Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium

Plasmin-Mediated Activation of Pandemic H1N1 Influenza Virus Hemagglutinin Is Independent of the Viral Neuraminidase

(2013) L. V. Tse et al.   JOURNAL OF VIROLOGY

Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza

(2012) Mark L. Metersky et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

(2012) Joanna Baron et al.   JOURNAL OF VIROLOGY

Exposure to Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing to Increased Influenza A Infection

(2012) Matthew J. Kesic et al.   PLoS One

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype

(2012) J. Veits et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

(2012) Eva Böttcher-Friebertshäuser et al.   VACCINE

Aprotinin and similar protease inhibitors as drugs against influenza

(2011) O.P. Zhirnov et al.   ANTIVIRAL RESEARCH

Preventing and treating secondary bacterial infections with antiviral agents

(2011) Jonathan A McCullers   ANTIVIRAL THERAPY

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT

(2011) Frank Sielaff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets

(2011) E. J. A. Schrauwen et al.   JOURNAL OF GENERAL VIROLOGY

H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken

(2011) S. Gohrbandt et al.   JOURNAL OF GENERAL VIROLOGY

Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HAT

(2011) Katiuchia Uzzun Sales et al.   PLoS One

H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

(2011) Kosuke Soda et al.   Virology Journal

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

(2010) S. Bertram et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Modifications to the Hemagglutinin Cleavage Site Control the Virulence of a Neurotropic H1N1 Influenza Virus

(2010) X. Sun et al.   JOURNAL OF VIROLOGY

Contribution of Vaccine-Induced Immunity toward either the HA or the NA Component of Influenza Viruses Limits Secondary Bacterial Complications

(2010) V. C. Huber et al.   JOURNAL OF VIROLOGY

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Novel Type II Transmembrane Serine Proteases, MSPL and TMPRSS13, Proteolytically Activate Membrane Fusion Activity of the Hemagglutinin of Highly Pathogenic Avian Influenza Viruses and Induce Their Multicycle Replication

(2010) Y. Okumura et al.   JOURNAL OF VIROLOGY

ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice

(2009) Scott A. Tomlins et al.   EUROPEAN UROLOGY

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

(2009) Gero L. Becker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acquisition of a Polybasic Hemagglutinin Cleavage Site by a Low-Pathogenic Avian Influenza Virus Is Not Sufficient for Immediate Transformation into a Highly Pathogenic Strain

(2009) O. Stech et al.   JOURNAL OF VIROLOGY

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

Proteolytic bacteria in the lower digestive tract of poultry may affect avian influenza virus pathogenicity

(2009) M. D. King et al.   POULTRY SCIENCE

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

The activation and physiological functions of the proprotein convertases

(2008) N SEIDAH et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma

(2008) JM Lucas et al.   JOURNAL OF PATHOLOGY

Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

(2008) Y. Shirogane et al.   JOURNAL OF VIROLOGY

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY