Aptamer Therapeutics in Cancer: Current and Future

Application of aptamers in treatment and diagnosis of leukemia

(2017) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeting nucleolin for better survival in diffuse large B-cell lymphoma

(2017) N Jain et al.   LEUKEMIA

Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study

(2017) H Ludwig et al.   LEUKEMIA

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

(2017) Mizuki Nishino et al.   Nature Reviews Clinical Oncology

Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies

(2017) Enni-Kaisa Mustonen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

(2017) Jingying Zheng et al.   Theranostics

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade

(2017) Dirk Zboralski et al.   Cancer Immunology Research

Aptamer-based sandwich-type biosensors

(2017) Ho Bin Seo et al.   Journal of Biological Engineering

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

(2017) Bo-Tsang Huang et al.   Molecular Therapy-Nucleic Acids

The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression

(2017) Xinmeng Fan et al.   Molecular Therapy-Nucleic Acids

Aptamers in hematological malignancies and their potential therapeutic implications

(2016) Wanyan Ouyang et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies

(2016) Kyun Heo et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Next-generation polymer nanocomposite-based electrochemical sensors and biosensors: A review

(2016) Swati Shrivastava et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Fit for the Eye: Aptamers in Ocular Disorders

(2016) Daniel W. Drolet et al.   Nucleic Acid Therapeutics

Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

(2016) Erin E. Soule et al.   Nucleic Acid Therapeutics

Aptamers: A promising chemical antibody for cancer therapy

(2016) Gang Zhou et al.   Oncotarget

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

(2016) Mario Martínez Soldevilla et al.   Oncotarget

E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases

(2016) Yoshihiro Morita et al.   Molecular Therapy-Nucleic Acids

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

(2016) Wei-Yun Lai et al.   Molecular Therapy-Nucleic Acids

Modified Nucleoside Triphosphates for In-vitro Selection Techniques

(2016) María A. Dellafiore et al.   Frontiers in Chemistry

The roles of nucleolin subcellular localization in cancer

(2015) Caroline Madeleine Berger et al.   BIOCHIMIE

2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia

(2015) Mario Martinez Soldevilla et al.   BIOMATERIALS

Nucleic acid aptamers in cancer research, diagnosis and therapy

(2015) Haitao Ma et al.   CHEMICAL SOCIETY REVIEWS

Aptamers: Molecular Tools for Medical Diagnosis

(2015) Veli Ozalp et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Postoperative hemicrania continua-like headache - a case series

(2015) Andreas R Gantenbein et al.   JOURNAL OF HEADACHE AND PAIN

Blocking the Adhesion Cascade at the Premetastatic Niche for Prevention of Breast Cancer Metastasis

(2015) Shin-Ae Kang et al.   MOLECULAR THERAPY

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

(2015) Hsin-Yung Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice

(2015) Shin-Ae Kang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of TIM3 2’-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

(2015) Sandra Hervas-Stubbs et al.   Oncotarget

Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers

(2015) Aaron Prodeus et al.   Molecular Therapy-Nucleic Acids

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

(2015) Chang Ho Lee et al.   Molecular Therapy-Nucleic Acids

Reducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates

(2015) B Schrand et al.   OncoImmunology

4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity

(2015) Todd Bartkowiak et al.   Frontiers in Oncology

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting

(2015) Aman P. Mann et al.   Oncotarget

Selection of DNA aptamers against epidermal growth factor receptor with high affinity and specificity

(2014) Deng-Liang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NOX-A12: mobilizing CLL away from home

(2014) R. Marasca et al.   BLOOD

A DNA aptamer with high affinity and specificity for molecular recognition and targeting therapy of gastric cancer

(2014) Hong-Yong Cao et al.   BMC CANCER

Nucleic Acid Aptamer-Mediated Drug Delivery for Targeted Cancer Therapy

(2014) Huijie Zhu et al.   ChemMedChem

Molecular Pathways: HER3 Targeted Therapy

(2014) K. Gala et al.   CLINICAL CANCER RESEARCH

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer

(2014) Junhua Mai et al.   JOURNAL OF CONTROLLED RELEASE

DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice

(2014) Ayako Ojima et al.   LABORATORY INVESTIGATION

Targeted Inhibition of Prostate Cancer Metastases with an RNA Aptamer to Prostate-specific Membrane Antigen

(2014) Justin P Dassie et al.   MOLECULAR THERAPY

Cell Surface Nucleolin as a Target for Anti-Cancer Therapies

(2014) Marina Koutsioumpa et al.   Recent Patents on Anti-Cancer Drug Discovery

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

DNA-Aptamer Targeting Vimentin for Tumor Therapy In Vivo

(2014) Tatyana N. Zamay et al.   Nucleic Acid Therapeutics

Mechanism of Alternative Complement Pathway Dysregulation by a Phosphorothioate Oligonucleotide in Monkey and Human Serum

(2014) Scott P. Henry et al.   Nucleic Acid Therapeutics

SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy

(2014) Aldo M. Roccaro et al.   Cell Reports

Targeting 4-1BB Costimulation to the Tumor Stroma with Bispecific Aptamer Conjugates Enhances the Therapeutic Index of Tumor Immunotherapy

(2014) B. Schrand et al.   Cancer Immunology Research

A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

(2013) Gabriel J. Robbie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

(2013) J. Hoellenriegel et al.   BLOOD

Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12

(2013) A Vater et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A cell-based single-stranded DNA aptamer specifically targets gastric cancer

(2013) Xiaojiao Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

Periostin-binding DNA Aptamer Inhibits Breast Cancer Growth and Metastasis

(2013) Yu Jin Lee et al.   MOLECULAR THERAPY

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats

(2013) Shie-Chau Liu et al.   NEURO-ONCOLOGY

Investigating the Antiproliferative Activity of High Affinity DNA Aptamer on Cancer Cells

(2013) Harleen Kaur et al.   PLoS One

Potential Capacity of Aptamers to Trigger Immune Activation in Human Blood

(2013) Meltem Avci-Adali et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth

(2013) G. Mahlknecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD28 Aptamers as Powerful Immune Response Modulators

(2013) Fernando Pastor et al.   Molecular Therapy-Nucleic Acids

Toggled RNA Aptamers Against Aminoglycosides Allowing Facile Detection of Antibiotics Using Gold Nanoparticle Assays

(2012) Nicola Derbyshire et al.   ANALYTICAL CHEMISTRY

Inhibitory RNA aptamer against SP6 RNA polymerase

(2012) Yusuke Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proliferation and migration of tumor cells in tapered channels

(2012) Yuan Wan et al.   BIOMEDICAL MICRODEVICES

Aptamer-Mediated Blockade of IL4R  Triggers Apoptosis of MDSCs and Limits Tumor Progression

(2012) F. Roth et al.   CANCER RESEARCH

Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia

(2012) Evan A. Stein et al.   CIRCULATION

An RNA Aptamer That Binds Carcinoembryonic Antigen Inhibits Hepatic Metastasis of Colon Cancer Cells in Mice

(2012) Young Ju Lee et al.   GASTROENTEROLOGY

Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects)

(2012) Cordula Weber et al.   IMMUNOLOGY

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity

(2012) K. M. BOMPIANI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

(2012) Alexey Berezhnoy et al.   MOLECULAR THERAPY

Targeting Axl With an High-affinity Inhibitory Aptamer

(2012) Laura Cerchia et al.   MOLECULAR THERAPY

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

(2012) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Randomized, Placebo-Controlled Trial of Mipomersen in Patients with Severe Hypercholesterolemia Receiving Maximally Tolerated Lipid-Lowering Therapy

(2012) Mary P. McGowan et al.   PLoS One

Degradation of Nuclease-Stabilized RNA Oligonucleotides in Mycoplasma-Contaminated Cell Culture Media

(2012) Frank J. Hernandez et al.   Nucleic Acid Therapeutics

E-Selectin-Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow

(2011) Aman P. Mann et al.   ADVANCED MATERIALS

PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery

(2011) Paola Milla et al.   CURRENT DRUG METABOLISM

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

(2011) Na Li et al.   PLoS One

A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death

(2011) Carla Lucia Esposito et al.   PLoS One

Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells

(2011) Lindsay Jones Talbot et al.   SURGERY

In Vitro Selection of RNA Aptamer and Specific Targeting of ErbB2 in Breast Cancer Cells

(2011) Mee Young Kim et al.   Nucleic Acid Therapeutics

Discovery and Development of Therapeutic Aptamers

(2010) P.R. Bouchard et al.   Annual Review of Pharmacology and Toxicology

Engineering Dendritic Aptamer Assemblies as Superior Inhibitors of Protein Function

(2010) Youngmi Kim et al.   Chemistry-An Asian Journal

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

(2010) Fatima Akdim et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

(2010) Frederick J Raal et al.   LANCET

Molecular Evolution of Functional Nucleic Acids with Chemical Modifications

(2010) Masayasu Kuwahara et al.   MOLECULES

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Thioaptamer Ligand against E-Selectin: Potential Application for Inflamed Vasculature Targeting

(2010) Aman P. Mann et al.   PLoS One

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes

(2009) S. G. Sayyed et al.   DIABETOLOGIA

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A Hybrid DNA Aptamer-Dendrimer Nanomaterial for Targeted Cell Labeling

(2009) Jing Zhou et al.   MACROMOLECULAR BIOSCIENCE

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

(2009) S. Soundararajan et al.   MOLECULAR PHARMACOLOGY

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells

(2008) Zhiyong Mi et al.   MOLECULAR THERAPY

RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin

(2007) Jing Mi et al.   MOLECULAR THERAPY