Review
Cardiac & Cardiovascular Systems
Carina Mauersberger, Julia Hinterdobler, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager
Summary: This article comprehensively reviews the process of leukocyte recruitment relevant to atherosclerosis, with a focus on endothelial cells, monocytes and macrophages, neutrophils, T lymphocytes and platelets. Therapeutic options targeting leukocyte recruitment into atherosclerotic lesions, as well as potential insights into its precise mechanisms, are also highlighted.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eiji Kawamoto, Nodoka Nago, Takayuki Okamoto, Arong Gaowa, Asami Masui-Ito, Yuichi Akama, Samuel Darkwah, Michael Gyasi Appiah, Phyoe Kyawe Myint, Gideon Obeng, Atsushi Ito, Siqingaowa Caidengbate, Ryo Esumi, Takanori Yamaguchi, Eun Jeong Park, Hiroshi Imai, Motomu Shimaoka
Summary: Thrombomodulin has been found to inhibit the binding of human breast cancer-derived cell lines to fibronectin by binding to extracellular matrix proteins. Additionally, exogenously administered thrombomodulin fusion protein may be applied at an early stage of inflammation to develop new therapies that inhibit the binding of breast cancer cell lines to fibronectin.
Review
Immunology
Susan Yung, Tak Mao Chan
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus, and early diagnosis and management are crucial. Kidney biopsy remains the gold standard for diagnosis, but it is invasive and cannot be frequently repeated. Current clinical indicators are non-specific, and novel biomarkers are needed for better management.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Soren Egstrand, Maria L. Mace, Klaus Olgaard, Ewa Lewin
Summary: Chronic kidney disease is associated with high cardiovascular mortality and disruption of circadian rhythms in the vasculature, potentially contributing to uremic vasculopathy.
Article
Hematology
Farah Abdel Rahman, Sascha D'Almeida, Tina Zhang, Morad Asadi, Tarik Bozoglu, Dario Bongiovanni, Moritz von Scheidt, Steffen Dietzel, Edzard Schwedhelm, Rabea Hinkel, Karl Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler
Summary: In sepsis, S1P acts as an antagonist to pericyte loss, vascular hyperpermeability, and systemic hypotension, resulting in increased survival in mice. By preserving the deposition of VE-cadherin and N-cadherin, S1P may achieve this effect through reduction of protein phosphorylation and increased nuclear translocation of MRTF-A.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Briana E. Heinly, Christa N. Grant
Summary: Neuroblastoma is a biologically heterogeneous tumor derived from neural crest cells, and its treatment remains challenging. The expression of cell adhesion molecules in neuroblastoma is closely associated with clinical prognosis, and targeted therapies against cell adhesion molecules may represent an innovative treatment strategy in the future.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qianjiang Hu, Komal Saleem, Jyotsana Pandey, Arzoo N. N. Charania, Yong Zhou, Chao He
Summary: The mechanisms of tissue fibrosis pathogenesis are not completely understood. Cell adhesion molecules (CAMs) play critical roles in fibrotic progression in various organs. Dysregulated expression and function of CAMs can lead to chronic inflammation and tissue fibrosis. The major families of CAMs include integrins, cadherins, selectins, and immunoglobulins. In this review, we focus on the role of CAMs, particularly integrins and cadherins, in the development of pulmonary fibrosis.
Article
Hematology
Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi
Summary: The study aims to investigate the role of Gab2 in inflammatory signaling pathways and its contribution to vascular dysfunction. The results show that silencing Gab2 can significantly attenuate the expression of TF, cell adhesion molecules, and inflammatory cytokines/chemokines induced by cytokines.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giacomo S. Amelio, Livia Provitera, Genny Raffaeli, Ilaria Amodeo, Silvia Gulden, Valeria Cortesi, Francesca Manzoni, Nicola Pesenti, Matteo Tripodi, Valentina Pravata, Caterina Lonati, Gaia Cervellini, Fabio Mosca, Giacomo Cavallaro
Summary: This study investigates the perinatal endothelial phenotype in very preterm infants and its predictive value on neonatal mortality and hemodynamic and respiratory complications. The results suggest that very preterm infants have a proinflammatory endothelial phenotype, possibly resulting from a combination of pathological prenatal inheritance and premature extrauterine transition.
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hemant Giri, Sumith R. Panicker, Xiaofeng Cai, Indranil Biswas, Hartmut Weiler, Alireza R. Rezaie
Summary: Deletion of TM in endothelial cells leads to increased basal permeability, enhanced tyrosine phosphorylation of VE-cadherin, reduced F-actin filament polymerization, increased NF-kappa B signaling, expression of inflammatory cell adhesion molecules, von Willebrand factor levels, storage, and release. Reexpression of TM construct normalized the cellular phenotype, suggesting cell-bound TM regulates expression of procoagulant, proinflammatory, and angiogenic molecules in vascular endothelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Physiology
Zhiyuan Li, Shuyan Dong, Shichen Huang, Yuhan Sun, Yingzhi Sun, Beibei Zhao, Qiulan Qi, Lei Xiong, Feng Hong, Yuxin Jiang
Summary: Inflammatory bowel disease (IBD) is an autoimmune disease caused by chronic recurrent inflammation of the ileum, rectum, and colon. CD34 is involved in mediating the migration of various immune cells to the inflammatory site during IBD, and its interaction with adhesion molecules contributes to the occurrence and development of IBD. This article aims to explore the structure, biological function, and potential mechanism of CD34 in IBD.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah
Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Engineering, Biomedical
Asami Ito, Yoshiaki Iwashita, Ryo Esumi, Ken Sasaki, Masahiro Yukimitsu, Takafumi Kato, Eiji Kawamoto, Kei Suzuki, Hiroshi Imai
JOURNAL OF ARTIFICIAL ORGANS
(2020)
Article
Health Care Sciences & Services
Eiji Kawamoto, Asami Ito-Masui, Ryo Esumi, Mami Ito, Noriko Mizutani, Tomoyo Hayashi, Hiroshi Imai, Motomu Shimaoka
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Medicine, General & Internal
Eiji Kawamoto, Asami Ito-Masui, Ryo Esumi, Hiroshi Imai, Motomu Shimaoka
FRONTIERS IN MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Takanori Yamaguchi, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park, Motomu Shimaoka
Summary: Leukemia originates from hematopoietic stem cells in the bone marrow and treatment includes chemotherapy and hematopoietic stem cell transplantation. However, drug resistance and relapse remain challenges in leukemia management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Kaoru Ikejiri, Yuichi Akama, Yohei Ieki, Eiji Kawamoto, Kei Suzuki, Kazuto Yokoyama, Ken Ishikura, Hiroshi Imai
Summary: Cardiotoxicity in tricyclic antidepressant intoxication is a common cause of death. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and targeted temperature management (TTM) have been shown to be effective in treating critically ill poisoned patients. This case report demonstrates the successful use of VA-ECMO and TTM in a patient with tricyclic antidepressant intoxication, leading to a good outcome.
Article
Biochemistry & Molecular Biology
Eiji Kawamoto, Nodoka Nago, Takayuki Okamoto, Arong Gaowa, Asami Masui-Ito, Yuichi Akama, Samuel Darkwah, Michael Gyasi Appiah, Phyoe Kyawe Myint, Gideon Obeng, Atsushi Ito, Siqingaowa Caidengbate, Ryo Esumi, Takanori Yamaguchi, Eun Jeong Park, Hiroshi Imai, Motomu Shimaoka
Summary: Thrombomodulin has been found to inhibit the binding of human breast cancer-derived cell lines to fibronectin by binding to extracellular matrix proteins. Additionally, exogenously administered thrombomodulin fusion protein may be applied at an early stage of inflammation to develop new therapies that inhibit the binding of breast cancer cell lines to fibronectin.
Review
Biochemistry & Molecular Biology
Michael G. Appiah, Eun Jeong Park, Yuichi Akama, Yuki Nakamori, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka
Summary: Sepsis is a systemic inflammatory condition involving multiple organ failures caused by dysregulated immune response to infections. Metabolic reprogramming and immune paralysis are major issues in late mortality. Intercellular metabolic crosstalk through endocrine factors plays a crucial role in maintaining homeostasis in sepsis and other inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Miho Sumiyoshi, Eiji Kawamoto, Yuki Nakamori, Ryo Esumi, Kaoru Ikejiri, Toru Shinkai, Yuichi Akama, Asami Ito-Masui, Hiroshi Imai, Arong Gaowa, Eun Jeong Park, Motomu Shimaoka
Summary: This study found increased levels of sPD-L1 in PCAS, indicating a potential negative impact on immune exhaustion and organ failures through aberrant activation of immune and endothelial cells during ischemia-reperfusion in CPR.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Atsushi Ito, Yuichi Akama, Naoko Satoh-Takayama, Kanako Saito, Takuma Kato, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park, Motoshi Takao, Motomu Shimaoka
Summary: This study investigates the dynamic interactions between innate lymphoid cells (ILC2s) and myeloid-derived suppressor cells (MDSCs) during the progression of breast cancer metastasis to the lung. The results show that ILC2s are activated in both micro- and macro-metastatic regions, suggesting sustained activation throughout the metastatic cascade. Furthermore, ILC2s may induce the immunosuppressive functions of MDSCs during the later stages of metastasis, while also instigating extracellular matrix remodeling by activating PMN-MDSCs during the early stages of metastasis.
Article
Cell Biology
Siqingaowa Caidengbate, Yuichi Akama, Anik Banerjee, Khwanchanok Mokmued, Eiji Kawamoto, Arong Gaowa, Louise D. McCullough, Motomu Shimaoka, Juneyoung Lee, Eun Jeong Park
Summary: In a mouse model of sepsis induced by cecal slurry injection, the expression profile of miRNAs in intestinal epithelial cells (IECs) was found to be altered. These changes may have complex and global effects on gene regulation networks, contributing to the development of sepsis.
Article
Biochemistry & Molecular Biology
Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Koichi Nakamura, Tomohito Hagi, Tomoki Nakamura, Motomu Shimaoka, Akihiro Sudo
Summary: In this study, the researchers aimed to investigate whether increasing the stiffness of osteosarcoma cells using carbenoxolone (CBX) could suppress lung metastasis. The results showed that CBX treatment significantly increased the stiffness of the cells and effectively reduced lung metastasis in mice.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Koichi Nakamura, Tomohito Hagi, Tomoki Nakamura, Motomu Shimaoka, Akihiro Sudo
Summary: Analysis of osteosarcoma cells revealed that cell stiffness plays a crucial role in metastatic potential. Cells with high metastatic potential exhibited lower cell stiffness and actin levels, indicating a correlation between metastatic phenotype, actin status, and cell stiffness. This suggests that evaluating actin dynamics and cell stiffness could be important in predicting metastatic potential and developing new drugs against metastasis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Meeting Abstract
Critical Care Medicine
Takayuki Okamoto, Eiji Kawamoto, Haruki Usuda, Tetsuya Tanaka, Tetsuro Nikai, Kunihiro Asanuma, Koji Suzuki, Motomu Shimaoka, Koichiro Wada
Article
Biochemistry & Molecular Biology
Michael G. Appiah, Eun Jeong Park, Samuel Darkwah, Eiji Kawamoto, Yuichi Akama, Arong Gaowa, Manisha Kalsan, Shandar Ahmad, Motomu Shimaoka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Ryo Esumi, Ayumu Yokochi, Motomu Shimaoka, Eiji Kawamoto
JOURNAL OF MEDICAL CASE REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)