Cyclic Di-adenosine Monophosphate Regulates Metabolism and Growth in the Oral Commensal Streptococcus mitis

Increased intracellular cyclic di-AMP levels impair growth and virulence of Bacillus anthracis

(2020) Jia Hu et al.   JOURNAL OF BACTERIOLOGY

c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria

(2020) Andreas Latoscha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased intracellular cyclic-di-AMP levels sensitize Streptococcus gallolyticus subsp. gallolyticus to osmotic stress, and reduce biofilm formation and adherence on intestinal cells

(2019) Wooi Keong Teh et al.   JOURNAL OF BACTERIOLOGY

Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM

(2019) Tommaso Tosi et al.   PLoS Pathogens

The Second Messenger c-di-AMP Regulates Diverse Cellular Pathways Involved in Stress Response, Biofilm Formation, Cell Wall Homeostasis, SpeB Expression, and Virulence in Streptococcus pyogenes

(2019) Tazin Fahmi et al.   INFECTION AND IMMUNITY

Crystal structures of the c-di-AMP synthesizing enzyme CdaA

(2019) Jana L. Heidemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Predominant Oral Microbiota Is Acquired Early in an Organized Pattern

(2019) Rosalyn M. Sulyanto et al.   Scientific Reports

The bacterial second messenger cyclic di-AMP modulates the competence state in Streptococcus pneumoniae

(2019) Tiffany M. Zarrella et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation inStaphylococcus aureusbut dispensable for viability in anaerobic conditions

(2018) Merve S. Zeden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity

(2018) Pengyan Xia et al.   NATURE IMMUNOLOGY

Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus

(2018) Laura Devaux et al.   PLoS Genetics

Streptococcus mitis/oralis Causing Blood Stream Infections in Pediatric Patients

(2018) Sevgen Tanır Basaranoglu et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Biological and Biochemical Roles of Two Distinct Cyclic Dimeric Adenosine 3′,5′-Monophosphate- Associated Phosphodiesterases in Streptococcus mutans

(2018) Hiroyasu Konno et al.   Frontiers in Microbiology

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State

(2017) Adelle P. McFarland et al.   IMMUNITY

c-di-AMP modulatesListeria monocytogenescentral metabolism to regulate growth, antibiotic resistance and osmoregulation

(2017) Aaron T. Whiteley et al.   MOLECULAR MICROBIOLOGY

Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima

(2017) David Jan Drexler et al.   STRUCTURE

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae

(2017) Cedric Blötz et al.   Frontiers in Microbiology

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

(2016) Warrison A. Andrade et al.   Cell Host & Microbe

Effects of diadenylate cyclase deficiency on synthesis of extracellular polysaccharide matrix of Streptococcus mutans revisit

(2016) Xian Peng et al.   ENVIRONMENTAL MICROBIOLOGY

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance inStaphylococcus aureus

(2016) Lisa Bowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis inStreptococcus pneumoniae

(2016) Kirsten Kuipers et al.   MOLECULAR MICROBIOLOGY

Overcoming the Barrier of Low Efficiency during Genetic Transformation of Streptococcus mitis

(2016) Gabriela Salvadori et al.   Frontiers in Microbiology

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp

(2015) Aaron T. Whiteley et al.   Cell Host & Microbe

Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in S treptococcus mutans

(2015) Xingqun Cheng et al.   ENVIRONMENTAL MICROBIOLOGY

Diadenylate cyclase evaluation of ssDacA (SSU98_1483) in Streptococcus suis serotype 2

(2015) B. Du et al.   GENETICS AND MOLECULAR RESEARCH

Functional Analysis of a c-di-AMP-specific Phosphodiesterase MsPDE from Mycobacterium smegmatis

(2015) Qing Tang et al.   International Journal of Biological Sciences

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP

(2015) Colleen A. Kellenberger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

(2015) TuAnh Ngoc Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function

(2014) Kamakshi Sureka et al.   CELL

DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

(2014) Meiping Ye et al.   INFECTION AND IMMUNITY

Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2

(2014) Bin Du et al.   MICROBIOLOGICAL RESEARCH

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

SMART: recent updates, new developments and status in 2015

(2014) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

Parallel Evolution of Streptococcus pneumoniae and Streptococcus mitis to Pathogenic and Mutualistic Lifestyles

(2014) M. Kilian et al.   mBio

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence

(2013) Kyu Hong Cho et al.   PLoS One

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

(2012) Yinlan Bai et al.   PLoS One

Competence in Streptococcus pneumoniae Is Regulated by the Rate of Ribosomal Decoding Errors

(2011) K. E. Stevens et al.   mBio

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Evolution of Streptococcus pneumoniae and Its Close Commensal Relatives

(2008) Mogens Kilian et al.   PLoS One

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling