Flavonoids from Aurantii Fructus Immaturus and Aurantii Fructus: promising phytomedicines for the treatment of liver diseases

Naringenin: a potential natural remedy against methotrexate-induced hepatotoxicity in rats

(2020) Alireza Malayeri et al.   DRUG AND CHEMICAL TOXICOLOGY

Single or combined protective and therapeutic impact of taurine and hesperidin on carbon tetrachloride-induced acute hepatic injury in rat

(2020) Yasmina M. Abd-Elhakim et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Correction to 6-C-(E-Phenylethenyl)Naringenin Attenuates the Stemness of Hepatocellular Carcinoma Cells by Suppressing Wnt/β-Catenin Signaling

(2020) Qingzheng Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell

(2020) Rasha Al-Rikabi et al.   MOLECULES

Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression

(2020) Jingyuan Wan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes

(2020) Mengmeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

(2020) Ying‐Jie He et al.   JOURNAL OF SEPARATION SCIENCE

The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

(2019) Osama M. Ahmed et al.   Oxidative Medicine and Cellular Longevity

Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats

(2019) Yomna S. Mo’men et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis

(2019) Theodomir Dusabimana et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hesperidin‐CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells

(2019) Huma Naz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

4-Methylcoumarin-[5,6–g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation

(2019) Hong-Wu Meng et al.   TOXICOLOGY

Tangeretin inhibits hepatocellular carcinoma proliferation and migration by promoting autophagy-related BECLIN1

(2019) Jiao Zheng et al.   Cancer Management and Research

Hesperidin suppressed hepatic precancerous lesions via modulation of exophagy in rats

(2019) Amany H. Hasanin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice

(2019) Ruqayya Afridi et al.   BMC Pharmacology & Toxicology

Naringenin attenuates nonalocholic fatty liver disease by downregulating NLRP3/NF‐κB pathway in mice

(2019) Qinyu Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

(2019) Osama M. Ahmed et al.   DRUG AND CHEMICAL TOXICOLOGY

Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats

(2019) Abdelazim E. Elhelaly et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

6-C-(E-Phenylethenyl)Naringenin Attenuates the Stemness of Hepatocellular Carcinoma Cells by Suppressing Wnt/β-Catenin Signaling

(2019) Qingzheng Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats

(2019) Mehmet Güvenç et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

(2019) Sen Li et al.   Nutrition & Diabetes

The flavonoid-rich Quzhou Fructus Aurantii extract modulates gut microbiota and prevents obesity in high-fat diet-fed mice

(2019) Yong-feng Bai et al.   Nutrition & Diabetes

Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats

(2019) Yasin Duran et al.   BIOTECHNIC & HISTOCHEMISTRY

Chinese herbal medicine therapy and the risk of overall mortality for patients with liver cancer who underwent surgical resection in Taiwan

(2019) Fuu-Jen Tsai et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways

(2019) Erika Hernández-Aquino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A systematic review of the effectiveness and safety of Chinese herbal medicine formula Gualou Xiebai Banxia (GLXBBX) decoction for the treatment of stable angina pectoris

(2019) Mingtai Chen et al.   MEDICINE

Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism

(2019) Rinkiko Suguro et al.   PHARMACOLOGICAL RESEARCH

Bile acid profiles within the enterohepatic circulation in a diabetic rat model after bariatric surgeries

(2018) Meng Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes

(2018) Guoyuan Qi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Naringin attenuates liver damage in streptozotocin-induced diabetic rats

(2018) Valeria Rodríguez et al.   BIOMEDICINE & PHARMACOTHERAPY

Heated naringin mitigate the genotoxicity effect of Mitomycin C in BALB/c mice through enhancing the antioxidant status

(2018) Mouna Maatouk et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative Stress and Cancer: The Role of Nrf2

(2018) Soraya Sajadimajd et al.   CURRENT CANCER DRUG TARGETS

PPARγ-targeting potential for radioprotection

(2018) Simran Kaur et al.   CURRENT DRUG TARGETS

Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway

(2018) R. Kong et al.   CURRENT MOLECULAR MEDICINE

Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage

(2018) Cuneyt Caglayan et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Attenuation of tert-Butyl Hydroperoxide (t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2–ARE and MAPK Signaling Pathways

(2018) Fuqiang Liang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role and mechanisms of autophagy in acetaminophen-induced liver injury

(2018) Xiaojuan Chao et al.   LIVER INTERNATIONAL

Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence

(2018) Ahmed H. El-desoky et al.   PHYTOMEDICINE

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

(2018) Erika Hernández-Aquino et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Role of Quzhou Fructus Aurantii Extract in Preventing and Treating Acute Lung Injury and Inflammation

(2018) Lili Li et al.   Scientific Reports

Anti-inflammatory effects of Zhishi and Zhiqiao revealed by network pharmacology integrated with molecular mechanism and metabolomics studies

(2018) Siyu Zhao et al.   PHYTOMEDICINE

Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-κB in mice

(2018) Zehui Lv et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prevention of rat liver fibrosis by selective targeting of hepatic stellate cells using hesperidin carriers

(2018) Mohamed A. Morsy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects of dietary supplementation with essential oils and organic acids on the growth performance, immune system, fecal volatile fatty acids, and microflora community in weaned piglets

(2018) Caimei Yang et al.   JOURNAL OF ANIMAL SCIENCE

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

(2018) Ruthvika Joshi et al.   LIFE SCIENCES

Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress

(2018) Sabah Ansar et al.   BMC Pharmacology & Toxicology

Anti-atherosclerotic effect of hesperidin in LDLr −/− mice and its possible mechanism

(2017) Ye-Zi Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HNE as an inducer of COX-2

(2017) Koji Uchida   FREE RADICAL BIOLOGY AND MEDICINE

Emerging roles of SIRT1 in fatty liver diseases

(2017) Ren-Bo Ding et al.   International Journal of Biological Sciences

Differentiation between Flavors of Sweet Orange (Citrus sinensis) and Mandarin (Citrus reticulata)

(2017) Shi Feng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Naringin abates adverse effects of cadmium-mediated hepatotoxicity: An experimental study using HepG2 cells

(2017) Visesh Kumar Rathi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways

(2017) Randa A. Zaghloul et al.   LIFE SCIENCES

Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K/Akt pathway

(2017) Kholoud Alaa El-Mihi et al.   LIFE SCIENCES

Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices

(2017) Zahira Fernández-Bedmar et al.   MOLECULAR CARCINOGENESIS

Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity

(2017) Young-Je Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Eriodictyol, Not Its Glucuronide Metabolites, Attenuates Acetaminophen-Induced Hepatotoxicity

(2017) Zhaoyu Wang et al.   MOLECULAR PHARMACEUTICS

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae

(2017) Haiyan Lin et al.   ONCOLOGY REPORTS

The emerging role of AMP-activated protein kinase in cholestatic liver diseases

(2017) Xiaojiaoyang Li et al.   PHARMACOLOGICAL RESEARCH

Citrus aurantium (bitter orange) extract: Safety assessment by acute and 14-day oral toxicity studies in rats and the Ames Test for mutagenicity

(2017) N.S. Deshmukh et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway

(2017) Wan-xia Li et al.   TOXICOLOGY

Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl 4 -induced acute liver injury and LPS-treated RAW264.7 cells

(2017) Xin Chen et al.   TOXICOLOGY LETTERS

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

(2017) Erika Hernández-Aquino et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2

(2017) Guanghong Xie et al.   Oncotarget

Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor

(2017) Naoto Okada et al.   Frontiers in Pharmacology

Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats

(2016) Aslı Çetin et al.   Archives of Medical Science

Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats

(2016) Soha M. Hamdy et al.   BIOMEDICINE & PHARMACOTHERAPY

Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin

(2016) Hongbo Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparison of Aurantii Fructus Immaturus and Aurantii Fructus based on multiple chromatographic analysis and chemometrics methods

(2016) Pei Li et al.   JOURNAL OF CHROMATOGRAPHY A

Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

(2016) Zhenxing He et al.   Molecular Medicine Reports

Chemistry and Pharmacology of Citrus sinensis

(2016) Juan Favela-Hernández et al.   MOLECULES

Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1

(2016) Mohammad Adil et al.   RENAL FAILURE

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis

(2016) Hany A. Omar et al.   PLoS One

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Health-promoting effects of the citrus flavanone hesperidin

(2015) Chaoyun Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway

(2015) Yassine Chtourou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice

(2015) Qiong Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

(2015) Kívia de Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation

(2015) Chuanyang Su et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α

(2015) Mohammad Adil et al.   RENAL FAILURE

Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

(2015) Ratana Banjerdpongchai et al.   TUMOR BIOLOGY

Naringin prevents carbon tetrachloride-induced acute liver injury in mice

(2015) Deshi Dong et al.   Journal of Functional Foods

Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

(2015) GUANG-FA ZHU et al.   Experimental and Therapeutic Medicine

Liver fibrosis: Common mechanisms and antifibrotic therapies

(2015) Detlef Schuppan   Clinics and Research in Hepatology and Gastroenterology

Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation

(2014) Ayman M. Mahmoud   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro

(2014) Lihua Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Naringenin attenuates CCl4-induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats

(2014) Mohammad Ali Esmaeili et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Protective effects of hesperidin on concanavalin A-induced hepatic injury in mice

(2014) Gang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Characterization and classification of seven Citrus herbs by liquid chromatography–quadrupole time-of-flight mass spectrometry and genetic algorithm optimized support vector machines

(2014) Li Duan et al.   JOURNAL OF CHROMATOGRAPHY A

Antioxidant and Hepatoprotective Effects of Naringenin and Its β-Cyclodextrin Formulation in Mice Intoxicated with Carbon Tetrachloride: A Comparative Study

(2014) Anca Hermenean et al.   JOURNAL OF MEDICINAL FOOD

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats

(2014) Shimaa M. Elshazly et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hesperidin Prevents Liver Fibrosis in Rats by Decreasing the Expression of Nuclear Factor-κB, Transforming Growth Factor-� and Connective Tissue Growth Factor

(2014) J. Eliuth Pérez-Vargas et al.   PHARMACOLOGY

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

A Combination of Glucosyl Hesperidin and Caffeine Exhibits an Anti-obesity Effect by Inhibition of Hepatic Lipogenesis in Mice

(2014) Tatsuya Ohara et al.   PHYTOTHERAPY RESEARCH

Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes

(2013) Emi Yoshigai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice

(2013) Ho-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

(2013) Floriane Pez et al.   JOURNAL OF HEPATOLOGY

Naringenin (Citrus Flavonone) Induces Growth Inhibition, Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinoma Cells

(2013) Duraikannu Arul et al.   PATHOLOGY & ONCOLOGY RESEARCH

Anti-inflammatory role of naringenin in rats with ethanol induced liver injury

(2012) Jayachitra Jayaraman et al.   TOXICOLOGY MECHANISMS AND METHODS

Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice

(2012) Yingjian Lv et al.   Food & Function

Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet

(2011) Peng Pu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats

(2011) Véronique Leray et al.   BRITISH JOURNAL OF NUTRITION

Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro

(2011) Ganesh Chandra Jagetia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats

(2011) Xinhui Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats

(2010) Anshu Jain et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes

(2010) Mingcang Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringenin modulates circulatory lipid peroxidation, anti-oxidant status and hepatic alcohol metabolizing enzymes in rats with ethanol induced liver injury

(2010) Jayachitra Jayaraman et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Chemical Synthesis of Citrus Flavanone Glucuronides

(2010) Muhammad Kamran Khan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hesperidin Gastroresistant Microparticles by Spray-Drying: Preparation, Characterization, and Dissolution Profiles

(2009) Francesca Sansone et al.   AAPS PHARMSCITECH

Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin

(2009) J. Renugadevi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity

(2008) O. Benavente-García et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)

(2008) Qingying Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor

(2008) Emma M. Allister et al.   JOURNAL OF LIPID RESEARCH