The Role of Mitochondria in Drug-Induced Kidney Injury

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Metabolism in Acute Kidney Injury

(2020) Amanda J. Clark et al.   SEMINARS IN NEPHROLOGY

The footprints of mitochondrial impairment and cellular energy crisis in the pathogenesis of xenobiotics-induced nephrotoxicity, serum electrolytes imbalance, and Fanconi’s syndrome: A comprehensive review

(2019) Reza Heidari   TOXICOLOGY

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

(2019) Jiayin Han et al.   Frontiers in Pharmacology

Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

(2019) Molly O’Reilly et al.   Frontiers in Cellular Neuroscience

Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots

(2019) Sophia L Samodelov et al.   Nutrients

Mitochondrial transcription and translation: overview

(2018) Aaron R. D’Souza et al.   Essays in Biochemistry

Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems

(2018) Anna-Luisa Luger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells

(2017) Yuya Sakamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

The 6R’s of drug induced nephrotoxicity

(2017) Linda Awdishu et al.   BMC Nephrology

Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity

(2016) Zhibo Gai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences

(2016) Bruno C. Marreiros et al.   ENVIRONMENTAL MICROBIOLOGY

The Cell Killing Mechanisms of Hydroxyurea

(2016) Amanpreet Singh et al.   Genes

Preliminary Clinical Study of the Effect of Ascorbic Acid on Colistin-Associated Nephrotoxicity

(2015) Rujipas Sirijatuphat et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

(2015) Iliana A. Chatzispyrou et al.   CANCER RESEARCH

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

(2015) Eric A. J. Hoste et al.   INTENSIVE CARE MEDICINE

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

(2015) Xiaoxi Lu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity

(2015) Seoyeon Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)

(2015) Mahmoud M. Elguindy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phenotype standardization for drug-induced kidney disease

(2015) Ravindra L. Mehta et al.   KIDNEY INTERNATIONAL

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Antibacterial Mechanisms of Polymyxin and Bacterial Resistance

(2015) Zhiliang Yu et al.   Biomed Research International

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

(2015) Yong-Min Choi et al.   PLoS One

The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

(2014) Ana Cecilia Mesa-Arango et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals

(2014) František Trejtnar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

N-acetyl cysteine in prevention of amphotericin- induced electrolytes imbalances: a randomized, double-blinded, placebo-controlled, clinical trial

(2014) Iman Karimzadeh et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research

(2014) Pascale Fisel et al.   Expert Opinion on Drug Metabolism & Toxicology

Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats

(2014) Summya Rashid et al.   FOOD AND CHEMICAL TOXICOLOGY

Reactive oxygen species and redox compartmentalization

(2014) Nina Kaludercic et al.   Frontiers in Physiology

Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney

(2013) Hideyuki Motohashi et al.   AAPS Journal

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury

(2013) Paul M. Palevsky et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

(2013) Takahiro Suzuki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species

(2013) Miriam A. Moreira et al.   CLINICAL NUTRITION

New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues

(2013) Chongshan Dai et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

(2013) Zakuan Z Deris et al.   JOURNAL OF ANTIBIOTICS

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

(2013) S. Kalghatgi et al.   Science Translational Medicine

Immunocytochemistry for Vancomycin Using a Monoclonal Antibody That Reveals Accumulation of the Drug in Rat Kidney and Liver

(2012) Kunio Fujiwara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial superoxide production contributes to vancomycin-induced renal tubular cell apoptosis

(2012) Yohei Arimura et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Antifolates

(2012) Michele Visentin et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

(2011) Rongbao Zhao et al.   Annual Review of Nutrition

Acute Kidney Injury and Increasing Nephrotoxic-Medication Exposure in Noncritically-Ill Children

(2011) B. S. Moffett et al.   Clinical Journal of the American Society of Nephrology

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

(2011) J. M. Yousef et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I

(2011) Xiang Xue et al.   MOLECULAR PHARMACEUTICS

Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

(2011) Stephen J. Ralph et al.   PHARMACEUTICAL RESEARCH

Real-Time Monitoring of Cisplatin-Induced Cell Death

(2011) Hamed Alborzinia et al.   PLoS One

Conformational properties of cardiolipin-bound cytochrome c

(2011) J. Hanske et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Chronic kidney disease in patients with diabetes mellitus type 2 or hypertension in general practice

(2010) Victor van der Meer et al.   BRITISH JOURNAL OF GENERAL PRACTICE

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

(2010) Ana I. Morales et al.   KIDNEY INTERNATIONAL

OCT2 and MATE1 Provide Bidirectional Agmatine Transport

(2010) Tate N. Winter et al.   MOLECULAR PHARMACEUTICS

New Clues for Nephrotoxicity Induced by Ifosfamide: Preferential Renal Uptake via the Human Organic Cation Transporter 2

(2010) Giuliano Ciarimboli et al.   MOLECULAR PHARMACEUTICS

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Acute Taxol nephrotoxicity: Histological and ultrastructural studies of mice kidney parenchyma

(2010) Samar Omar Rabah   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Interaction of Aminoglycosides with Human Mitochondrial 12S rRNA Carrying the Deafness-Associated Mutation

(2009) Y. Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Polymyxin B Identified as an Inhibitor of Alternative NADH Dehydrogenase and Malate: Quinone Oxidoreductase from the Gram-positive Bacterium Mycobacterium smegmatis

(2009) T. Mogi et al.   JOURNAL OF BIOCHEMISTRY

Kidney amino acid transport

(2009) François Verrey et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy

(2009) Nadiya Bakhiya et al.   TOXICOLOGY

Targets of chloroacetaldehyde-induced nephrotoxicity

(2009) Burhan Knouzy et al.   TOXICOLOGY IN VITRO

Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels

(2008) Nuria Garrido et al.   BIOCHEMICAL JOURNAL

The ADP and ATP transport in mitochondria and its carrier

(2008) Martin Klingenberg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase

(2008) Jason D. Fowler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane

(2007) M. Huls et al.   KIDNEY INTERNATIONAL