Neural stem cell therapy for subacute and chronic ischemic stroke

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

B cells do not have a major pathophysiologic role in acute ischemic stroke in mice

(2017) Michael K. Schuhmann et al.   Journal of Neuroinflammation

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

(2017) Ruimin Ge et al.   Journal of Neuroinflammation

Clinical trial design for stem cell therapies in stroke: What have we learned?

(2017) Keith W. Muir   NEUROCHEMISTRY INTERNATIONAL

Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis

(2017) Luanne M. Metz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transplantation of iPS cell-derived neural progenitors overexpressing SDF-1α increases regeneration and functional recovery after ischemic stroke

(2017) Monica Chau et al.   Oncotarget

Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice

(2017) Tingting Zhang et al.   Stem Cell Research & Therapy

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

(2017) Andrea Becerra-Calixto et al.   Frontiers in Molecular Neuroscience

Inflammatory Disequilibrium in Stroke

(2016) Danica Petrovic-Djergovic et al.   CIRCULATION RESEARCH

New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain

(2016) Poornima Venkat et al.   CROATIAN MEDICAL JOURNAL

Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes

(2016) M. Bacigaluppi et al.   JOURNAL OF NEUROSCIENCE

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study

(2016) Dheeraj Kalladka et al.   LANCET

Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain

(2016) Byung-Woo Yoon et al.   Neural Regeneration Research

Microglia and Monocyte-Derived Macrophages in Stroke

(2016) Eunhee Kim et al.   Neurotherapeutics

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke

(2016) Gary K. Steinberg et al.   STROKE

Long-Term Effects of Magnetically Targeted Ferumoxide-Labeled Human Neural Stem Cells in Focal Cerebral Ischemia

(2015) Miyeoun Song et al.   CELL TRANSPLANTATION

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway

(2015) F. Yang et al.   NEUROSCIENCE

The blood–brain barrier—Gatekeeper to neuronal homeostasis: Clinical implications in the setting of stroke

(2015) Karl Schoknecht et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice

(2015) Josephine Herz et al.   STROKE

Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke

(2015) Auston Eckert et al.   Stem Cells Translational Medicine

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

The Effect of Stromal Cell-Derived Factor 1 in the Migration of Neural Stem Cells

(2014) Liping Xue et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

(2014) Lijie Huang et al.   International Journal of Medical Sciences

Neural Stem Cell Protects Aged Rat Brain from Ischemia–Reperfusion Injury through Neurogenesis and Angiogenesis

(2014) Yaohui Tang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia

(2014) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Injury-Induced Neurogenesis

(2014) Tzong-Shiue Yu et al.   NEUROSCIENTIST

iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats

(2014) Monica J. Chau et al.   STEM CELLS

Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury

(2014) Lei Huang et al.   Stem Cell Research & Therapy

Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons

(2013) Stefano Pluchino et al.   BRAIN

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

In Vivo and in Vitro Characterization of the Angiogenic Effect of CTX0E03 Human Neural Stem Cells

(2013) Caroline Hicks et al.   CELL TRANSPLANTATION

Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke

(2013) Da-Jeong Chang et al.   CELL TRANSPLANTATION

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

(2013) Eric J. Benner et al.   NATURE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Vector-Free and Transgene-Free Human iPS Cells Differentiate into Functional Neurons and Enhance Functional Recovery after Ischemic Stroke in Mice

(2013) Osama Mohamad et al.   PLoS One

Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice

(2013) Danielle Drury-Stewart et al.   Stem Cell Research & Therapy

Induced pluripotent stem cell-derived neural stem cells: new hope for stroke?

(2013) Jia Liu   Stem Cell Research & Therapy

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice

(2012) Hiroyuki Sakata et al.   BRAIN

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

Neural stem cell transplantation in central nervous system disorders

(2012) Donatella De Feo et al.   CURRENT OPINION IN NEUROLOGY

The potential of stem cell therapy for stroke: is PISCES the sign?

(2012) Helen K. Smith et al.   FASEB JOURNAL

Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia

(2012) JIANPING WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone

(2012) B. Lacar et al.   JOURNAL OF NEUROSCIENCE

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

(2012) Ravid Shechter et al.   JOURNAL OF PATHOLOGY

Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats

(2012) Yutaka Mine et al.   NEUROBIOLOGY OF DISEASE

Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice

(2012) Seong Su Kang et al.   NEUROBIOLOGY OF DISEASE

The Age of Olfactory Bulb Neurons in Humans

(2012) Olaf Bergmann et al.   NEURON

Human Neural Progenitor Cell Engraftment Increases Neurogenesis and Microglial Recruitment in the Brain of Rats with Stroke

(2012) Zahra Hassani et al.   PLoS One

Human-Induced Pluripotent Stem Cells form Functional Neurons and Improve Recovery After Grafting in Stroke-Damaged Brain

(2012) Koichi Oki et al.   STEM CELLS

Intravenous injection of neural progenitor cells facilitates angiogenesis after cerebral ischemia

(2012) Yoshiyuki Moriyama et al.   Brain and Behavior

Cerebrovascular Complications of Diabetes: Focus on Stroke

(2012) Adviye Ergul et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

(2011) Robert H. Andres et al.   BRAIN

Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke

(2011) Feng-nan Niu et al.   BRAIN BEHAVIOR AND IMMUNITY

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury

(2011) Yong Gu et al.   JOURNAL OF NEUROCHEMISTRY

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice

(2011) Shalmali Patkar et al.   Stem Cell Research

Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair

(2011) Nobutaka Horie et al.   STEM CELLS

Implantation Site and Lesion Topology Determine Efficacy of a Human Neural Stem Cell Line in a Rat Model of Chronic Stroke

(2011) Edward J. Smith et al.   STEM CELLS

Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

(2011) Takayuki Nakagomi et al.   STEM CELLS AND DEVELOPMENT

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

A Neurovascular Perspective for Long-Term Changes After Brain Trauma

(2011) V. Pop et al.   Translational Stroke Research

Delayed transplantation of human neural precursor cells improves outcome from focal cerebral ischemia in aged rats

(2010) Kunlin Jin et al.   AGING CELL

Effect of human neural precursor cell transplantation on endogenous neurogenesis after focal cerebral ischemia in the rat

(2010) Kunlin Jin et al.   BRAIN RESEARCH

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Lab-Specific Gene Expression Signatures in Pluripotent Stem Cells

(2010) Aaron M. Newman et al.   Cell Stem Cell

Vascular Protection and Restorative Therapy in Ischemic Stroke

(2010) Toru Yamashita et al.   CELL TRANSPLANTATION

Intra-Arterial Injection of Neural Stem Cells using a Microneedle Technique does not Cause Microembolic Strokes

(2010) Joshua Y Chua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell Number and Timing of Transplantation Determine Survival of Human Neural Stem Cell Grafts in Stroke-Damaged Rat Brain

(2010) Vladimer Darsalia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tridermal Tumorigenesis of Induced Pluripotent Stem Cells Transplanted in Ischemic Brain

(2010) Hiromi Kawai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia

(2010) Kudret Tureyen et al.   JOURNAL OF NEUROCHEMISTRY

Tickets to the brain: Role of CCR2 and CX3CR1 in myeloid cell entry in the CNS

(2010) Marco Prinz et al.   JOURNAL OF NEUROIMMUNOLOGY

Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model

(2010) Hong J. Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of an Antimicrobial Agent on Atherosclerotic Plaques

(2010) Satoru Ohshima et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Proliferation in the human ipsilateral subventricular zone after ischemic stroke

(2010) J. Marti-Fabregas et al.   NEUROLOGY

The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties

(2010) Natividad Garrido-Mesa et al.   PHARMACOLOGICAL RESEARCH

Murine Neural Stem/Progenitor Cells Protect Neurons against Ischemia by HIF-1α–Regulated VEGF Signaling

(2010) Kate M. Harms et al.   PLoS One

Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis

(2010) K. S. Carbajal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potential of neural stem cells to repair stroke-induced brain damage

(2009) Yi Ping Liu et al.   ACTA NEUROPATHOLOGICA

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

(2009) Marco Bacigaluppi et al.   BRAIN

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

(2009) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

(2009) Mark H. Chin et al.   Cell Stem Cell

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

(2009) Kavon Rezai-Zadeh et al.   Journal of Neuroimmune Pharmacology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

VEGF enhance cortical newborn neurons and their neurite development in adult rat brain after cerebral ischemia

(2009) Yong-Quan Wang et al.   NEUROCHEMISTRY INTERNATIONAL

The relationship between SDF-1α/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats

(2009) Tatsuki Itoh et al.   NEUROLOGICAL RESEARCH

Leukocyte Recruitment and Ischemic Brain Injury

(2009) Gokhan Yilmaz et al.   NEUROMOLECULAR MEDICINE

MRI tracking of intravenously transplanted human neural stem cells in rat focal ischemia model

(2009) Miyeoun Song et al.   NEUROSCIENCE RESEARCH

Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy

(2009) Marcel M Daadi et al.   Regenerative Medicine

Neural Stem Cell Transplantation Benefits a Monogenic Neurometabolic Disorder During the Symptomatic Phase of Disease

(2009) Mylvaganam Jeyakumar et al.   STEM CELLS

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

(2009) Adviye Ergul et al.   VASCULAR PHARMACOLOGY

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Dynamic Changes in Vascular Permeability, Cerebral Blood Volume, Vascular Density, and Size after Transient Focal Cerebral Ischemia in Rats: Evaluation with Contrast-Enhanced Magnetic Resonance Imaging

(2008) Chien-Yuan Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain‐derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood‐derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt‐dependent signaling pathways

(2008) Jung Yeon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Generation of human-induced pluripotent stem cells

(2008) In-Hyun Park et al.   Nature Protocols

Regulation of cerebral vasculature in normal and ischemic brain

(2008) Tobias Kulik et al.   NEUROPHARMACOLOGY

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Adherent Self-Renewable Human Embryonic Stem Cell-Derived Neural Stem Cell Line: Functional Engraftment in Experimental Stroke Model

(2008) Marcel M. Daadi et al.   PLoS One

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT

Intracarotid Injection of Fluorescence Activated Cell-Sorted CD49d-Positive Neural Stem Cells Improves Targeted Cell Delivery and Behavior After Stroke in a Mouse Stroke Model

(2008) Raphael Guzman et al.   STROKE

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

(2008) Elaine Besancon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES