A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

(2018) Chao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

(2018) Lingshu Wang et al.   JOURNAL OF VIROLOGY

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

(2018) Kazuya Shirato et al.   VIROLOGY

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

(2018) Chao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution

(2018) Lei Yan et al.   Acta Crystallographica Section D-Structural Biology

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses

(2017) Justyna Ciejka et al.   Materials Science & Engineering C-Materials for Biological Applications

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

(2017) Yufeng Yu et al.   Nature Communications

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

(2017) James T. Earnest et al.   PLoS Pathogens

Identification and evolutionary dynamics of two novel human coronavirus OC43 genotypes associated with acute respiratory infections: phylogenetic, spatiotemporal and transmission network analyses

(2017) Xiang Yong Oong et al.   Emerging Microbes & Infections

Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN-alpha in a patient with newly diagnosed ALL

(2016) Karin Mayer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

(2016) Wanbo Tai et al.   JOURNAL OF VIROLOGY

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

(2016) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Human Coronavirus OC43 Associated with Fatal Encephalitis

(2016) Sofia Morfopoulou et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Molecular epidemiology and evolutionary histories of human coronavirus OC43 and HKU1 among patients with upper respiratory tract infections in Kuala Lumpur, Malaysia

(2016) Maryam Nabiel Al-Khannaq et al.   Virology Journal

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

(2015) Rudragouda Channappanavar et al.   JOURNAL OF INFECTIOUS DISEASES

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

(2015) Yang Yang et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Blocking of Exchange Proteins Directly Activated by cAMP Leads to Reduced Replication of Middle East Respiratory Syndrome Coronavirus

(2014) X. Tao et al.   JOURNAL OF VIROLOGY

Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness

(2014) J. Sui et al.   JOURNAL OF VIROLOGY

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

(2014) Fang Li   JOURNAL OF VIROLOGY

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

(2014) Tianlei Ying et al.   JOURNAL OF VIROLOGY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Influence of hydrophobic and electrostatic residues on SARS-coronavirus S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design

(2014) Halil Aydin et al.   PROTEIN SCIENCE

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

(2014) Shuai Xia et al.   VIRUS RESEARCH

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

Novel Treatment with Neuroprotective and Antiviral Properties against a Neuroinvasive Human Respiratory Virus

(2013) E. Brison et al.   JOURNAL OF VIROLOGY

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

(2013) X. Tao et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Severity and Outcome Associated With Human Coronavirus OC43 Infections Among Children

(2013) Andréanne Jean et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

(2012) Shibo Jiang et al.   Emerging Microbes & Infections

Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5

(2012) Patrick CY Woo et al.   Emerging Microbes & Infections

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a Novel Genotype due to Natural Recombination

(2011) S. K. P. Lau et al.   JOURNAL OF VIROLOGY

MR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model

(2011) Mingqian Tan et al.   PHARMACEUTICAL RESEARCH

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease

(2009) Geoffrey J. Gorse et al.   JOURNAL OF INFECTIOUS DISEASES

Type II transmembrane serine proteases in cancer and viral infections

(2009) So-Young Choi et al.   TRENDS IN MOLECULAR MEDICINE

A catalytically and genetically optimized β-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

(2009) Mike C Wolf et al.   Virology Journal