Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)

The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages

(2016) José Pablo Vázquez-Medina et al.   FASEB JOURNAL

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

(2015) Wojciech J. Grzesik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

(2014) Chunyan Tan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

(2014) Robert N. Bone et al.   DIABETES

Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D Development

(2014) Xiaoyong Lei et al.   ENDOCRINOLOGY

Group VIA Phospholipase A2Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

(2014) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Targeting tumor-infiltrating macrophages to combat cancer

(2013) Roheena Z Panni et al.   Immunotherapy

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

(2013) H. E. Ghoneim et al.   JOURNAL OF IMMUNOLOGY

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

(2013) Shamina M. Green-Mitchell et al.   PLoS One

Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy

(2013) Xiaoyong Lei et al.   Islets

Role of calcium-independent phospholipase A2β in human pancreatic islet β-cell apoptosis

(2012) Xiaoyong Lei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

(2012) Jessica R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Group VIB Phospholipase A2Promotes Proliferation of INS-1 Insulinoma Cells and Attenuates Lipid Peroxidation and Apoptosis Induced by Inflammatory Cytokines and Oxidant Agents

(2012) Shunzhong Bao et al.   Oxidative Medicine and Cellular Longevity

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Managing Macrophages in Rheumatoid Arthritis by Reform or Removal

(2012) Jun Li et al.   Current Rheumatology Reports

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

(2012) Xiu‐Fen Ming et al.   Journal of the American Heart Association

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Role of TNF superfamily ligands in innate immunity

(2011) Nikola L. Vujanovic   IMMUNOLOGIC RESEARCH

Analysis of Two Major Intracellular Phospholipases A2(PLA2) in Mast Cells Reveals Crucial Contribution of Cytosolic PLA2α, Not Ca2+-independent PLA2β, to Lipid Mobilization in Proximal Mast Cells and Distal Fibroblasts

(2011) Noriko Ueno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development

(2010) Hui Li et al.   FASEB JOURNAL

Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils

(2010) S. Ayilavarapu et al.   JOURNAL OF IMMUNOLOGY

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases

(2009) Victoria Magrioti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2Expression

(2009) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling Role for Lysophosphatidylcholine Acyltransferase 3 in Receptor-Regulated Arachidonic Acid Reacylation Reactions in Human Monocytes

(2009) G. Perez-Chacon et al.   JOURNAL OF IMMUNOLOGY

Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells

(2008) María A. Balboa et al.   FEBS Journal

iPLA2β: front and center in human monocyte chemotaxis to MCP-1

(2008) Ravi S. Mishra et al.   JOURNAL OF EXPERIMENTAL MEDICINE