Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro

Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome

(2020) Gabsik Yang et al.   Biomolecules & Therapeutics

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

(2020) Cheng Zeng et al.   Redox Biology

Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages

(2020) Sara Staples et al.   LIFE SCIENCES

The Gut Microbiota and Its Metabolites, Novel Targets for Treating and Preventing Non‐Alcoholic Fatty Liver Disease

(2020) Yinhua Ni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

(2020) Jana Knorr et al.   SEMINARS IN LIVER DISEASE

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

(2020) Daniela Maria Tanase et al.   Journal of Diabetes Research

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

(2020) Hyun Hwangbo et al.   Biomolecules & Therapeutics

Native low density lipoprotein increases the production of both nitric oxide and reactive oxygen species in the human umbilical vein endothelial cells

(2019) Hyun Joong Yoon et al.   Genes & Genomics

Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

(2019) Stephanie B. Wall et al.   Oxidative Medicine and Cellular Longevity

Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease

(2019) Carolina M. Perdomo et al.   Nutrients

Repurposing drugs as pro‐oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

(2019) Stephen J. Ralph et al.   MEDICINAL RESEARCH REVIEWS

The Thioredoxin Reductase Inhibitor Auranofin Induces Heme Oxygenase-1 in Lung Epithelial Cells Via Nrf2-dependent Mechanisms

(2018) Katelyn Dunigan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease

(2018) Bangling Zhang et al.   FASEB JOURNAL

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Caffeic acid ameliorates hepatic steatosis and decreased endoplasmic reticulum stress in high-fat diet-induced obese mice by regulating autophagy

(2018) Hong Min Kim et al.   NUTRITION

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

(2018) Ramy Younes et al.   Nature Reviews Gastroenterology & Hepatology

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Pathology of non-alcoholic fatty liver disease

(2017) Pierre Bedossa   LIVER INTERNATIONAL

Modelling immune–microbe interaction in 3D intestinal culture

(2017) Hugh Thomas   Nature Reviews Gastroenterology & Hepatology

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

(2017) So Yeon Kim et al.   Nature Communications

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Biomarkers in Nonalcoholic Fatty Liver Disease

(2016) Manuela G Neuman et al.   Canadian Journal of Gastroenterology and Hepatology

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

A new look at auranofin, dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases

(2015) Andis Klegeris et al.   Neural Regeneration Research

Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin

(2014) Elina Isakov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Extrahepatic complications of nonalcoholic fatty liver disease

(2013) Matthew J. Armstrong et al.   HEPATOLOGY

Nickel Induces Interleukin-1β Secretion via the NLRP3–ASC–Caspase-1 Pathway

(2013) Xiujin Li et al.   INFLAMMATION

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Developmental origins of nonalcoholic fatty liver disease

(2013) David E. Brumbaugh et al.   PEDIATRIC RESEARCH

Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

(2012) Morgan L. Locy et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer

(2012) Zsuzsanna Ament et al.   Genome Medicine

The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils

(2011) Arun K. Mankan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

(2010) Judith Ertle et al.   INTERNATIONAL JOURNAL OF CANCER

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

(2008) Elizabeth M. Brunt et al.   HEPATOLOGY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR