Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

(2017) Evan M. Cale et al.   IMMUNITY

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α 4 β 7

(2017) David Plotnik et al.   JOURNAL OF VIROLOGY

Mechanotransduction at the cell-matrix interface

(2017) K.A. Jansen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin

(2017) Subhash Chand et al.   VIROLOGY

Peptide Targeted by Human Antibodies Associated with HIV Vaccine-Associated Protection Assumes a Dynamic α-Helical Structure

(2017) Mohammed S. Aiyegbo et al.   PLoS One

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

(2016) Monica Vaccari et al.   NATURE MEDICINE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

(2016) Rosemarie D. Mason et al.   PLoS Pathogens

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

(2016) Géraldine Arrode-Brusés et al.   PLoS Pathogens

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

(2015) Amy W. Chung et al.   CELL

Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium

(2015) Ross M. Kedl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel

(2015) Ruimin Pan et al.   JOURNAL OF VIROLOGY

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

(2015) Jason Gorman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

(2015) Simone I Richardson et al.   Retrovirology

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

(2015) Jason Gorman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor

(2015) Kristina K. Peachman et al.   PLoS One

Sequence-Conserved and Antibody-Accessible Sites in the V1V2 Domain of HIV-1 gp120 Envelope Protein

(2014) Evgeny Shmelkov et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Impact of Asymptomatic Herpes Simplex Virus Type 2 Infection on Mucosal Homing and Immune Cell Subsets in the Blood and Female Genital Tract

(2014) B. Shannon et al.   JOURNAL OF IMMUNOLOGY

Envelope Glycoprotein Binding to the Integrin  4 7 Is Not a General Property of Most HIV-1 Strains

(2014) L. G. Perez et al.   JOURNAL OF VIROLOGY

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

(2014) Siddappa N Byrareddy et al.   NATURE MEDICINE

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

(2014) Susan Zolla-Pazner et al.   PLoS One

Cryptic Determinant of α4β7 Binding in the V2 Loop of HIV-1 gp120

(2014) Boonrat Tassaneetrithep et al.   PLoS One

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

HSV-2-Driven Increase in the Expression of α4β7 Correlates with Increased Susceptibility to Vaginal SHIVSF162P3 Infection

(2014) Diana Goode et al.   PLoS Pathogens

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

The Frequency of α4β7high Memory CD4+ T Cells Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection

(2013) Elena Martinelli et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Nanoparticle-based flow virometry for the analysis of individual virions

(2013) Anush Arakelyan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Rabbit Monoclonal Antibody Platform To Dissect the Diverse Repertoire of Antibody Epitopes for HIV-1 Env Immunogen Design

(2013) Y. Chen et al.   JOURNAL OF VIROLOGY

Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial

(2013) Susan Zolla-Pazner et al.   PLoS One

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Follicular dendritic cells: origin, phenotype, and function in health and disease

(2013) Adriano Aguzzi et al.   TRENDS IN IMMUNOLOGY

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144

(2012) Merlin L Robb et al.   LANCET INFECTIOUS DISEASES

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

(2012) Morgane Rolland et al.   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding

(2012) Gerald R. Nakamura et al.   PLoS One

Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7

(2012) Nicholas F. Parrish et al.   PLoS Pathogens

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

The CC′ and DE Loops in Ig Domains 1 and 2 of MAdCAM-1 Play Different Roles in MAdCAM-1 Binding to Low- and High-affinity Integrin α4β7

(2011) Hao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission

(2011) Fatima Nawaz et al.   PLoS Pathogens

A highly sensitive and dynamic immunofluorescent cytometric bead assay for the detection of HIV-1 p24

(2009) Angélique Biancotto et al.   JOURNAL OF VIROLOGICAL METHODS

Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection

(2009) X Wang et al.   Mucosal Immunology

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

(2009) M Kader et al.   Mucosal Immunology

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

The integrin  4 7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

(2009) C. Cicala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

The mucosal barrier and immune activation in HIV pathogenesis

(2008) Jason M Brenchley et al.   Current Opinion in HIV and AIDS

Role of the gastrointestinal tract in establishing infection in primates and humans

(2008) Saurabh Mehandru et al.   Current Opinion in HIV and AIDS