Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

(2017) Chao Zhang et al.   Scientific Reports

Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis

(2017) Tzuhua Lin et al.   Stem Cell Research & Therapy

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

(2017) Géraldine Genard et al.   Frontiers in Immunology

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

Radiotherapy and the tumor microenvironment: The “macro” picture

(2017) Emma Louise Walton   Biomedical Journal

Macrophage biology plays a central role during ionizing radiation-elicited tumor response

(2017) Qiuji Wu et al.   Biomedical Journal

(-)-Epigallocatechin-3-Gallate Protects SH-SY5Y Cells Against 6-OHDA-Induced Cell Death through STAT3 Activation

(2017) Lili Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration

(2016) Edward J. Calabrese   BIOGERONTOLOGY

Discovering New Genes in the Pathways of Common Sporadic Neurodegenerative Diseases: A Bioinformatics Approach

(2016) Yong Hwan Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

Dose-dependent neuroprotective effect of caffeine on a rotenone-induced rat model of parkinsonism: A histological study

(2016) Amira M. Soliman et al.   NEUROSCIENCE LETTERS

Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Donepezil Regulates 1-Methyl-4-phenylpyridinium-Induced Microglial Polarization in Parkinson’s Disease

(2015) Teng Chen et al.   ACS Chemical Neuroscience

What is hormesis and its relevance to healthy aging and longevity?

(2015) Edward J. Calabrese et al.   BIOGERONTOLOGY

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics

(2015) Hao Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture

(2015) Khaled Radad et al.   FOLIA NEUROPATHOLOGICA

Historical foundations of hormesis

(2015) Edward J. Calabrese   Homeopathy

Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease

(2015) Paul B. Huleatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Frontiers in Selective Human MAO-B Inhibitors

(2015) Simone Carradori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway

(2015) Dong-Woo Kim et al.   LIFE SCIENCES

Extending Injury- and Disease-Resistant CNS Phenotypes by Repetitive Epigenetic Conditioning

(2015) Jeffrey M. Gidday   Frontiers in Neurology

Effectiveness of Traditional Chinese Medicine as an Adjunct Therapy for Parkinson’s Disease: A Systematic Review and Meta-Analysis

(2015) Guoxin Zhang et al.   PLoS One

Original article Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture

(2014) Khaled Radad et al.   FOLIA NEUROPATHOLOGICA

Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury

(2014) Kentaro Hayakawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Macrophage Mediates the Renoprotective Effects of Endotoxin Preconditioning

(2014) T. Hato et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluation of Lovastatin Effects on Expression of Anti-apoptotic Nrf2 and PGC-1α Genes in Neural Stem Cells Treated with Hydrogen Peroxide

(2014) Alireza Abdanipour et al.   MOLECULAR NEUROBIOLOGY

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

(2014) Augusta Pisanu et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Low-Dose Levodopa Protects Nerve Cells from Oxidative Stress and Up-Regulates Expression of pCREB and CD39

(2014) Shi-Ying Zhong et al.   PLoS One

Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease

(2014) Jesús Pérez-H et al.   TOXICOLOGY

Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner

(2013) Niva Segev-Amzaleg et al.   BRAIN BEHAVIOR AND IMMUNITY

Allicin protects rat cortical neurons against mechanical trauma injury by regulating nitric oxide synthase pathways

(2013) Yue-fei Zhou et al.   BRAIN RESEARCH BULLETIN

Hormetic mechanisms

(2013) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Biphasic dose responses in biology, toxicology and medicine: Accounting for their generalizability and quantitative features

(2013) Edward J. Calabrese   ENVIRONMENTAL POLLUTION

Modeling neurodegenerative diseases in Caenorhabditis elegans

(2013) Jia Li et al.   EXPERIMENTAL NEUROLOGY

Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity

(2013) KASTHURI BAI MAGALINGAM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroprotective mechanisms of the standardized extract of Bacopa monniera in a paraquat/diquat-mediated acute toxicity

(2013) Manjeet Singh et al.   NEUROCHEMISTRY INTERNATIONAL

Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease

(2013) Ru-Huei Fu et al.   NEUROPHARMACOLOGY

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways

(2013) M.P. Cunha et al.   NEUROSCIENCE

Protective Effects of Curcumin Against Rotenone and Salsolinol-Induced Toxicity: Implications for Parkinson’s Disease

(2013) Zakiya Qualls et al.   NEUROTOXICITY RESEARCH

Neuroprotective effect of EGb761® and low-dose whole-body γ-irradiation in a rat model of Parkinson’s disease

(2013) Mona A El-Ghazaly et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis

(2012) Jing-Hsien Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effects of Low Concentrations of Rotenone Upon Mitohormesis in SH-SY5Y Cells

(2012) Xiong Yuyun et al.   Dose-Response

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

(2012) Patricia K. Sonsalla et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells

(2012) De-Jian Guo et al.   PHARMACEUTICAL BIOLOGY

Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control

(2011) Roshan Cools et al.   BIOLOGICAL PSYCHIATRY

Toxicology rewrites its history and rethinks its future: Giving equal focus to both harmful and beneficial effects

(2011) Edward J. Calabrese   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The role of oxidative stress in neuromelanin synthesis in PC12 cells

(2011) A.-Y. He et al.   NEUROSCIENCE

Low Concentrations of Methamphetamine Can Protect Dopaminergic Cells against a Larger Oxidative Stress Injury: Mechanistic Study

(2011) Amina El Ayadi et al.   PLoS One

The hormesis database: The occurrence of hormetic dose responses in the toxicological literature

(2011) Edward J. Calabrese et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hormesis provides a generalized quantitative estimate of biological plasticity

(2011) Edward J. Calabrese et al.   Journal of Cell Communication and Signaling

Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models

(2010) Hyo Geun Kim et al.   BRITISH JOURNAL OF NUTRITION

Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway

(2010) Chi Xin Tiong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hormesis in high-throughput screening of antibacterial compounds in E coli

(2010) Edward J Calabrese et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo

(2010) Ah-Reum Doo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models

(2010) Jin Gyu Choi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective Effect of Cyperi Rhizoma Against 6-Hydroxydopamine-Induced Neuronal Damage

(2010) Chang-Hoon Lee et al.   JOURNAL OF MEDICINAL FOOD

Cellular Stress Responses, Mitostress and Carnitine Insufficiencies as Critical Determinants in Aging and Neurodegenerative Disorders: Role of Hormesis and Vitagenes

(2010) Vittorio Calabrese et al.   NEUROCHEMICAL RESEARCH

Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity

(2010) Hirokazu Hara et al.   NEUROCHEMISTRY INTERNATIONAL

Dose effect of tumor necrosis factor-α on in vitro osteogenic differentiation of mesenchymal stem cells on biodegradable polymeric microfiber scaffolds

(2009) Paschalia M. Mountziaris et al.   BIOMATERIALS

Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease

(2009) Ah-Reum Doo et al.   NEUROLOGICAL RESEARCH

Additive Protective Effects of Donepezil and Nicotine Against Salsolinol-Induced Cytotoxicity in SH-SY5Y Cells

(2009) Jharna R. Das et al.   NEUROTOXICITY RESEARCH

Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model

(2009) Simon Young et al.   TISSUE ENGINEERING PART A

Dose-Response Features of Neuroprotective Agents: An Integrative Summary

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Enhancing and Regulating Neurite Outgrowth

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Neuroscience and Hormesis: Overview and General Findings

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Pharmacological Enhancement of Neuronal Survival

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Hormesis Predicts Low-Dose Responses Better Than Threshold Models

(2008) Edward J. Calabrese et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty

(2008) R. Varadhan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Apomorphine offers new insight into dopaminergic neuron vulnerability in mesencephalic cultures

(2008) Francesca Vaglini et al.   NEUROPHARMACOLOGY

Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons

(2008) B. Galan-Rodriguez et al.   NEUROPHARMACOLOGY

Thymoquinone protects dopaminergic neurons against MPP+and rotenone

(2008) Khaled Radad et al.   PHYTOTHERAPY RESEARCH

Neuronal effects of 4-t-Butylcatechol: A model for catechol-containing antioxidants

(2008) Y LO et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

9-Methyl-β-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture

(2007) Juliane Hamann et al.   NEUROCHEMISTRY INTERNATIONAL