Lipid mediators and biomarkers associated with type 1 diabetes development

Temporal trends in incidence of pediatric type 1 diabetes in Alabama: 2000‐2017

(2019) Tanya A. Correya et al.   PEDIATRIC DIABETES

Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice

(2019) Alexander J. Nelson et al.   JOURNAL OF LIPID RESEARCH

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

(2018) Sofia Pavlou et al.   BMC IMMUNOLOGY

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis

(2017) Carlos Antonio Trindade-da-Silva et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation

(2016) Melody G. Duvall et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)

(2016) Jason W. Ashley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice

(2016) Shuo Niu et al.   JOURNAL OF IMMUNOLOGY

Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

(2016) Thomas B. Thornley et al.   PLoS One

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage

(2015) Efrat Dvash et al.   Nature Communications

Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

(2015) Fernando H. G. Tessaro et al.   Biomed Research International

Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

(2014) Chunyan Tan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

(2014) Robert N. Bone et al.   DIABETES

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families

(2014) Yi-Guang Chen et al.   DIABETES

Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D Development

(2014) Xiaoyong Lei et al.   ENDOCRINOLOGY

A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes

(2014) Stephen T. Ferris et al.   IMMUNITY

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

(2013) Shamina M. Green-Mitchell et al.   PLoS One

Characterization of FKGK18 as Inhibitor of Group VIA Ca2+-Independent Phospholipase A2 (iPLA2β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

(2013) Tomader Ali et al.   PLoS One

Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy

(2013) Xiaoyong Lei et al.   Islets

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Smooth Muscle-specific Expression of Calcium-independent Phospholipase A2β (iPLA2β) Participates in the Initiation and Early Progression of Vascular Inflammation and Neointima Formation

(2012) Shu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination Therapy of an Inhibitor of Group VIA Phospholipase A 2 with Paclitaxel Is Highly Effective in Blocking Ovarian Cancer Development

(2011) Hui Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Progressive Erosion of  -Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes

(2011) D. Ize-Ludlow et al.   DIABETES

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

(2011) T. C. Thayer et al.   DIABETES

Eicosanoids, β-cell function, and diabetes

(2011) Pengcheng Luo et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Reduced conduction reserve in the diabetic rat heart: role of iPLA2 activation in the response to ischemia

(2010) Parisa Rahnema et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils

(2010) S. Ayilavarapu et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

(2010) H. M. Tse et al.   JOURNAL OF IMMUNOLOGY

Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2

(2010) George Kokotos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation

(2010) Sang Won Park et al.   LABORATORY INVESTIGATION

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Diabetes in Non-Hispanic White Youth: Prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study

(2009) R. A. Bell et al.   DIABETES CARE

Lipidomic Analysis of Dynamic Eicosanoid Responses during the Induction and Resolution of Lyme Arthritis

(2009) Victoria A. Blaho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2Expression

(2009) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels

(2009) Dayanjan S. Wijesinghe et al.   JOURNAL OF LIPID RESEARCH

Increasing Incidence of Pediatric Type 1 Diabetes Mellitus in Southeastern Wisconsin: Relationship with Body Weight at Diagnosis

(2009) Jennifer Evertsen et al.   PLoS One

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Synthesis of Polyfluoro Ketones for Selective Inhibition of Human Phospholipase A2Enzymes

(2008) Constantinos Baskakis et al.   JOURNAL OF MEDICINAL CHEMISTRY