miki Tashiro et al.   ACS Synthetic Biology

High-throughput recombinant protein expression inEscherichia coli: current status and future perspectives

(2016) Baolei Jia et al.   Open Biology

Farnesol production inEscherichia colithrough the construction of a farnesol biosynthesis pathway - application of PgpB and YbjG phosphatases

(2016) Chonglong Wang et al.   Biotechnology Journal

Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production

(2015) Congqiang Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Building terpene production platforms in yeast

(2015) Xun Zhuang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Production of farnesene and santalene bySaccharomyces cerevisiaeusing fed-batch cultivations withRQ-controlled feed

(2015) Stefan Tippmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Production of natural products through metabolic engineering of Saccharomyces cerevisiae

(2015) Anastasia Krivoruchko et al.   CURRENT OPINION IN BIOTECHNOLOGY

Geranyl diphosphate synthase: An important regulation point in balancing a recombinant monoterpene pathway in Escherichia coli

(2015) Jia Zhou et al.   ENZYME AND MICROBIAL TECHNOLOGY

Microbial Synthesis of Myrcene by Metabolically Engineered Escherichia coli

(2015) Eun-Mi Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

Antibiofilm activity of tert-BuOH functionalized ionic liquids with methylsulfonate counteranions

(2015) Govinda R. Navale et al.   RSC Advances

Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli

(2015) Helen S. Toogood et al.   ACS Synthetic Biology

Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli

(2015) Kevin W. George et al.   Scientific Reports

Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis

(2014) Weixue Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancing Terpene Yield from Sugars via Novel Routes to 1-Deoxy-d-Xylulose 5-Phosphate

(2014) James Kirby et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A kinetic-based approach to understanding heterologous mevalonate pathway function inE. coli

(2014) Lane J. Weaver et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction inEscherichia coli

(2014) Fayin Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering the productivity of recombinantEscherichia colifor limonene formation from glycerol in minimal media

(2014) Christian Willrodt et al.   Biotechnology Journal

Enhanced isoprene biosynthesis in Saccharomyces cerevisiae by engineering of the native acetyl-CoA and mevalonic acid pathways with a push-pull-restrain strategy

(2014) Xiaomei Lv et al.   JOURNAL OF BIOTECHNOLOGY

Microbial production of sabinene—a new terpene-based precursor of advanced biofuel

(2014) Haibo Zhang et al.   Microbial Cell Factories

MEP pathway-mediated isopentenol production in metabolically engineered Escherichia coli

(2014) Huaiwei Liu et al.   Microbial Cell Factories

Methylerythritol 4-phosphate (MEP) pathway metabolic regulation

(2014) A. Banerjee et al.   NATURAL PRODUCT REPORTS

Metabolic engineering of volatile isoprenoids in plants and microbes

(2014) CLAUDIA E. VICKERS et al.   PLANT CELL AND ENVIRONMENT

Terpene synthases are widely distributed in bacteria

(2014) Yuuki Yamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Synthesis of Pinene

(2014) Stephen Sarria et al.   ACS Synthetic Biology

Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications

(2014) Bharat Singh et al.   3 Biotech

Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

(2013) Lishan Zhao et al.   Annual Review of Biochemistry

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly

(2013) Farnaz F. Nowroozi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Construction of a controllable β-carotene biosynthetic pathway by decentralized assembly strategy inSaccharomyces cerevisiae

(2013) Wenping Xie et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of Escherichia coli for high-specificity production of isoprenol and prenol as next generation of biofuels

(2013) Yanning Zheng et al.   Biotechnology for Biofuels

Metabolic engineering of Escherichia coli for the biosynthesis of alpha-pinene

(2013) Jianming Yang et al.   Biotechnology for Biofuels

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids inSaccharomyces cerevisiae

(2013) Stefan Tippmann et al.   Biotechnology Journal

Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase

(2013) Yan Zhou et al.   BIOTECHNOLOGY LETTERS

In situ product removal in fermentation systems: improved process performance and rational extractant selection

(2013) Julian T. Dafoe et al.   BIOTECHNOLOGY LETTERS

Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway

(2013) Aparajita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Escherichia coli for selective geraniol production with minimized endogenous dehydrogenation

(2013) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production

(2013) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories

(2013) Evamaria Gruchattka et al.   Microbial Cell Factories

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Engineering dynamic pathway regulation using stress-response promoters

(2013) Robert H Dahl et al.   NATURE BIOTECHNOLOGY

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

Post-translational events and modifications regulating plant enzymes involved in isoprenoid precursor biosynthesis

(2013) Andréa Hemmerlin   PLANT SCIENCE

Combination of Entner-Doudoroff Pathway with MEP Increases Isoprene Production in Engineered Escherichia coli

(2013) Huaiwei Liu et al.   PLoS One

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method

(2013) Ruiyang Zou et al.   PLoS One

Engineering Monoterpene Production in Yeast Using a Synthetic Dominant Negative Geranyl Diphosphate Synthase

(2013) Codruta Ignea et al.   ACS Synthetic Biology

Significantly enhanced production of isoprene by ordered coexpression of genes dxs, dxr, and idi in Escherichia coli

(2012) Xiaomei Lv et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Production of miltiradiene by metabolically engineeredSaccharomyces cerevisiae

(2012) Zhubo Dai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recombinant protein expression and purification: A comprehensive review of affinity tags and microbial applications

(2012) Carissa L. Young et al.   Biotechnology Journal

Integrated bioprocess for the stereospecific production of linalool oxides from linalool with Corynespora cassiicola DSM 62475

(2012) Sebastian Bormann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis

(2012) Atsushi Minami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

(2012) Yongjin J. Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carotenoid-based phenotypic screen of the yeast deletion collection reveals new genes with roles in isoprenoid production

(2012) Bilge Özaydın et al.   METABOLIC ENGINEERING

Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae

(2012) Gionata Scalcinati et al.   Microbial Cell Factories

Enhancing Production of Bio-Isoprene Using Hybrid MVA Pathway and Isoprene Synthase in E. coli

(2012) Jianming Yang et al.   PLoS One

Overexpressing 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGR) in the Lactococcal Mevalonate Pathway for Heterologous Plant Sesquiterpene Production

(2012) Adelene Ai-Lian Song et al.   PLoS One

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway

(2011) Yaru Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bio-isoprene production using exogenous MVA pathway and isoprene synthase in Escherichia coli

(2011) Jianming Yang et al.   BIORESOURCE TECHNOLOGY

Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases

(2011) Suzanne M. Ma et al.   METABOLIC ENGINEERING

Harnessing yeast subcellular compartments for the production of plant terpenoids

(2011) Moran Farhi et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for α-farnesene production

(2011) Chonglong Wang et al.   METABOLIC ENGINEERING

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Identification and microbial production of a terpene-based advanced biofuel

(2011) Pamela P. Peralta-Yahya et al.   Nature Communications

Diversion of Flux toward Sesquiterpene Production inSaccharomyces cerevisiaeby Fusion of Host and Heterologous Enzymes

(2010) Line Albertsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway

(2010) Chonglong Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases

(2010) Pamela J. Weathers et al.   PHYTOCHEMISTRY REVIEWS

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

(2010) E. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Improved Squalene Production via Modulation of the Methylerythritol 4-Phosphate Pathway and Heterologous Expression of Genes from Streptomyces peucetius ATCC 27952 in Escherichia coli

(2009) G. P. Ghimire et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

(2009) Mohammad A. Asadollahi et al.   METABOLIC ENGINEERING

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli

(2008) Hisashi Harada et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols

(2008) Chikara Ohto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced bioproduction of carvone in a two-liquid-phase partitioning bioreactor with a highly hydrophobic biocatalyst

(2008) Jenna L.E. Morrish et al.   BIOTECHNOLOGY AND BIOENGINEERING

Isolation and functional characterization of a β-eudesmol synthase, a new sesquiterpene synthase fromZingiber zerumbetSmith

(2008) Fengnian Yu et al.   FEBS LETTERS