The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp (vol 17, pg 788, 2015)

Summary: The production and degradation of cyclic diadenosine monophosphate (c-di-AMP) play important roles in the growth, environmental adaptation, and infection of the human enteropathogen Clostridioides difficile. The production of c-di-AMP is essential for growth, potassium uptake, biofilm formation, and cell wall homeostasis, while its degradation is required for osmotolerance and resistance to detergents and bile salts. Additionally, c-di-AMP degradation is important for host colonization.

Summary: This study analysed the in-hospital and early mortality of adults after recovery from severe infection caused by Listeria monocytogenes and identified the main factors associated with early mortality. The findings are important for improving preventive and follow-up strategies for adults with severe listeriosis.

Summary: Listeria monocytogenes produces c-di-AMP and c-di-GMP as important regulators, and NrnA plays a role in maintaining the homeostasis of these nucleotides by hydrolyzing them to linear dinucleotides. The absence of NrnA impairs the infection ability of L. monocytogenes in mammalian cells, suggesting that accumulated linear dinucleotides inhibit the expression or function of virulence factors.

Summary: The study revealed that Centella asiatica extract could be used as a food preservative in fresh-cut fruits and vegetables to retard browning, but it was less effective in reducing bacterial growth. Further research is needed to explore its full potential in food preservation.