Aptamers: Novel Therapeutics and Potential Role in Neuro-Oncology

Targeting Ephrin Receptor Tyrosine kinase A2 with a selective aptamer for glioblastoma stem cells

(2020) Alessandra Affinito et al.   Molecular Therapy-Nucleic Acids

A comprehensive overview on the molecular biology of human glioma: what the clinician needs to know

(2020) P. D. Delgado-López et al.   Clinical & Translational Oncology

Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma

(2020) Michaël H. Meel et al.   CLINICAL CANCER RESEARCH

Combined Targeting of Glioblastoma Stem-Like Cells by Neutralizing RNA-Bio-Drugs for STAT3

(2020) Carla Lucia Esposito et al.   Cancers

Provision of rapid and specific ex vivo diagnosis of central nervous system lymphoma from rodent xenograft biopsies by a fluorescent aptamer

(2020) Joseph Georges et al.   JOURNAL OF NEUROSURGERY

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

(2020) Silvia Nuzzo et al.   Cancers

Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

(2019) Zachary Miklja et al.   NEURO-ONCOLOGY

Recent Advances in Aptamer Discovery and Applications

(2019) Yang Zhang et al.   MOLECULES

Phase I trial of convection-enhanced delivery of IL13-Pseudomonas toxin in children with diffuse intrinsic pontine glioma

(2019) John D. Heiss et al.   Journal of Neurosurgery-Pediatrics

An exploration of aptamer internalization mechanisms and their applications in drug delivery

(2019) Lin-Yan Wan et al.   Expert Opinion on Drug Delivery

Analyzing Secondary Structure Patterns in DNA Aptamers Identified via CompELS

(2019) Richard Sullivan et al.   MOLECULES

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

(2019) Maria C. Vladoiu et al.   NATURE

Future Considerations for Pediatric Cancer Survivorship: Translational Perspectives from Developmental Neuroscience

(2019) Rebecca M. Jones et al.   Developmental Cognitive Neuroscience

RNA aptamers targeting integrin α5β1 as probes for cyto- and histo-fluorescence in glioblastoma

(2019) P. Fechter et al.   Molecular Therapy-Nucleic Acids

Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma

(2019) Antonin Dréan et al.   JOURNAL OF NEURO-ONCOLOGY

Development of Novel antimiRzymes for Targeted Inhibition of miR-21 Expression in Solid Cancer Cells

(2019) Leon M. Larcher et al.   MOLECULES

Targeted and effective glioblastoma therapy via aptamer-modified tetrahedral framework nucleic acid-paclitaxel nanoconjugates that can pass the blood brain barrier

(2019) Sirong Shi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors

(2019) Silvia Triarico et al.   Cancers

Four steps for revealing and adjusting the 3D structure of aptamers in solution by small-angle X-ray scattering and computer simulation

(2019) Felix N. Tomilin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy

(2019) Tao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma

(2019) Wei Fu et al.   ACS Applied Materials & Interfaces

Therapeutic applications of AS1411 aptamer, an update review

(2019) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

(2019) Adachi et al.   MOLECULES

Molecularly Targeted Agents in the Therapy of Pediatric Brain Tumors

(2019) Miriam Bornhorst et al.   PEDIATRIC DRUGS

The Discovery of RNA Aptamers that Selectively Bind Glioblastoma Stem Cells

(2019) Alessandra Affinito et al.   Molecular Therapy-Nucleic Acids

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

(2018) Qiaoyi Wu et al.   ANALYST

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

(2018) Livia Garzia et al.   CELL

Classification of cancer cells using computational analysis of dynamic morphology

(2018) Mohammad R. Hasan et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

(2018) Saira Alli et al.   JOURNAL OF CONTROLLED RELEASE

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Aptamers in the Therapeutics and Diagnostics Pipelines

(2018) Harleen Kaur et al.   Theranostics

STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

(2018) Carla Lucia Esposito et al.   Molecular Therapy-Nucleic Acids

Aptamer Therapeutics in Cancer: Current and Future

(2018) Yoshihiro Morita et al.   Cancers

SELEX methods on the road to protein targeting with nucleic acid aptamers

(2018) Payam Bayat et al.   BIOCHIMIE

Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport

(2018) Cristina Díaz-Perlas et al.   Chemical Science

Competition-Enhanced Ligand Selection to Identify DNA Aptamers

(2018) Maeling J. N. Tapp et al.   ACS Combinatorial Science

Aptamer Based Targeted Drug Delivery Systems: Current Potential and Challenges

(2018) Fen He et al.   CURRENT MEDICINAL CHEMISTRY

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Associated Fibronectin Targeted Liposomal Nanoplatform for Cyclophilin A siRNA Delivery and Targeted Malignant Glioblastoma Therapy

(2018) Phei Er Saw et al.   Frontiers in Pharmacology

An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma

(2018) Sorah Yoon et al.   Molecular Therapy-Nucleic Acids

PET/MRI: Multiparametric imaging of brain tumors

(2017) Jiří Ferda et al.   EUROPEAN JOURNAL OF RADIOLOGY

Aptamer Bioinformatics

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications

(2017) Emma Hays et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aptamer-conjugated PEGylated quantum dots targeting epidermal growth factor receptor variant III for fluorescence imaging of glioma

(2017) Jiaze Tang et al.   International Journal of Nanomedicine

Precise glioblastoma targeting by AS1411 aptamer-functionalized poly ( l -γ-glutamylglutamine)–paclitaxel nanoconjugates

(2017) Zimiao Luo et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood–Brain Barrier

(2017) Ilaria Monaco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aptamers as Valuable Molecular Tools in Neurosciences

(2017) Olga Wolter et al.   JOURNAL OF NEUROSCIENCE

Aptamers as targeted therapeutics: current potential and challenges

(2017) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Assessment of Variability in the SOMAscan Assay

(2017) Julián Candia et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

(2016) Kristian W. Pajtler et al.   ACTA NEUROPATHOLOGICA

Morph-X-Select: Morphology-based tissue aptamer selection for ovarian cancer biomarker discovery

(2016) Hongyu Wang et al.   BIOTECHNIQUES

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

(2016) Carla L. Esposito et al.   JOURNAL OF CONTROLLED RELEASE

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

(2016) Carl Koschmann et al.   Science Translational Medicine

Identification of an Interfering Ligand Aptamer for EphB2/3 Receptors

(2016) Paola Amero et al.   Nucleic Acid Therapeutics

Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma

(2016) Carl Koschmann et al.   Oncotarget

Trends in aptamer selection methods and applications

(2015) Meral Yüce et al.   ANALYST

Current approaches in SELEX: An update to aptamer selection technology

(2015) Mariia Darmostuk et al.   BIOTECHNOLOGY ADVANCES

Hi-Fi SELEX: A high-fidelity digital-PCR based therapeutic aptamer discovery platform

(2015) Eric Ouellet et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

(2015) Florian Selt et al.   BRAIN PATHOLOGY

Aptamer for imaging and therapeutic targeting of brain tumor glioblastoma

(2015) Mateja Delač et al.   CYTOMETRY PART A

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

(2015) Tian-Yuan Fan et al.   International Journal of Nanomedicine

Notch Signaling Activation in Pediatric Low-Grade Astrocytoma

(2015) William D. Brandt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

EphB2 activation is required for ependymoma development as well as inhibits differentiation and promotes proliferation of the transformed cell

(2015) Phylip Chen et al.   Scientific Reports

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

(2015) Dongxi Xiang et al.   Theranostics

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma

(2015) Sherri Huang et al.   Cancers

Use of a Conformational Switching Aptamer for Rapid and Specific Ex Vivo Identification of Central Nervous System Lymphoma in a Xenograft Model

(2015) Joseph F. Georges et al.   PLoS One

Aptamer-based biosensors for biomedical diagnostics

(2014) Wenhu Zhou et al.   ANALYST

Nucleic Acid Aptamers: New Methods for Selection, Stabilization, and Application in Biomedical Science

(2014) Hoon Young Kong et al.   Biomolecules & Therapeutics

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

(2014) Carla L Esposito et al.   MOLECULAR THERAPY

Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment

(2014) C Reinemann et al.   SWISS MEDICAL WEEKLY

Histone H3 Mutations in Pediatric Brain Tumors

(2014) X. Liu et al.   Cold Spring Harbor Perspectives in Biology

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy

(2013) Xin Li et al.   JOURNAL OF CONTROLLED RELEASE

Recurrent H3.3 alterations in childhood tumors

(2013) Anders M Lindroth et al.   NATURE GENETICS

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

(2013) G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

(2013) Sarah Shigdar et al.   SENSORS

Advances in stem cell therapy against gliomas

(2013) M. Sarah S. Bovenberg et al.   TRENDS IN MOLECULAR MEDICINE

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles

(2012) Huile Gao et al.   BIOMATERIALS

Analysis of NADP+-dependent isocitrate dehydrogenase-1/2 gene mutations in pediatric brain tumors: report of a secondary anaplastic astrocytoma carrying the IDH1 mutation

(2012) Samantha Mascelli et al.   JOURNAL OF NEURO-ONCOLOGY

Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay

(2012) J. MÜLLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion

(2012) Arend H. Sikkema et al.   NEURO-ONCOLOGY

Biologically Targeted Therapeutics in Pediatric Brain Tumors

(2012) Amulya A. Nageswara Rao et al.   PEDIATRIC NEUROLOGY

Improving the Stability of Aptamers by Chemical Modification

(2011) R. E. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Antisense drug discovery and development

(2011) Tsuyoshi Yamamoto et al.   Future Medicinal Chemistry

Analysis of survival and prognostic factors of pediatric patients with brain tumor

(2011) Orlandira L. de Araujo et al.   Jornal de Pediatria

From SOMAmer-Based Biomarker Discovery to Diagnostic and Clinical Applications: A SOMAmer-Based, Streamlined Multiplex Proteomic Assay

(2011) Stephan Kraemer et al.   PLoS One

IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group

(2010) Ian F. Pollack et al.   CHILDS NERVOUS SYSTEM

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of an aptamer targeting hnRNP A1 by tissue slide‐based SELEX

(2009) Shaohua Li et al.   JOURNAL OF PATHOLOGY

Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation

(2009) Meltem Avci-Adali et al.   MOLECULES

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology