MicroRNAs: Diverse Mechanisms of Action and Their Potential Applications as Cancer Epi-Therapeutics

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

(2019) Tiia A. Turunen et al.   Scientific Reports

MicroRNA Regulation of Epigenetic Modifiers in Breast Cancer

(2019) Brock Humphries et al.   Cancers

Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer

(2018) Hongyu Liu et al.   Molecular Cancer

Epigenetics and Epi-miRNAs: Potential markers/therapeutics in leukemia

(2018) Fatemeh Memari et al.   BIOMEDICINE & PHARMACOTHERAPY

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential mechanisms of microRNA mobility

(2018) Heiko Lemcke et al.   TRAFFIC

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

The Network of Non-coding RNAs in Cancer Drug Resistance

(2018) Fabio Corrà et al.   Frontiers in Oncology

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha

(2017) Jessica J. Chaston et al.   PLoS One

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

(2016) Lingling Miao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer

(2016) Alexander A. Svoronos et al.   CANCER RESEARCH

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

(2016) Caterina Catalanotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP

(2016) Ryan M. Spengler et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

(2016) Min Xiao et al.   RNA Biology

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells

(2016) B Cardinali et al.   Cell Death & Disease

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

(2016) Glen Reid et al.   Epigenomics

The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma

(2016) Yusuke Goto et al.   Oncotarget

Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): inhibition of bladder cancer cell aggressiveness

(2016) Ryosuke Matsushita et al.   Oncotarget

H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA

(2016) Wei-Cheng Liang et al.   Scientific Reports

A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation

(2015) Gang Xue et al.   CANCER LETTERS

Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis

(2015) Mingchen Zhu et al.   CANCER SCIENCE

miR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1

(2015) Xinsheng Wang et al.   FEBS Journal

Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling

(2015) Fei Jiang et al.   MOLECULAR CARCINOGENESIS

miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1

(2015) Alan P. Lombard et al.   MOLECULAR CARCINOGENESIS

Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs

(2015) Myung Hyun Jo et al.   MOLECULAR CELL

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

(2015) Daniel Schraivogel et al.   NUCLEIC ACIDS RESEARCH

Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer

(2015) Mina Zamani et al.   PHYTOMEDICINE

Modulation of Splicing by Single-Stranded Silencing RNAs

(2015) Jing Liu et al.   Nucleic Acid Therapeutics

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies

(2015) Nicola Amodio et al.   Oncotarget

Deregulation between miR-29b/c and DNMT3A Is Associated with Epigenetic Silencing of the CDH1 Gene, Affecting Cell Migration and Invasion in Gastric Cancer

(2015) He Cui et al.   PLoS One

MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells

(2015) Yosuke Konno et al.   Oncotarget

MicroRNA binding sites in the coding region of mRNAs: Extending the repertoire of post-transcriptional gene regulation

(2014) Anneke Brümmer et al.   BIOESSAYS

MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines

(2014) Masoumeh Azizi et al.   CANCER BIOLOGY & THERAPY

MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer

(2014) Mei-Yi Wu et al.   CANCER LETTERS

miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents

(2014) Volker Baumann et al.   Future Medicinal Chemistry

MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression

(2014) Wen Hao Neo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin 8 Regulates the Transport of Mature MicroRNAs into the Cell Nucleus

(2014) Yao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1

(2014) Jiang Yan et al.   MEDICAL ONCOLOGY

Quantitative Nuclear Proteomics Identifies that miR-137-mediated EZH2 Reduction Regulates Resveratrol-induced Apoptosis of Neuroblastoma Cells

(2014) Xiaoqing Ren et al.   MOLECULAR & CELLULAR PROTEOMICS

miR-185 Suppresses Tumor Proliferation by Directly Targeting E2F6 and DNMT1 and Indirectly Upregulating BRCA1 in Triple-Negative Breast Cancer

(2014) H. Tang et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

(2014) Akira Fukao et al.   MOLECULAR CELL

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

(2014) Ryan L. Boudreau et al.   NEURON

A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs

(2014) Anna Sadakierska-Chudy et al.   NEUROTOXICITY RESEARCH

A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants

(2014) Anna Sadakierska-Chudy et al.   NEUROTOXICITY RESEARCH

MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway

(2014) T Yu et al.   ONCOGENE

Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells

(2014) JIAN-ZHEN SHEN et al.   ONCOLOGY REPORTS

Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs

(2014) Yijun Zhang et al.   RNA

Import routes and nuclear functions of Argonaute and other small RNA-silencing proteins

(2014) Daniel Schraivogel et al.   TRENDS IN BIOCHEMICAL SCIENCES

EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications

(2014) Enyu Dai et al.   Database-The Journal of Biological Databases and Curation

A miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor

(2014) Bi-Feng Chen et al.   Scientific Reports

MicroRNA-206 suppresses gastric cancer cell growth and metastasis

(2014) Jun Ren et al.   Cell and Bioscience

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

(2014) Ayla Valinezhad Orang et al.   International Journal of Genomics

MiR-32 Functions as a Tumor Suppressor and Directly Targets EZH2 in Human Oral Squamous Cell Carcinoma

(2014) Jin Xiao   MEDICAL SCIENCE MONITOR

The MicroRNA Biology of the Mammalian Nucleus

(2014) Thomas C Roberts   Molecular Therapy-Nucleic Acids

Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma

(2013) N Nohata et al.   BRITISH JOURNAL OF CANCER

MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

(2013) Ji Heon Noh et al.   CANCER LETTERS

Downregulation of miR-217 correlates with resistance of ph+leukemia cells to ABL tyrosine kinase inhibitors

(2013) Chie Nishioka et al.   CANCER SCIENCE

Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia

(2013) X. Huang et al.   CLINICAL CANCER RESEARCH

Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis

(2013) Lin Zhou et al.   FASEB JOURNAL

miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling

(2013) Yuwen Guo et al.   FEBS Journal

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A

(2013) Kristina Althoff et al.   INTERNATIONAL JOURNAL OF CANCER

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells

(2013) Pierpaolo Peruzzi et al.   NEURO-ONCOLOGY

MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine

(2013) Y Xiang et al.   ONCOGENE

miR-203 Inhibits the Proliferation and Self-Renewal of Esophageal Cancer Stem-Like Cells by Suppressing Stem Renewal Factor Bmi-1

(2013) Xiying Yu et al.   STEM CELLS AND DEVELOPMENT

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

(2013) Eleonora Leucci et al.   Scientific Reports

miR-200c Inhibits Melanoma Progression and Drug Resistance through Down-Regulation of Bmi-1

(2012) Shujing Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

(2012) Y. Li et al.   BLOOD

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

(2012) G. Zardo et al.   BLOOD

Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer

(2012) Joana Carvalho et al.   JOURNAL OF PATHOLOGY

miRNAs and cancer: An epigenetics view

(2012) Marcos Malumbres   MOLECULAR ASPECTS OF MEDICINE

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

(2012) Joerg E Braun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex

(2012) T. Shimakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

MicroRNA-mediated mRNA Translation Activation in Quiescent Cells and Oocytes Involves Recruitment of a Nuclear microRNP

(2012) S. S. Truesdell et al.   Scientific Reports

MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1

(2011) Hui Wang et al.   CARCINOGENESIS

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

Reduced miR-128 in Breast Tumor-Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5

(2011) Y. Zhu et al.   CLINICAL CANCER RESEARCH

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

(2011) Ji-hang Yuan et al.   HEPATOLOGY

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear and cytoplasmic localization of neural stem cell microRNAs

(2011) C. D. Jeffries et al.   RNA

microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia

(2010) A. M. Roccaro et al.   BLOOD

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

(2010) J Zhang et al.   BRITISH JOURNAL OF CANCER

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer

(2010) Shahana Majid et al.   CANCER

MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation

(2010) S. Das et al.   CANCER RESEARCH

Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs

(2010) Susana Gonzalez et al.   CELL CYCLE

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

MicroRNA mir-346 targets the 5′-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression

(2009) Nien-Pei Tsai et al.   BIOCHEMICAL JOURNAL

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

MicroRNA 29b functions in acute myeloid leukemia

(2009) R. Garzon et al.   BLOOD

Transcriptional inhibition of Hoxd4 expression by noncoding RNAs in human breast cancer cells

(2009) Yuliang Tan et al.   BMC MOLECULAR BIOLOGY

MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer

(2009) E K O Ng et al.   BRITISH JOURNAL OF CANCER

MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer

(2009) R. Bhattacharya et al.   CANCER RESEARCH

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes

(2009) Chiara Braconi et al.   HEPATOLOGY

An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210

(2009) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE