Recent Advances in Aptamer Discovery and Applications

In Vitro Selection of a DNA Aptamer by Cell-SELEX as a Molecular Probe for Cervical Cancer Recognition and Imaging

(2019) Jine Wang et al.   JOURNAL OF MOLECULAR EVOLUTION

Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco-2 cells

(2019) Yasen Maimaitiyiming et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells

(2018) Qiaoyi Wu et al.   ANALYST

Aptamer-mediated Plasmodium -specific diagnosis of malaria

(2018) Yee-Wai Cheung et al.   BIOCHIMIE

Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells

(2018) Laia Civit et al.   BIOCHIMIE

A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis

(2018) Lewis A. Fraser et al.   BIOSENSORS & BIOELECTRONICS

A highly sensitive impedimetric aptasensor for the selective detection of acetamiprid and atrazine based on microwires formed by platinum nanoparticles

(2018) L. Madianos et al.   BIOSENSORS & BIOELECTRONICS

Key Aspects of Nucleic Acid Library Design for in Vitro Selection

(2018) Maria Vorobyeva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Towards development of aptamers that specifically bind to lactate dehydrogenase of Plasmodium falciparum through epitopic targeting

(2018) Kelly-Anne Frith et al.   MALARIA JOURNAL

DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement

(2018) Junhua Mai et al.   MOLECULAR PHARMACEUTICS

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

(2018) Gerónimo Fernández et al.   MOLECULAR THERAPY

Practical Application of Aptamer-Based Biosensors in Detection of Low Molecular Weight Pollutants in Water Sources

(2018) et al.   MOLECULES

An aptamer-enabled DNA nanobox for protein sensing

(2018) Marco S.L. Tang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

(2018) Irina Randrianjatovo-Gbalou et al.   NUCLEIC ACIDS RESEARCH

Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice

(2018) Soizic Lecocq et al.   PLoS One

A regenerative and selective electrochemical aptasensor based on copper oxide nanoflowers-single walled carbon nanotubes nanocomposite for chlorpyrifos detection

(2018) Guoli Xu et al.   TALANTA

Selection of metastatic breast cancer cell-specific aptamers for the capture of CTCs with a metastatic phenotype by Cell-SELEX

(2018) Wan-Ming Li et al.   Molecular Therapy-Nucleic Acids

Therapeutic aptamers in discovery, preclinical and clinical stages

(2018) Said I. Ismail et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent developments in cell-SELEX technology for aptamer selection

(2018) Harleen Kaur   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SELEX methods on the road to protein targeting with nucleic acid aptamers

(2018) Payam Bayat et al.   BIOCHIMIE

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

(2018) Anirban Sinha et al.   BIOSENSORS & BIOELECTRONICS

Targeting the polyadenylation factor EhCFIm25 with RNA aptamers controls survival in Entamoeba histolytica

(2018) Juan David Ospina-Villa et al.   Scientific Reports

Phosphorothioate Modified AP613-1 Used for Hepatocellular Carcinoma Cell Imaging Via Specifically Targeting GPC3

(2018) Lili Dong et al.   Molecular Therapy-Nucleic Acids

Encoded particle microfluidic platform for rapid multiplexed screening and characterization of aptamers against influenza A nucleoprotein

(2018) Pelin Leblebici et al.   ANALYTICA CHIMICA ACTA

In vivo SELEX of bone targeting aptamer in prostate cancer bone metastasis model

(2018) Lingxiao Chen et al.   International Journal of Nanomedicine

Selection, Characterization, and Application of ssDNA Aptamer against Furaneol

(2018) Natalia Komarova et al.   MOLECULES

Advances on Aptamers against Protozoan Parasites

(2018) Juan Ospina-Villa et al.   Genes

In vitro selection of DNA aptamers recognizing drug-resistant ovarian cancer by cell-SELEX

(2018) Junqing He et al.   TALANTA

Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

(2017) Zhenjian Zhuo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo

(2017) Mona Alibolandi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Selection of aptamers based on a protein microarray integrated with a microfluidic chip

(2017) Xiaohui Liu et al.   LAB ON A CHIP

A single-stranded DNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression

(2017) Qin Pan et al.   MICROBIOLOGY AND IMMUNOLOGY

A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support

(2017) Xiangyan Wang et al.   MICROCHIMICA ACTA

Selection of DNA aptamers against penicillin G using Capture-SELEX for the development of an impedimetric sensor

(2017) Nathalie Paniel et al.   TALANTA

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

(2017) Jingying Zheng et al.   Theranostics

Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer

(2017) Yayu Wang et al.   Theranostics

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade

(2017) Dirk Zboralski et al.   Cancer Immunology Research

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

(2017) Bo-Tsang Huang et al.   Molecular Therapy-Nucleic Acids

The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression

(2017) Xinmeng Fan et al.   Molecular Therapy-Nucleic Acids

An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs

(2017) Gregory R. Wiedman et al.   mSphere

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

(2017) et al.   Cancers

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors

(2017) Iman Jeddi et al.   Scientific Reports

Ultrafine Graphene Nanomesh with Large On/Off Ratio for High-Performance Flexible Biosensors

(2016) Yanbing Yang et al.   ADVANCED FUNCTIONAL MATERIALS

Aptamers: versatile molecular recognition probes for cancer detection

(2016) Hongguang Sun et al.   ANALYST

Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells

(2016) Hasan E. Zumrut et al.   ANALYTICAL BIOCHEMISTRY

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies

(2016) Gerd Wallukat et al.   ATHEROSCLEROSIS

Fabricating a novel label-free aptasensor for acetamiprid by fluorescence resonance energy transfer between NH 2 -NaYF 4 : Yb, Ho@SiO 2 and Au nanoparticles

(2016) Weiwei Hu et al.   BIOSENSORS & BIOELECTRONICS

Label-free signal-on aptasensor for sensitive electrochemical detection of arsenite

(2016) Lin Cui et al.   BIOSENSORS & BIOELECTRONICS

Generation and characterization of quinolone-specific DNA aptamers suitable for water monitoring

(2016) C. Reinemann et al.   BIOSENSORS & BIOELECTRONICS

Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase

(2016) Priyamvada Jain et al.   MOLECULAR BIOTECHNOLOGY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Aptamers as radiopharmaceuticals for nuclear imaging and therapy

(2016) Marlies Gijs et al.   NUCLEAR MEDICINE AND BIOLOGY

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

(2016) Elisa Biondi et al.   NUCLEIC ACIDS RESEARCH

Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins

(2016) Hasan E. Zumrut et al.   Nucleic Acid Therapeutics

Identification of an aptamer through whole cell-SELEX for targeting high metastatic liver cancers

(2016) Yuan Rong et al.   Oncotarget

Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition

(2016) Sung-Jin Choi et al.   Scientific Reports

E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases

(2016) Yoshihiro Morita et al.   Molecular Therapy-Nucleic Acids

Targeting Insulin Receptor with a Novel Internalizing Aptamer

(2016) Margherita Iaboni et al.   Molecular Therapy-Nucleic Acids

Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14

(2016) Yuri Cho et al.   PLoS One

A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly

(2016) Maia Godonoga et al.   Scientific Reports

Acousto-microfluidics for screening of ssDNA aptamer

(2016) Jee-Woong Park et al.   Scientific Reports

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

Development of a fraction collection approach in capillary electrophoresis SELEX for aptamer selection

(2015) Zhaofeng Luo et al.   ANALYST

Evolution of DNA Aptamers through in Vitro Metastatic-Cell-Based Systematic Evolution of Ligands by Exponential Enrichment for Metastatic Cancer Recognition and Imaging

(2015) Xilan Li et al.   ANALYTICAL CHEMISTRY

Iodide-Responsive Cu–Au Nanoparticle-Based Colorimetric Platform for Ultrasensitive Detection of Target Cancer Cells

(2015) Xiaosheng Ye et al.   ANALYTICAL CHEMISTRY

Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters' fluorescence

(2015) Xiaoming Yang et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive and specific colorimetric detection of cancer cells via dual-aptamer target binding strategy

(2015) Kun Wang et al.   BIOSENSORS & BIOELECTRONICS

APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria

(2015) Roderick M. Dirkzwager et al.   CHEMICAL COMMUNICATIONS

Postoperative hemicrania continua-like headache - a case series

(2015) Andreas R Gantenbein et al.   JOURNAL OF HEADACHE AND PAIN

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Detection of Cryptosporidium parvum Oocysts on Fresh Produce Using DNA Aptamers

(2015) Asma Iqbal et al.   PLoS One

A Microfluidic Love-Wave Biosensing Device for PSA Detection Based on an Aptamer Beacon Probe

(2015) Feng Zhang et al.   SENSORS

More DNA–Aptamers for Small Drugs: A Capture–SELEX Coupled with Surface Plasmon Resonance and High-Throughput Sequencing

(2015) Fabio M. Spiga et al.   ACS Combinatorial Science

Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEX

(2015) Lili Dong et al.   Scientific Reports

DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition

(2015) Xiaoqiu Wu et al.   Theranostics

Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers

(2015) Aaron Prodeus et al.   Molecular Therapy-Nucleic Acids

Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP

(2015) Natalia Guerra-Pérez et al.   PLoS One

Aptamer-based biosensors for biomedical diagnostics

(2014) Wenhu Zhou et al.   ANALYST

An on-chip Cell-SELEX process for automatic selection of high-affinity aptamers specific to different histologically classified ovarian cancer cells

(2014) Lien-Yu Hung et al.   LAB ON A CHIP

Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX

(2014) Ji Won Kim et al.   MOLECULES AND CELLS

DNA Aptamer Evolved by Cell-SELEX for Recognition of Prostate Cancer

(2014) Yuanyuan Wang et al.   PLoS One

DNA-Aptamers Binding Aminoglycoside Antibiotics

(2014) Nadia Nikolaus et al.   SENSORS

DNA-Aptamer Targeting Vimentin for Tumor Therapy In Vivo

(2014) Tatyana N. Zamay et al.   Nucleic Acid Therapeutics

Aptamer Based, Non-PCR, Non-Serological Detection of Chagas Disease Biomarkers in Trypanosoma cruzi Infected Mice

(2014) Rana Nagarkatti et al.   PLoS Neglected Tropical Diseases

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

(2013) J. Hoellenriegel et al.   BLOOD

Directed polymerase evolution

(2013) Tingjian Chen et al.   FEBS LETTERS

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders

(2013) Chuang-Wei Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole Cell-SELEX Aptamers for Highly Specific Fluorescence Molecular Imaging of Carcinomas In Vivo

(2013) Hui Shi et al.   PLoS One

In vitro selection with artificial expanded genetic information systems

(2013) K. Sefah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Selection of Modified RNA Aptamers Against CD44 Cancer Stem Cell Marker

(2013) Nidaa Ababneh et al.   Nucleic Acid Therapeutics

Sol-Gel SELEX Circumventing Chemical Conjugation of Low Molecular Weight Metabolites Discovers Aptamers Selective to Xanthine

(2013) Hyunjung Bae et al.   Nucleic Acid Therapeutics

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Harnessing aptamers for electrochemical detection of endotoxin

(2012) Sung-Eun Kim et al.   ANALYTICAL BIOCHEMISTRY

Aptamer-Based Viability Impedimetric Sensor for Viruses

(2012) Mahmoud Labib et al.   ANALYTICAL CHEMISTRY

A highly selective electrochemical impedance spectroscopy-based aptasensor for sensitive detection of acetamiprid

(2012) Lifang Fan et al.   BIOSENSORS & BIOELECTRONICS

Selection and Identification of a DNA Aptamer Targeted to Vibrio parahemolyticus

(2012) Nuo Duan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Aptamer That Binds to the gD Protein of Herpes Simplex Virus 1 and Efficiently Inhibits Viral Entry

(2012) S. C. B. Gopinath et al.   JOURNAL OF VIROLOGY

UCLA1, a Synthetic Derivative of a gp120 RNA Aptamer, Inhibits Entry of Human Immunodeficiency Virus Type 1 Subtype C

(2012) H. T. Mufhandu et al.   JOURNAL OF VIROLOGY

Use of Cell-SELEX to Generate DNA Aptamers as Molecular Probes of HPV-Associated Cervical Cancer Cells

(2012) Jessica C. Graham et al.   PLoS One

Selection of RNA aptamers against mouse embryonic stem cells

(2011) Toshiro Iwagawa et al.   BIOCHIMIE

A Novel Aptamer Developed for Breast Cancer Cell Internalization

(2011) Kejing Zhang et al.   ChemMedChem

5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

(2011) Sun-Young Hwang et al.   NUCLEIC ACIDS RESEARCH

Development of Single-Stranded DNA Aptamers for Specific Bisphenol A Detection

(2011) Minjoung Jo et al.   OLIGONUCLEOTIDES

Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform

(2011) Kareem M. Ahmad et al.   PLoS One

Electrochemical aptasensor for detection of copper based on a reagentless signal-on architecture and amplification by gold nanoparticles

(2011) Zhengbo Chen et al.   TALANTA

Selection and characterization of DNA aptamers with binding selectivity to Campylobacter jejuni using whole-cell SELEX

(2010) Hari P. Dwivedi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Novel Screening Method for Competitive FRET-Aptamers Applied to E. coli Assay Development

(2010) John G. Bruno et al.   JOURNAL OF FLUORESCENCE

Reprogramming bacteria to seek and destroy an herbicide

(2010) Joy Sinha et al.   Nature Chemical Biology

Development of DNA aptamers using Cell-SELEX

(2010) Kwame Sefah et al.   Nature Protocols

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

(2010) M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free aptamer-based colorimetric detection of mercury ions in aqueous media using unmodified gold nanoparticles as colorimetric probe

(2009) Li Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Electrochemical aptasensor for tetracycline detection

(2009) Yoon-Jin Kim et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Arsenic Removal from Vietnamese Groundwater Using the Arsenic-Binding DNA Aptamer

(2009) Mina Kim et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses

(2009) Yi-Chung Chang et al.   FASEB JOURNAL

The molecular mechanisms of immunomodulation and tolerance induction to factor VIII

(2009) B. WATERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Selection of DNA aptamers using atomic force microscopy

(2009) Yusuke Miyachi et al.   NUCLEIC ACIDS RESEARCH

Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus

(2009) Xiaoxiao Cao et al.   NUCLEIC ACIDS RESEARCH

Micromagnetic selection of aptamers in microfluidic channels

(2009) X. Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection of Aptamers against Live Bacterial Cells

(2008) Camille L. A. Hamula et al.   ANALYTICAL CHEMISTRY

Determination of Ochratoxin A with a DNA Aptamer

(2008) Jorge A. Cruz-Aguado et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plastic-Adherent DNA Aptamer-Magnetic Bead and Quantum Dot Sandwich Assay for Campylobacter Detection

(2008) John G. Bruno et al.   JOURNAL OF FLUORESCENCE

Anti-Ccl2 Spiegelmer Permits 75% Dose Reduction of Cyclophosphamide to Control Diffuse Proliferative Lupus Nephritis and Pneumonitis in MRL-Fas(lpr) Mice

(2008) O. Kulkarni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase

(2007) Kyoung Jin Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS