Review
Polymer Science
Cheirmadurai Kalirajan, Amey Dukle, Arputharaj Joseph Nathanael, Tae-Hwan Oh, Geetha Manivasagam
Summary: This review summarizes recent advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties. It also discusses novel approaches for developing various forms of polymeric biomaterials and highlights their applications in soft and hard tissue engineering. It underlines the future directions of polymeric biomaterials for successful clinical implications.
Review
Chemistry, Multidisciplinary
Zhuohao Zhang, Xinyuan Yang, Yuanjin Zhao, Fangfu Ye, Luoran Shang
Summary: Liquid crystal is a state of matter between solid and liquid, exhibiting orientational order and fluidity. In recent years, liquid crystal materials have been applied in the biomedical field due to their biocompatibility, multifunctionality, and responsiveness. This review summarizes the latest achievements and applications of liquid crystal materials in biomedicine, including drug delivery, bioimaging, tissue engineering, implantable devices, biosensing, and wearable devices, with the aim of stimulating innovative ideas for future liquid crystal-based advancements in drug development, artificial implants, disease diagnosis, and health monitoring.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Guillermo Blanco-Fernandez, Barbara Blanco-Fernandez, Anxo Fernandez-Ferreiro, Francisco J. Otero-Espinar
Summary: Liquid crystals possess unique physicochemical properties that make them applicable in various fields. This article provides an overview of the current landscape of lipidic liquid crystals in biomedical applications, with a focus on drug delivery, tissue engineering, and molecular imaging. The limitations and future prospects of lipidic liquid crystals in these applications are also discussed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Guanyu Mu, Yu Qiao, Mingyang Sui, Kenneth T. V. Grattan, Huijuan Dong, Jie Zhao
Summary: This article reviews the applications of acoustic manipulation techniques in the field of biomedical research, including cell manipulation, targeted drug release, and genetic disease diagnosis. Acoustic systems enable high precision positioning and faster transportation speeds, making them suitable for various biomedical tasks.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Anesthesiology
Spencer P. Walsh, David Shaz, David Amar
Summary: Recent evidence indicates that there is no significant difference in outcomes between thoracic surgery patients who are ventilated with low or higher tidal volume. The effects of low versus higher positive end-expiratory pressure are also unclear.
Article
Materials Science, Multidisciplinary
Raghav Garg, Flavia Vitale
Summary: The unique physical and chemical properties of MXenes have led to an increasing number of applications in biomedicine and healthcare. The expanding library of MXenes with customizable properties is enabling high-performance, application-specific MXene-based sensing and therapeutic platforms. This article highlights the emerging biomedical applications of MXenes, focusing on bioelectronics, biosensors, tissue engineering, and therapeutics. Examples of MXenes and their composites are presented, showcasing novel technological platforms and therapeutic strategies, and potential avenues for further developments are discussed. Finally, the materials, manufacturing, and regulatory challenges for the clinical translation of MXene-based biomedical technologies are addressed.
Article
Cardiac & Cardiovascular Systems
Peter C. Laussen
Summary: The recent events of the 2019 Coronavirus Disease pandemic have highlighted the importance of global medical collaboration and sharing of knowledge. The Invited Expert Opinion article by Peter C. Laussen emphasizes the significance of collaboration in Critical Care Medicine, particularly in the field of Pediatric Cardiac Critical Care.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Tung Thanh Pham, Phuong Le Tran, Cao Dai Phung, Hanh Thuy Nguyen, Canh Hung Nguyen, Chul Soon Yong, Jong Oh Kim, Simmyung Yook, Jee-Heon Jeong
Summary: The STIG method allows for universal coating of biomedical devices with different scales, shapes, and components, achieving precise, complete, and individual cell encapsulation. The thickness of the hydrogel layers can be easily controlled by adjusting the gelation time and ion release rate. This low-cost and easy-to-implement method has the potential to bring significant advances in various fields.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Emergency Medicine
Michael E. Winters, Kami Hu, Joseph P. Martinez, Haney Mallemat, William J. Brady
Summary: This review article summarizes important studies published in 2020 regarding resuscitation and care of select critically ill patients, highlighting key findings such as the use of dexamethasone for COVID-19 patients, lower levels of positive end-expiratory pressure for patients without acute respiratory distress syndrome, and early initiation of extracorporeal membrane oxygenation for out-of-hospital cardiac arrest patients with refractory ventricular fibrillation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Meng Yuan, Mehraneh Kermanian, Tarun Agarwal, Zhuang Yang, Satar Yousefiasl, Ziyong Cheng, Pingan Ma, Jun Lin, Aziz Maleki
Summary: With the development of nanochemistry research, nanomaterials have been increasingly used in vivo for disease-specific therapy. Defect-engineered nanoparticles have gained attention due to their excellent properties and ability to be easily adjusted. This tutorial review focuses on biomedical defect engineering, discussing defect classification, introduction strategies, and characterization techniques. Disease treatment strategies based on defective engineered nanomaterials are summarized, providing researchers with a simple and effective methodology to improve therapeutic effects.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Meng Yuan, Mehraneh Kermanian, Tarun Agarwal, Zhuang Yang, Satar Yousefiasl, Ziyong Cheng, Ping'an Ma, Jun Lin, Aziz Maleki
Summary: With the advancement of nanochemistry research, defective engineered nanomaterials have gained attention in biomedical applications. This tutorial review discusses the classification, introduction strategies, and characterization techniques of defective engineered nanomaterials, as well as the relationship between defects and properties. Additionally, disease treatment strategies based on defective engineered nanomaterials are summarized, providing a simple yet effective methodology for designing and improving the therapeutic effects of nanomaterial-based therapeutic platforms from a materials science perspective.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Le Minh Bui, Huong Thi Thu Phung, Thuy-Tien Ho Thi, Vijai Singh, Rupesh Maurya, Khushal Khambhati, Chia-Ching Wu, Md Jamal Uddin, Do Minh Trung, Dinh Toi Chu
Summary: The COVID-19 pandemic has accelerated advancements in biomedical engineering, improving diagnostic technologies by integrating available virus detection methods and utilizing interdisciplinary research to design novel diagnostic tools and enhance detection efficiency.
Article
Pediatrics
Uche Ogunna, Syed Mohinuddin, Nandiran Ratnavel, Anne Greenough, Theodore Dassios
Summary: This study aimed to investigate the impact of hypothermia during the transfer of extremely low birth weight infants on morbidity and mortality. The results showed that hypothermia was common during the transfer process and was associated with longer duration of ventilation and increased mortality during neonatal care.
Review
Critical Care Medicine
David M. Maslove, Stephanie Sibley, J. Gordon Boyd, Ewan C. Goligher, Laveena Munshi, Isaac I. Bogoch, Bram Rochwerg
Summary: Patients admitted to the ICU with critical COVID-19 often require prolonged mechanical ventilation, which may result in ventilator-induced lung and diaphragmatic injuries. Difficult weaning, slow progress, and clinical deterioration are commonly encountered in these patients during the recovery process.
Editorial Material
Anesthesiology
Tommaso Scquizzato, Alice Hutin, Giovanni Landoni
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Juliette Brehat, Mathieu Panel, Bijan Ghaleh, Didier Morin
Summary: This study evaluated the effectiveness of the Ca2+ electrogenic ionophore ferutinin as a tool to induce mitochondrial permeability transition pore (mPTP) in cardiomyocytes. The results showed that while ferutinin can induce mPTP formation, it does not act solely through CypD-dependent mPTP opening. Therefore, ferutinin is not suitable for studying the effects of CypD-dependent mPTP in isolated cardiomyocytes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Valerie Chetboul, Pauline Bernard, Peggy Passavin, Renaud Tissier
Summary: This retrospective study analyzed the results of a 17-year cardiovascular breed screening program for Boxer dogs in France. The findings showed that during this period, 93.8% of the dogs were detected with aortic stenosis (AS) and 94.5% were detected with pulmonic stenosis (PS). The prevalence of AS and PS in Boxer dogs decreased at the studied cardiology center over time.
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Cardiac & Cardiovascular Systems
Bijan Ghaleh, Ines Barthelemy, Lucien Sambin, Alain Bize, Daphne Corboz, Luc Hittinger, Stephane Blot, Jin Bo Su
Summary: The study used two-dimensional speckle tracking echocardiography to analyze the non-uniformity of myocardial strain in golden retriever muscular dystrophy (GRMD) dogs. The results showed spatial and temporal heterogeneity in the myocardial strain, providing new insights into the progression of dystrophin-deficient cardiomyopathy.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Alexandre Loupy, Valentin Goutaudier, Alessia Giarraputo, Fariza Mezine, Erwan Morgand, Blaise Robin, Karen Khalil, Sapna Mehta, Brendan Keating, Amy Dandro, Anais Certain, Pierre-Louis Tharaux, Navneet Narula, Renaud Tissier, Sebastien Giraud, Thierry Hauet, Harvey Pass, Aurelie Sannier, Ming Wu, Adam Griesemer, David Ayares, Vasishta Tatapudi, Jeffrey Stern, Carmen Lefaucheur, Patrick Bruneval, Massimo Mangiola, Robert A. Montgomery
Summary: We conducted a comprehensive phenotyping of pig kidney xenografts transplanted to deceased humans. Our findings suggest early signs of antibody-mediated rejection, characterized by microvascular inflammation, endothelial cell activation, and positive xenoreactive crossmatches.
Article
Medicine, General & Internal
Oscar Demeulenaere, Philippe Mateo, Rene Ferrera, Paul-Mathieu Chiaroni, Alain Bize, Jianping Dai, Lucien Sambin, Romain Gallet, Mickael Tanter, Clement Papadacci, Bijan Ghaleh, Mathieu Pernot
Summary: This study developed an approach to directly image and quantify coronary microvascular obstruction and no-reflow in large mammal perfused hearts. This is the first noninvasive, quantitative, and affordable method for assessing alterations of the microvascular network in myocardial infarction.
Article
Gastroenterology & Hepatology
Amel Kheyar, Nazim Ahnou, Abdelhakim Ahmed-Belkacem, Anne Hulin, Claire Pressiat, Bijan Ghaleh, Jean-Francois Guichou, Didier Morin, Jean-Michel Pawlotsky, Fatima Teixeira-Clerc
Summary: This study identified a novel cyclophilin inhibitor with strong mitoprotective properties both in vitro and in vivo, which represents a promising candidate for cellular protection in hepatic ischaemia-reperfusion injury.
Article
Medicine, Research & Experimental
Joel Lemaire, Michel Heninger, Essyllt Louarn, Ira Katz, Renaud Tissier, Matthieu Chalopin, Geraldine Farjot, Aude Milet
Summary: This paper presents a technique based on mass spectrometry for measuring argon solubility in liquids, including blood, which can be used in pharmacokinetics testing of argon. Results from sensitivity experiments using ambient air, water, and rabbit blood are reported based on a prototype, showing that the system was sensitive to argon during all of the testing. The authors believe that the technique and prototype of the quadrupole mass spectrometer gas analyzer will be capable of inferring argon pharmacokinetics through the analysis of blood samples.
MEDICAL GAS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Romain Gallet, Jin-Bo Su, Daphne Corboz, Paul-Matthieu Chiaroni, Alain Bize, Jianping Dai, Mathieu Panel, Pierre Boucher, Gaetan Pallot, Juliette Brehat, Lucien Sambin, Guillaume Thery, Nadir Mouri, Aurelien de Pommereau, Pierre Denormandie, Stephane Germain, Alain Lacampagne, Emmanuel Teiger, Eduardo Marban, Bijan Ghaleh
Summary: Heart failure with preserved ejection fraction (HFpEF) is a major public health concern, and there are currently very few treatments available to improve its outcomes. Cardiosphere-derived cells (CDCs) have shown promise in improving left ventricular structure and function in pigs with HFpEF.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yara Abi Zeid Daou, Hakim Hocini, Emilie Boissady, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cecile Lefebre, Bijan Ghaleh, Renaud Tissier
Meeting Abstract
Cardiac & Cardiovascular Systems
Estelle Faucher, Lidouren Fanny, Yara Abi Zeid Daou, Bijan Ghaleh, Renaud Tissier, Matthias Kohlhauer
Article
Critical Care Medicine
Arnaud Lesimple, Caroline Fritz, Alice Hutin, Emmanuel Charbonney, Dominique Savary, Stephane Delisle, Paul Ouellet, Gilles Bronchti, Fanny Lidouren, Thomas Piraino, Francois Beloncle, Nathan Prouvez, Alexandre Broc, Alain Mercat, Laurent Brochard, Renaud Tissier, Jean-Christophe Richard
Summary: The capnogram obtained during CPR can help identify thoracic distension and airway closure, and thoracic distension has a negative impact on gas exchange and hemodynamics during CPR.