Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4

(2016) Bradley Walters Biggs et al.   ACS Chemical Biology

Into new territory: improved microbial synthesis through engineering of the essential metabolic network

(2016) Michael D Lynch   CURRENT OPINION IN BIOTECHNOLOGY

Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products

(2016) Yong Fuga Li et al.   FUNGAL GENETICS AND BIOLOGY

Rewriting yeast central carbon metabolism for industrial isoprenoid production

(2016) Adam L. Meadows et al.   NATURE

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis inEscherichia coli

(2016) Bradley Walters Biggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate

(2016) Steven Edgar et al.   ACS Synthetic Biology

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

(2016) Andy M. Bailey et al.   Scientific Reports

Genome mining of astaxanthin biosynthetic genes fromSphingomonassp. ATCC 55669 for heterologous overproduction inEscherichia coli

(2015) Tian Ma et al.   Biotechnology Journal

Dynamic metabolic engineering: New strategies for developing responsive cell factories

(2015) Irene M. Brockman et al.   Biotechnology Journal

Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

(2015) Man-Cheng Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products inStreptomyces

(2015) Chaoxian Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted engineering and scale up of lycopene overproduction in Escherichia coli

(2015) Fayin Zhu et al.   PROCESS BIOCHEMISTRY

Genome mining of astaxanthin biosynthetic genes fromSphingomonassp. ATCC 55669 for heterologous overproduction inEscherichia coli

(2015) Tian Ma et al.   Biotechnology Journal

Dynamic metabolic engineering: New strategies for developing responsive cell factories

(2015) Irene M. Brockman et al.   Biotechnology Journal

In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction inEscherichia coli

(2014) Fayin Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites inAspergillus oryzae: Total Biosynthesis of Aflatrem

(2014) Koichi Tagami et al.   CHEMBIOCHEM

Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway

(2014) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cytochrome P450 Serves as an Unexpected Terpene Cyclase during Fungal Meroterpenoid Biosynthesis

(2013) Yit-Heng Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Recent Advances on Filamentous Fungal Biofilms for Industrial Uses

(2012) Marcel Gutiérrez-Correa et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Simple Cloning via Direct Transformation of PCR Product (DNA Multimer) to Escherichia coli and Bacillus subtilis

(2011) Chun You et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium–calcineurin signaling cascade in Aspergillus nidulans

(2011) Lina Gao et al.   CELLULAR SIGNALLING

Heterogenic expression of genes encoding secreted proteins at the periphery of Aspergillus niger colonies

(2010) Arman Vinck et al.   ENVIRONMENTAL MICROBIOLOGY

Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi

(2010) Min Jin Kwon et al.   MOLECULAR MICROBIOLOGY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Characteristic analysis of transformants in T-DNA mutation library of Monascus ruber

(2009) Yanchun Shao et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Genetic engineering of filamentous fungi — Progress, obstacles and future trends

(2008) Vera Meyer   BIOTECHNOLOGY ADVANCES

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING