Dendritic Cells and SARS-CoV-2 Infection: Still an Unclarified Connection

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

COVID-19: is the ACE2 just a foe?

(2020) Hrvoje Jakovac   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

(2020) Julia L. McKechnie et al.   Cell Host & Microbe

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19

(2020) Peng Zhang et al.   CIRCULATION RESEARCH

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review

(2020) Nicholas E. Ingraham et al.   EUROPEAN RESPIRATORY JOURNAL

Effects Of ARBs And ACEIs On Virus Infection, Inflammatory Status And Clinical Outcomes In COVID-19 Patients With Hypertension: A Single Center Retrospective Study

(2020) Guang Yang et al.   HYPERTENSION

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

A Review of SARS-CoV-2 and the Ongoing Clinical Trials

(2020) Yung-Fang Tu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein

(2020) Tahir S Pillay   JOURNAL OF CLINICAL PATHOLOGY

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DC/L‐SIGNs of Hope in the COVID‐19 Pandemic

(2020) Adam Brufsky et al.   JOURNAL OF MEDICAL VIROLOGY

Distinct Viral Clades of SARS‐CoV‐2: Implications for Modeling of Viral Spread

(2020) Adam Brufsky   JOURNAL OF MEDICAL VIROLOGY

COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis

(2020) Long‐quan Li et al.   JOURNAL OF MEDICAL VIROLOGY

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

(2020) Javier A. Jaimes et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinical Implications of SARS-Cov2 Interaction with Renin Angiotensin System

(2020) Agnieszka Brojakowska et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

(2020) Elissa Driggin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19

(2020) Litao Zhang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The versatile heparin in COVID‐19

(2020) Jecko Thachil   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses

(2020) Nicola Decaro et al.   VETERINARY MICROBIOLOGY

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers

(2020) Chirag Bavishi et al.   JAMA Cardiology

COVID-19 pathophysiology: A review

(2020) Koichi Yuki et al.   CLINICAL IMMUNOLOGY

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

(2020) Runhong Zhou et al.   IMMUNITY

Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19

(2020) Fang Liu et al.   JOURNAL OF CLINICAL VIROLOGY

Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: A prospective contact-tracing study

(2020) Lei Huang et al.   JOURNAL OF INFECTION

Attenuated Interferon and Proinflammatory Response in SARS-CoV-2–Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation

(2020) Dong Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China

(2020) Dong Chen et al.   JAMA Network Open

The MERS-CoV Receptor DPP4 as a Candidate Binding Target of the SARS-CoV-2 Spike

(2020) Yu Li et al.   iScience

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

(2020) Javier A. Jaimes et al.   iScience

Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

(2019) Lang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pro-inflammatory Cytokines and Resistant Hypertension: Potential for Novel Treatments?

(2019) Mariana Rodrigues Pioli et al.   CURRENT HYPERTENSION REPORTS

IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis

(2018) Chia-Hung Chou et al.   CARDIOVASCULAR RESEARCH

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B

(2018) Coraline Chéneau et al.   JOURNAL OF INFECTIOUS DISEASES

Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II

(2018) Yoshimichi Takeda et al.   Journal of the American Heart Association

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

The Importance of Dendritic Cells in Maintaining Immune Tolerance

(2017) Cindy Audiger et al.   JOURNAL OF IMMUNOLOGY

Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function

(2017) Sophie Laffont et al.   Frontiers in Immunology

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation

(2016) Silvio Antoniak et al.   CARDIOLOGY

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Porcine epidemic diarrhea in China

(2016) Dang Wang et al.   VIRUS RESEARCH

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia

(2015) Ricardo José et al.   LANCET

Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques

(2015) L Liu et al.   Mucosal Immunology

Different Potencies of Angiotensin Receptor Blockers at Suppressing Adrenal β-Arrestin1–Dependent Post-Myocardial Infarction Hyperaldosteronism

(2014) Anastasios Lymperopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

(2014) Hin Chu et al.   VIROLOGY

Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury

(2013) Gerry T. M. Wagenaar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

(2013) Frank Gieseler et al.   Cell Communication and Signaling

DC-SIGN, DC-SIGNR and LSECtin: C-Type Lectins for Infection

(2013) Feng Zhang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

PAR-1 contributes to the innate immune response during viral infection

(2013) Silvio Antoniak et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of Follicular Dendritic Cells to Persistent HIV Viremia

(2013) J. Zhang et al.   JOURNAL OF VIROLOGY

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

(2013) Nancy J. Brown   Nature Reviews Nephrology

Lymphoid follicles in chronic lung diseases

(2013) Koshika Yadava et al.   THORAX

Prediction and prevention of the next pandemic zoonosis

(2012) Stephen S Morse et al.   LANCET

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Aldosterone 'escape' vs 'breakthrough'

(2010) Robert W. Schrier   Nature Reviews Nephrology

Dendritic Cells and HIV-1 Trans-Infection

(2010) David McDonald   Viruses-Basel

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

(2009) Jincun Zhao et al.   PLoS Pathogens

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE