The Cell Killing Mechanisms of Hydroxyurea

Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14 -Demethylase in the Ergosterol Biosynthesis Pathway

(2016) Y.-j. Xu et al.   GENETICS

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks

(2016) Chunshui Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks

(2016) Nicholas A. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

(2016) Christina M Zimanyi et al.   eLife

DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo

(2016) Meng-Er Huang et al.   Scientific Reports

Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor

(2015) Hei-Man Vincent Tang et al.   Scientific Reports

Widespread Natural Occurrence of Hydroxyurea in Animals

(2015) David I. Fraser et al.   PLoS One

Functional characterization of FgERG3 and FgERG5 associated with ergosterol biosynthesis, vegetative differentiation and virulence of Fusarium graminearum

(2014) Yingzi Yun et al.   FUNGAL GENETICS AND BIOLOGY

The Arabidopsis SIAMESE-RELATED Cyclin-Dependent Kinase Inhibitors SMR5 and SMR7 Regulate the DNA Damage Checkpoint in Response to Reactive Oxygen Species

(2014) D. Yi et al.   PLANT CELL

The Oxidative Stress Responsive Transcription Factor Pap1 Confers DNA Damage Resistance on Checkpoint-Deficient Fission Yeast Cells

(2014) Carrie Belfield et al.   PLoS One

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis

(2014) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiol-based H2O2 signalling in microbial systems

(2014) Susanna Boronat et al.   Redox Biology

Genome-Wide Screening with Hydroxyurea Reveals a Link between Nonessential Ribosomal Proteins and Reactive Oxygen Species Production

(2013) T. Nakayashiki et al.   JOURNAL OF BACTERIOLOGY

Investigating the Selectivity of Metalloenzyme Inhibitors

(2013) Joshua A. Day et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR

(2013) Brandon L. McKethan et al.   MOLECULAR MICROBIOLOGY

Chemical Suppression of Defects in Mitotic Spindle Assembly, Redox Control, and Sterol Biosynthesis by Hydroxyurea

(2013) Andrew McCulley et al.   G3-Genes Genomes Genetics

Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives

(2012) I-Ju Lee et al.   Cytoskeleton

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

(2012) J. J. Foti et al.   SCIENCE

Hydroxycarbamide: a user’s guide for chronic myeloproliferative disorders

(2011) Jerry L Spivak et al.   Expert Review of Anticancer Therapy

Investigation ofin VivoDiferric Tyrosyl Radical Formation inSaccharomyces cerevisiaeRnr2 Protein

(2011) Yan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Hydroxyurea suppresses HCV replication in humans: a Phase I trial of oral hydroxyurea in chronic hepatitis C patients

(2010) Akito Nozaki et al.   ANTIVIRAL THERAPY

Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms

(2010) K. Nestoras et al.   GENES & DEVELOPMENT

Thein VivoToxicity of Hydroxyurea Depends on Its Direct Target Catalase

(2010) Trine Juul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate

(2010) Soojin Jang et al.   MOLECULAR MICROBIOLOGY

Damage-induced phosphorylation of Sld3 is important to block late origin firing

(2010) Jaime Lopez-Mosqueda et al.   NATURE

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

(2010) Philip Zegerman et al.   NATURE

Global fitness profiling of fission yeast deletion strains by barcode sequencing

(2010) Tian Xu Han et al.   GENOME BIOLOGY

Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

(2009) Lijun Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast

(2009) Laurence Vernis et al.   PLoS One

Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding

(2009) Mark Bathe et al.   TRENDS IN MICROBIOLOGY

DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae

(2008) Lori A. Rowe et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma hydroxyurea determined by gas chromatography–mass spectrometry

(2008) Tayeb Kettani et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase

(2008) Yang David Lee et al.   MOLECULAR CELL