Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

(2020) Irune Diaz-Aparicio et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, Microglia, and the Immune System—How Are They Linked in Affective Disorders?

(2019) Carsten Culmsee et al.   Frontiers in Psychiatry

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Gene–environment interactions between HPA-axis genes and stressful life events in depression: a systematic review

(2019) Caroline Normann et al.   ACTA NEUROPSYCHIATRICA

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

(2019) Anthony S. Zannas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine Research in Depression: Principles, Challenges, and Open Questions

(2019) Hubertus Himmerich et al.   Frontiers in Psychiatry

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurogenesis and antidepressant action

(2019) Seon-Cheol Park   CELL AND TISSUE RESEARCH

Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium

(2019) Gara Arteaga-Henríquez et al.   Frontiers in Psychiatry

A methylation study of long-term depression risk

(2019) Shaunna L. Clark et al.   MOLECULAR PSYCHIATRY

Cell-Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder

(2019) Robin F. Chan et al.   BIOLOGICAL PSYCHIATRY

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

(2019) Yong U. Liu et al.   NATURE NEUROSCIENCE

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

(2019) Rianne D. Stowell et al.   NATURE NEUROSCIENCE

Abnormal Distribution and Function of Circulating Monocytes and Enhanced Bacterial Translocation in Major Depressive Disorder

(2019) Miguel Angel Alvarez-Mon et al.   Frontiers in Psychiatry

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

(2019) Chotima Böttcher et al.   Scientific Reports

Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies

(2019) Silvia Franchi et al.   Frontiers in Immunology

Opposite Molecular Signatures of Depression in Men and Women

(2018) Marianne L. Seney et al.   BIOLOGICAL PSYCHIATRY

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder

(2018) Gwenaël G.R. Leday et al.   BIOLOGICAL PSYCHIATRY

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

(2018) Wouter J. Peyrot et al.   BIOLOGICAL PSYCHIATRY

Postnatal maturation of microglia is associated with alternative activation and activated TGFβ signaling

(2018) Abdelraheim Attaai et al.   GLIA

Difference in proinflammatory cytokines produced by monocytes between patients with major depressive disorder and healthy controls

(2018) Hong-Xia Zhang et al.   JOURNAL OF AFFECTIVE DISORDERS

The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer’s Disease

(2018) Hua Ni et al.   JOURNAL OF ALZHEIMERS DISEASE

FoxO1, A2M, and TGF-β1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses

(2018) Annamaria Cattaneo et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Compensation of Signal Spillover in Suspension and Imaging Mass Cytometry

(2018) Stéphane Chevrier et al.   Cell Systems

Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder

(2018) Hua Li et al.   JOURNAL OF AFFECTIVE DISORDERS

Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response

(2018) Shariful A. Syed et al.   NEURON

Microglial activation occurs late during preclinical Alzheimer's disease

(2018) Wolfgang J. Streit et al.   GLIA

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

(2018) Isabel Barroeta-Espar et al.   NEUROBIOLOGY OF DISEASE

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders

(2017) Ralf Brisch et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Volatile Anesthetics and Immunity

(2017) Siavash Sedghi et al.   IMMUNOLOGICAL INVESTIGATIONS

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

(2017) Paula Kopschina Feltes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Inflammation and depression: a causal or coincidental link to the pathophysiology?

(2017) Brian E. Leonard   ACTA NEUROPSYCHIATRICA

Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

(2017) Frank Euteneuer et al.   Frontiers in Psychiatry

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

(2016) Sabine Hellwig et al.   BRAIN BEHAVIOR AND IMMUNITY

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

CD68/macrosialin: not just a histochemical marker

(2016) Dimitry A Chistiakov et al.   LABORATORY INVESTIGATION

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

(2015) Gérald J. Prud'homme et al.   AUTOIMMUNITY REVIEWS

Dissociation between sickness behavior and emotionality during lipopolysaccharide challenge in lymphocyte deficient Rag2−/− mice

(2015) Sarah M. Clark et al.   BEHAVIOURAL BRAIN RESEARCH

Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder

(2015) Laura Grosse et al.   BRAIN BEHAVIOR AND IMMUNITY

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder

(2014) L A Carvalho et al.   Translational Psychiatry

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis

(2011) Ruth Huizinga et al.   GLIA

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

(2010) Matthew D. Wilkerson et al.   BIOINFORMATICS

Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients

(2010) Roosmarijn C. Drexhage et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH