Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency

(2011) K. V. Salojin et al.   BLOOD

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption

(2010) Kris Mahadeo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Membrane Topological Analysis of the Proton-Coupled Folate Transporter (PCFT-SLC46A1) by the Substituted Cysteine Accessibility Method

(2010) Rongbao Zhao et al.   BIOCHEMISTRY

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

(2010) D. S. Shin et al.   BLOOD

The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1

(2010) Nitzan Gonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folate-Targeted Therapies for Cancer

(2010) Wei Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION

(2010) Berna Atabay et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse

(2010) Yoshiaki Kitamura et al.   PHARMACEUTICAL RESEARCH

Folate Receptor Alpha Defect Causes Cerebral Folate Transport Deficiency: A Treatable Neurodegenerative Disorder Associated with Disturbed Myelin Metabolism

(2009) Robert Steinfeld et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1

(2009) Ersin Selcuk Unal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

(2009) Simone Leuthold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs

(2009) Bradley L. Urquhart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hereditary folate malabsorption: A positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding

(2009) Inbal Lasry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional elements in the minimal promoter of the human proton-coupled folate transporter

(2009) Michal Stark et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter

(2009) Arturo Borzutzky et al.   CLINICAL IMMUNOLOGY

Pharmacogenetics of Drug Transporters

(2009) R. Franke et al.   CURRENT PHARMACEUTICAL DESIGN

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

(2009) Rongbao Zhao et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier

(2009) Zhanjun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Roles of the His247and His281Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1

(2009) Ersin Selcuk Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry†

(2009) Yijun Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal trancriptional regulatory region in an antifolate-resistant HeLa cell line

(2009) N. K. Diop-Bove et al.   MOLECULAR CANCER THERAPEUTICS

A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorption

(2009) Esther Meyer et al.   MOLECULAR GENETICS AND METABOLISM

Vitamin D3 and Its Nuclear Receptor Increase the Expression and Activity of the Human Proton-Coupled Folate Transporter

(2009) J. J. Eloranta et al.   MOLECULAR PHARMACOLOGY

CONGENITAL NULL MUTATIONS OF THE FOLR1 GENE: A PROGRESSIVE NEUROLOGIC DISEASE AND ITS TREATMENT

(2009) H. Cario et al.   NEUROLOGY

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model

(2008) Katsuhisa Inoue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

(2008) Nitzan Gonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)

(2008) Ersin Selcuk Unal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Mechanism of Carrier-Mediated Transport of Folates in BeWo Cells: The Involvement of Heme Carrier Protein 1 in Placental Folate Transport

(2008) Satoru YASUDA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function

(2008) I. Lasry et al.   BLOOD

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1)

(2008) Abas H. Laftah et al.   BRITISH JOURNAL OF NUTRITION

Oligomeric Structure of the Human Reduced Folate Carrier

(2008) Zhanjun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis

(2008) Rongbao Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Clinical Course and Genetic Defect in the PCFT Gene in a 27-Year-Old Woman with Hereditary Folate Malabsorption

(2008) Sang Hee Min et al.   JOURNAL OF PEDIATRICS

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)

(2008) Y. Kitamura et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Technical and biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations

(2008) M.M. Verbeek et al.   MOLECULAR GENETICS AND METABOLISM

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

(2008) R. Zhao et al.   MOLECULAR PHARMACOLOGY

Vitamin D deficiency: a global perspective

(2008) Ann Prentice   NUTRITION REVIEWS

Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia

(2007) Veedamali S. Subramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY