DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway

(2020) Meihuan Zhao et al.   Frontiers in Pharmacology

Chlorogenic Acid Relieved Oxidative Stress Injury in Retinal Ganglion Cells Through IncRNA-TUG1/Nrf2

(2019) Weifeng Gong et al.   CELL CYCLE

Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation

(2019) Min Li et al.   Frontiers in Pharmacology

Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion

(2019) Jacopo Agrimi et al.   EBioMedicine

DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice

(2019) Ming Gao et al.   NEUROLOGICAL RESEARCH

Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis

(2019) Fangfang Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes

(2018) Ying Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling

(2018) Yunbo Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat

(2018) Neha Singh et al.   EPILEPSY RESEARCH

GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons

(2018) Ting Chien et al.   MOLECULAR PSYCHIATRY

DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats

(2018) Qianqian Qi et al.   NEUROSCIENCE LETTERS

Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells

(2018) Snehal Gite et al.   NUTRITIONAL NEUROSCIENCE

Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy

(2018) Xiaowen Ye et al.   Frontiers in Pharmacology

L-3-n-butylphthalide Reduces Tau Phosphorylation and Improves Cognitive Deficits in AβPP/PS1-Alzheimer's Transgenic Mice

(2018) Ying Peng et al.   JOURNAL OF ALZHEIMERS DISEASE

Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies

(2018) Cristina Carvalho et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

l-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia–Reperfusion Injury

(2017) Jing Xu et al.   NEUROCHEMICAL RESEARCH

Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway

(2017) Yan Zhang et al.   REJUVENATION RESEARCH

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial

(2016) Jianping Jia et al.   Alzheimers & Dementia

Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model

(2016) Chun-Yan Wang et al.   NEUROBIOLOGY OF AGING

A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives

(2016) Idriss Ali Abdoulaye et al.   Biomed Research International

L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats

(2015) Li-Chao Yang et al.   CNS Neuroscience & Therapeutics

Relationship between dietary pattern and cognitive function in elderly patients with type 2 diabetes mellitus

(2015) Mari Enomoto et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression

(2015) Thiruchelvam Kariharan et al.   NEUROBIOLOGY OF AGING

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

(2015) Ying Xu et al.   NEUROBIOLOGY OF AGING

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

(2015) L Li et al.   Cell Death & Disease

The Effect of Butylphthalide on the Brain Edema, Blood–Brain Barrier of Rats After Focal Cerebral Infarction and the Expression of Rho A

(2014) Jinyang Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

ZiBuPiYin Recipe Protects db/db Mice from Diabetes-Associated Cognitive Decline through Improving Multiple Pathological Changes

(2014) Jing Chen et al.   PLoS One

dl-3-n-Butylphthalide protects rat bone marrow stem cells against hydrogen peroxide-induced cell death through antioxidation and activation of PI3K-Akt pathway

(2012) Bo Sun et al.   NEUROSCIENCE LETTERS

Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway

(2012) Li Meng et al.   Small

bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways

(2012) Zhouguang Wang et al.   TOXICOLOGY LETTERS

Intensive multifactorial treatment and cognitive functioning in screen-detected type 2 diabetes — The ADDITION-Netherlands study: A cluster-randomized trial

(2011) Paula S. Koekkoek et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease

(2011) Nian Xiong et al.   NEUROBIOLOGY OF AGING

Ghrelin Modulates Insulin Sensitivity and Tau Phosphorylation in High Glucose-Induced Hippocampal Neurons

(2010) Ying Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

dl-3-n-Butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway

(2010) Jimei Li et al.   BRAIN RESEARCH

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin

(2009) L Danielyan et al.   CELL DEATH AND DIFFERENTIATION

Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and Diabetes Mellitus type-2

(2009) Massimiliano Plastino et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects

(2009) Ge Li et al.   PLoS One

Cognitive impairment correlates to low auditory event-related potential amplitudes in type 1 diabetes

(2008) Gerald K. Cooray et al.   PSYCHONEUROENDOCRINOLOGY