Article
Public, Environmental & Occupational Health
Anna Deal, Sally E. Hayward, Alison F. Crawshaw, Lucy P. Goldsmith, Charles Hui, Warren Dalal, Fatima Wurie, Mary-Ann Bautista, May Antonnette Lebanan, Sweetmavourneen Agan, Farah Amin Hassan, Kolitha Wickramage, Ines Campos-Matos, Sally Hargreaves
Summary: The immunization coverage of refugees in UK resettlement programs varies by nationality and age, with particularly low coverage for diphtheria and tetanus, and among adult refugees. These findings highlight the importance of improving pre-entry health assessments and vaccination policies for refugees.
LANCET PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Rajesh Sharma
Summary: Breast cancer is the leading malignancy in African females, causing 74,072 deaths and 168,690 cases in 2018. Nigeria has the highest burden with 26,310 cases and 11,564 deaths. The main challenges in tackling breast cancer in Africa include late-stage disease presentation, lack of screening and therapeutic infrastructure, lack of awareness, and limited resources.
JOURNAL OF PUBLIC HEALTH
(2021)
Review
Immunology
Bella Guerrouahen, Muhammad Elnaggar, Anjud Al-Mohannadi, Dhanya Kizhakayil, Chiara Bonini, Reuben Benjamin, Renier Brentjens, Christian J. Buchholz, Giulia Casorati, Soldano Ferrone, Frederick L. Locke, Francisco Martin, Axel Schambach, Cameron Turtle, Paul Veys, Hans J. van der Vliet, Cristina Maccalli
Summary: The progress in isolating and characterizing tumor antigen-specific T lymphocytes, as well as genetically modifying immune cells, has led to the clinical development of adoptive cell therapy. The approval of CAR-T cells targeting CD19(+) B cell malignancies represents a breakthrough in immunotherapy, demonstrating significant clinical activity. Advances in manufacturing and gene editing of immune cells have helped in selecting drug products with desired characteristics, specificity, and reduced toxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Harry Hill, Ben Kearns, Nora Pashayan, Cristina Roadevin, Peter Sasieni, Judith Offman, Stephen Duffy
Summary: Risk-stratified breast cancer screening has the potential to be beneficial for women at the population level, but the net health benefit will depend on the particular risk-based strategy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Toral Gathani, Anushka Chaudhry, Leena Chagla, Sharat Chopra, Ellen Copson, Arnie Purushotham, Raghavan Vidya, Ramsey Cutress
Summary: Outcomes for women with breast cancer in the UK have significantly improved in recent decades, largely due to early diagnosis and free treatments provided by the National Health Service. Concerns exist that ethnic minority groups, making up around 15% of the UK population, may experience poorer outcomes. This report aims to summarize current evidence on breast cancer incidence and outcomes in ethnic minority women in the UK to raise awareness and identify areas for future research.
Review
Cell Biology
Howard R. Petty
Summary: While great effort has been made to understand the origins of cancer, less attention has been given to the primary cause of cancer deaths - cancer recurrences and their consequences. This interdisciplinary review explores the mechanisms of aggressive cancer by studying metabolic enzyme patterns in ductal carcinoma in situ (DCIS) of the breast lesions. The study found that machine learning can accurately identify biomarker patterns associated with cancer recurrence, providing a new prognostic test to predict the likelihood of recurrence in patients with DCIS.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Karol Biernacki, Olga Ciupak, Mateusz Dasko, Janusz Rachon, Witold Kozak, Janusz Rak, Konrad Kubinski, Maciej Maslyk, Aleksandra Martyna, Magdalena Sliwka-Kaszynska, Joanna Wietrzyk, Marta Switalska, Alessio Nocentini, Claudiu T. Supuran, Sebastian Demkowicz
Summary: This research presents the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potential steroid sulfatase (STS) inhibitors for breast cancer treatment. The compounds showed promising inhibitory activity in in vitro and in vivo assays, with compound 5l demonstrating the most potent inhibition in MCF-7 cells and compound 4b showing significant tumor growth inhibition without side effects or toxicity in a mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Samuel Espana, Daniel Sanchez-Parcerisa, Paloma Bragado, Alvaro Gutierrez-Uzquiza, Almudena Porras, Carolina Gutierrez-Neira, Andrea Espinosa, Victor V. Onecha, Paula Ibanez, Victor Sanchez-Tembleque, Jose M. Udias, Luis M. Fraile
Summary: This study investigates the possibility of using O-18-enriched water (18-W) as a contrast agent for range verification in clinical protontherapy. The results showed that low-energy protons can indeed produce a detectable PET signal if a suitable contrast agent is employed. Compared to previous methods, 18-W can generate a higher PET signal inside the living organism and prolong the retention time of F-18 trapped inside cells.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Elena Sultova, C. Benedikt Westphalen, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Doris Mayr, Martina Rudelius, Steffen Ormanns, Volker Heinemann, Klaus H. Metzeler, Philipp A. Greif, Anna Hester, Sven Mahner, Nadia Harbeck, Rachel Wuerstlein
Summary: The establishment of a Molecular Tumor Board to provide personalized treatment recommendations based on molecular diagnostics has shown to be beneficial for metastatic breast cancer patients, with a high percentage of tumors having actionable genetic alterations and a significant number of patients experiencing clinical benefit from targeted therapies recommended by the board.
Article
Oncology
Halle C. F. Moore, William E. Barlow, George Somlo, Julie R. Gralow, Anne F. Schott, Daniel F. Hayes, Peter Kuhn, James B. Hicks, Lisa Welter, Philip A. Dy, Christina H. Yeon, Alison K. Conlin, Ernie Balcueva, Danika L. Lew, Debasish Tripathy, Lajos Pusztai, Gabriel N. Hortobagyi
Summary: This study evaluated the effectiveness of combination therapy in the first-line treatment of hormone receptor-positive, HER2-negative breast cancer. However, the results showed that combination treatment did not improve progression-free survival or overall survival. In addition, baseline circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) were associated with prognosis.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Young-jin Lee, Tae-Kyung Yoo, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Sae Byul Lee
Summary: The purpose of this study was to analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods and identify factors associated with outcomes and changes in survival after recurrence. The study found that the survival outcomes of Korean patients with breast cancer after the first recurrence have improved, possibly due to advances in treatment.
Article
Medicine, General & Internal
Marcela Carausu, Matthieu Carton, Veronique Dieras, Thierry Petit, Severine Guiu, Anthony Goncalves, Paule Augereau, Jean Marc Ferrero, Christelle Levy, Mony Ung, Isabelle Desmoulins, Marc Debled, Thomas Bachelot, Barbara Pistilli, Jean-Sebastien Frenel, Audrey Mailliez, Michael Chevrot, Luc Cabel
Summary: Evidence suggests that patients with HR+/ERBB2+ metastatic breast cancer have different clinical characteristics and outcomes. The association of HR status and first-line inclusion of ET with outcomes among patients with ERBB2+ MBC was evaluated. ET-containing first-line regimens may be associated with benefits in a subgroup of patients with HR+/ERBB2+ MBC.
Article
Public, Environmental & Occupational Health
Bahaty Riogi, Carlo Ross, Miriam Mutebi, Rajiv Dave
Summary: Global health education faces a paradox where high-income countries offer degrees focusing on low-income and middle-income countries' challenges, while experts in these countries lack access to share their expertise. Breast cancer is highlighted as a global health priority demanding curriculum design and leadership by those directly affected. The Kenya-UK Health Alliance aims to address Kenya's breast cancer challenge through collaboration, with initiatives like a breast cancer awareness week led by Kenyan stakeholders paving the way for inclusive educational design in global health ventures.
Article
Oncology
Lauren McVicker, Christopher R. Cardwell, Stuart A. McIntosh, Una C. McMenamin
Summary: Epidemiological studies have shown a higher prevalence of hypothyroidism in breast cancer patients, which may be related to shared risk factors and breast cancer treatments. This study aimed to determine the association between hypothyroidism and breast cancer-specific and all-cause mortality.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Armando Vargas-Palacios, Nisha Sharma, Gurdeep S. Sagoo
Summary: The UK NHS Women's National Breast Screening programme uses double-reading by qualified radiology staff and independent arbitration to detect breast cancer early. However, this labor-intensive process adds pressure to a system already facing a workforce crisis. A simulation model evaluating the potential value of artificial intelligence as a second reader in the NHS suggests that it can be a viable and potentially cost-effective use of resources if non-inferiority is maintained.
NATURE COMMUNICATIONS
(2023)
