Pro-inflammatory Cytokines and Resistant Hypertension: Potential for Novel Treatments?

Inflammation and Apparent Treatment-Resistant Hypertension in Patients With Chronic Kidney Disease

(2019) Jing Chen et al.   HYPERTENSION

Markers or Makers

(2019) Natalia R. Barbaro et al.   HYPERTENSION

Adaptive Immunity in Hypertension

(2019) Tomasz P. Mikolajczyk et al.   CURRENT HYPERTENSION REPORTS

Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects

(2018) Arthur Santa Catharina et al.   Arquivos Brasileiros de Cardiologia

Effect of infliximab and tocilizumab on fructose-induced hyperinsulinemia and hypertension in rats

(2018) Aly M. Abdelrahman et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association

(2018) Robert M. Carey et al.   HYPERTENSION

Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension

(2017) Ulla Kampmann et al.   Journal of Diabetes Research

The Effect of Renal Denervation on Plasma Adipokine Profile in Patients with Treatment Resistant Hypertension

(2017) Nina Eikelis et al.   Frontiers in Physiology

Tumor Necrosis Factor-α Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis

(2016) Rishi J. Desai et al.   EPIDEMIOLOGY

Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats

(2016) Baorui Huang et al.   Scientific Reports

IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future

(2015) Go Woon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

(2015) S M Krishnan et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effect of renal denervation on endothelial function and inflammatory markers in patients with resistant hypertension

(2015) N. Eikelis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension

(2015) Erdal Belen et al.   Journal of Clinical Hypertension

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Vascular Damage in Resistant Hypertension: TNF-Alpha Inhibition Effects on Endothelial Cells

(2015) Natália Ruggeri Barbaro et al.   Biomed Research International

Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity

(2015) Frank M. Schmidt et al.   PLoS One

Increased arterial stiffness in resistant hypertension is associated with inflammatory biomarkers

(2014) Natália Ruggeri Barbaro et al.   BLOOD PRESSURE

DC isoketal-modified proteins activate T cells and promote hypertension

(2014) Annet Kirabo et al.   JOURNAL OF CLINICAL INVESTIGATION

The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis

(2014) Juan Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

A Controlled Trial of Renal Denervation for Resistant Hypertension

(2014) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats

(2014) Xin-Ai Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Adipokines and insulin action

(2014) Alexander J Knights et al.   Adipocyte

Hypoadiponectinemia and aldosterone excess are associated with lack of blood pressure control in subjects with resistant hypertension

(2013) Ana PC de Faria et al.   HYPERTENSION RESEARCH

Infliximab, a TNF-α inhibitor, reduces 24-h ambulatory blood pressure in rheumatoid arthritis patients

(2013) S Yoshida et al.   JOURNAL OF HUMAN HYPERTENSION

Deregulation of adipokines related to target organ damage on resistant hypertension

(2013) A R Sabbatini et al.   JOURNAL OF HUMAN HYPERTENSION

Inhibition of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension

(2013) Srinivas Sriramula et al.   PLoS One

Adipokines Mediate Inflammation and Insulin Resistance

(2013) Hyokjoon Kwon et al.   Frontiers in Endocrinology

Infliximab prevents increased systolic blood pressure and upregulates the AKT/eNOS pathway in the aorta of spontaneously hypertensive rats

(2012) Ademir Gazzoto Filho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes

(2012) Arianna Carolina Rosa et al.   INFLAMMATION RESEARCH

High-circulating leptin levels are associated with increased blood pressure in uncontrolled resistant hypertension

(2012) C de Haro Moraes et al.   JOURNAL OF HUMAN HYPERTENSION

Vascular Actions of Aldosterone

(2012) Marie Briet et al.   JOURNAL OF VASCULAR RESEARCH

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage

(2011) Weiru Zhang et al.   HYPERTENSION

Anti-TNFα therapy may lead to blood pressure reductions through improved endothelium-dependent microvascular function in patients with rheumatoid arthritis

(2011) A Sandoo et al.   JOURNAL OF HUMAN HYPERTENSION

Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial

(2010) N. B. Klarenbeek et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

(2010) Marcia Venegas-Pont et al.   HYPERTENSION

The relationship between inflammation, obesity and risk for hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2010) S G Lakoski et al.   JOURNAL OF HUMAN HYPERTENSION

Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial

(2010)   LANCET

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

(2009) Henry Krum et al.   LANCET

Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats

(2009) Linda T. Tran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy

(2008) Srinivas Sriramula et al.   HYPERTENSION

TNFα antagonist upregulates interleukin-6 in rats with hypertensive heart failure

(2008) Espen Haugen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta

(2008) Stella Brili et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY