Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

CCR7 on CD4+T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis

(2018) Patrick Belikan et al.   JOURNAL OF IMMUNOLOGY

Compensation of Signal Spillover in Suspension and Imaging Mass Cytometry

(2018) Stéphane Chevrier et al.   Cell Systems

Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression

(2018) Antonio José Ruiz-Alcaraz et al.   Scientific Reports

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Genome-wide DNA methylation changes in CD19+ B cells from relapsing-remitting multiple sclerosis patients

(2018) Vicki E. Maltby et al.   Scientific Reports

Subsets of activated monocytes and markers of inflammation in incipient and progressed multiple sclerosis

(2017) Mikkel Carstensen Gjelstrup et al.   IMMUNOLOGY AND CELL BIOLOGY

Fingolimod additionally acts as immunomodulator focused on the innate immune system beyond its prominent effects on lymphocyte recirculation

(2017) Katja Thomas et al.   Journal of Neuroinflammation

CSF-1 regulates the function of monocytes in Crohn’s disease patients in remission

(2017) Juan Camilo Nieto et al.   Scientific Reports

Glatiramer acetate treatment normalized the monocyte activation profile in MS patients to that of healthy controls

(2016) Delgertsetseg Chuluundorj et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of Monocytes and Intestinal Macrophages in Crohnʼs Disease and Ulcerative Colitis

(2016) Susanne T. Gren et al.   INFLAMMATORY BOWEL DISEASES

Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study

(2016) Ludwig Rasche et al.   PLoS One

The Transition From First-Line to Second-Line Therapy in Multiple Sclerosis

(2015) Jan Dörr et al.   Current Treatment Options in Neurology

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Platinum-conjugated antibodies for application in mass cytometry

(2015) Henrik E. Mei et al.   CYTOMETRY PART A

Barcoding of Live Human Peripheral Blood Mononuclear Cells for Multiplexed Mass Cytometry

(2015) Henrik E. Mei et al.   JOURNAL OF IMMUNOLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Expansion and preferential activation of the CD14+ CD16+ monocyte subset during multiple sclerosis

(2014) Delgertsetseg Chuluundorj et al.   IMMUNOLOGY AND CELL BIOLOGY

Is T-bet a Potential Therapeutic Target in Multiple Sclerosis?

(2014) Michael K. Racke et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Immune-mediated disease genetics: the shared basis of pathogenesis

(2012) Chris Cotsapas et al.   TRENDS IN IMMUNOLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Treatment of multiple sclerosis: current concepts and future perspectives

(2011) Dorothea Buck et al.   JOURNAL OF NEUROLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

The CD14+/lowCD16+ monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14+CD16− subset

(2011) C Zhao et al.   Cell Death & Disease

NFAT pulls the strings during CD4+ T helper cell effector functions

(2010) N. Hermann-Kleiter et al.   BLOOD

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

TLR-Mediated Loss of CD62L Focuses B Cell Traffic to the Spleen during Salmonella typhimurium Infection

(2010) V. L. Morrison et al.   JOURNAL OF IMMUNOLOGY

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN