Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway

(2018) Mohammad Azimi et al.   PEPTIDES

Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial

(2018) Sarah E Lamb et al.   BMJ-British Medical Journal

Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial

(2018) Sarah E Lamb et al.   BMJ-British Medical Journal

Can lifestyle changes prevent cognitive impairment?

(2017) Miia Kivipelto et al.   LANCET NEUROLOGY

Health benefits of exercise — more than meets the eye!

(2017) Mark A. Febbraio   Nature Reviews Endocrinology

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

(2017) Jill K. Morris et al.   PLoS One

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle

(2016) B. M. Varela-Rodríguez et al.   Scientific Reports

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease

(2015) Cheril Tapia-Rojas et al.   BRAIN PATHOLOGY

Fndc5overexpression facilitated neural differentiation of mouse embryonic stem cells

(2015) Mahboobeh Forouzanfar et al.   CELL BIOLOGY INTERNATIONAL

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Physical Activity Level and Future Risk of Mild Cognitive Impairment or Dementia

(2015) Gretchen E. Schlosser Covell et al.   NEUROLOGIST

Effect of carnosine, methylprednisolone and their combined application on irisin levels in the plasma and brain of rats with acute spinal cord injury

(2015) Serdal Albayrak et al.   NEUROPEPTIDES

Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

(2014) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cerebral amyloid PET imaging in Alzheimer’s disease

(2013) Clifford R. Jack et al.   ACTA NEUROPATHOLOGICA

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

(2013) Suna Aydin et al.   PEPTIDES

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

(2013) Satoru Funamoto et al.   Nature Communications

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library

(2011) Brian G. Pierce et al.   PLoS One

PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

(2010) Vitor A. Lira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

(2010) Kelvin Y. Liang et al.   ANNALS OF NEUROLOGY

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

(2010) Kengo Uemura et al.   Nature Communications

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

(2009) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

(2009) Tomoko Kuwabara et al.   NATURE NEUROSCIENCE

Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology

(2008) Arne Herring et al.   EXPERIMENTAL NEUROLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation