Review
Oncology
Rainbow Wing Hei Leung, Terence Kin Wah Lee
Summary: Aberrant regulation of Wnt/β-catenin signaling plays a significant role in hepatocellular carcinoma (HCC) development and progression, and is associated with metabolic reprogramming, cancer stemness, and drug resistance. This review summarizes the regulatory mechanism and role of Wnt/β-catenin signaling in HCC, and provides an update on targeting this signaling pathway for effective cancer therapy.
Article
Oncology
Jing Zhang, Pengfei Li, Ting Li, Zhiqin Zhou, Huiling Wu, Lei Zhang
Summary: The study reveals that CORO6 is highly expressed in HCC samples with higher grades and correlates with poor patient outcomes. Depletion of CORO6 significantly impairs the cell survival, migratory, and invasive abilities of HCC cells, and enhances Wnt signaling in these cells.
Article
Agriculture, Multidisciplinary
Qian Zhou, Hui Xu, Yueliang Zhao, Bin Liu, Ka-Wing Cheng, Feng Chen, Mingfu Wang
Summary: The study found that the styryl flavonoid 6-PN could inhibit the generation of pro-inflammatory cytokines and reactive oxygen species (ROS) by downregulating the protein levels of AGE receptor (RAGE) and NADPH oxidase, improving the damage caused by AGE to cells. Compared to its parental compound, 6-PN showed higher bioavailability. Additionally, 6-PN inhibited AGE-induced inflammation through the activation of the Nrf2 signaling pathway, and this anti-inflammatory effect was blocked by the Nrf2 inhibitor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Cell Biology
Shi Wei, Miaomiao Dai, Chi Zhang, Kai Teng, Fengwei Wang, Hongbo Li, Weipeng Sun, Zihao Feng, Tiebang Kang, Xinyuan Guan, Ruihua Xu, Muyan Cai, Dan Xie
Summary: This study showed that KIF2C is significantly upregulated in HCC and associated with poor prognosis. Functional assays revealed that KIF2C promotes HCC cell proliferation, migration, invasion, and metastasis. Mechanistically, the study identified TBC1D7 as a binding partner of KIF2C, disrupting TSC complex formation and enhancing mTORC1 signaling.
Review
Oncology
Stefan Koch
Summary: This article discusses the control of the Wnt pathway by FOX proteins, and the contribution of their interaction to cancer initiation and progression. Further research on FOX biology may lead to new targeted treatments for cancer.
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Urology & Nephrology
Xiaowen Chen, Huishi Tan, Jie Xu, Yuan Tian, Qian Yuan, Yangyang Zuo, Qiyan Chen, Xue Hong, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu
Summary: The Klotho-derived peptide KP6 mimics the protective effects of Klotho in diabetic kidney disease, alleviating established proteinuria, glomerular hypertrophy, podocyte damage, glomerulosclerosis, and interstitial fibrotic lesions by blocking the Wnt/beta-catenin signaling pathway.
KIDNEY INTERNATIONAL
(2022)
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Integrative & Complementary Medicine
Yi Zhang, Jingjing Wang, Yong Qu, Yunzhong Chen
Summary: The study showed that 6-Shogaol inhibits the progression of liver cancer by mediating the Wnt/beta-catenin signaling pathway. The expression of TLR4 and FOXO3a in liver cancer cells is influenced by 6-Shogaol treatment, and 6-Shogaol can reverse their expression.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Food Science & Technology
Jie-Hua Chen, Louise Weiwei Lu, Qian Ge, Dana Feng, Jianfeng Yu, Bin Liu, Ruijie Zhang, Xinying Zhang, Caiqun Ouyang, Feng Chen
Summary: The use of time restricted eating (TRE) for weight management and metabolic health in overweight and obese individuals is still a topic of debate. This meta-analysis found that TRE can lead to significant weight loss, but mainly through the loss of lean mass rather than fat mass. TRE was also observed to have positive effects on blood pressure, insulin levels, and glucose metabolism. However, it did not have a significant impact on lipid profiles. Caution should be exercised when administering TRE to overweight and obese individuals with comorbidities.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Engineering, Environmental
Zhenyu Fan, Li Wang, Qingqing Jiang, Daming Fan, Jianbo Xiao, Mingfu Wang, Yueliang Zhao
Summary: Home cooking oil fumes contain toxic chemicals, including aldehydes. Adding docosahexaenoic acid (DHA) to oils increases aldehyde emissions. However, adding the flavonoid quercetin significantly reduces aldehyde emissions from DHA-fortified oils and protects unsaturated fatty acids (UFAs) from oxidation. Quercetin can be used as a natural additive to reduce aldehyde emissions, indoor air pollution, and preserve functional DHA and UFAs in cooking oils.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Medicinal
Han Sun, Yuxin Wang, Yongjin He, Bin Liu, Haijin Mou, Feng Chen, Shufang Yang
Summary: In the food industry, there is a growing focus on natural pigments instead of synthetic ones due to their excellent coloring ability and health properties. Microalgae are recognized as major sources of naturally derived commercial pigments and have gained significant value in the global food pigment market. This review provides updated information on the characteristics, application fields, production stability, and extraction processes of microalgae-derived pigments, particularly chlorophylls, carotenoids, and phycobiliproteins. The potential uses of these pigments as eco-friendly colorants, nutraceuticals, and antioxidants in food products are discussed, along with cultivation strategies and technical challenges in downstream processing.
Article
Food Science & Technology
Yuanyuan Hu, Zhengqi Liu, Xiaoya Tao, Jinjin Li, Zuoxu Hou, Xiaoming Guo, Dayong Zhou, Mingfu Wang, Beiwei Zhu
Summary: This study investigated the toxic effects of tt-DDE exposure on human umbilical vein endothelial cells (HUVECs) and the potential protective effects of green tea catechins. The results showed that tt-DDE exposure induced pyroptosis and NLRP3 inflammasome activation in endothelial cells, while green tea catechins, particularly epigallocatechin-3-gallate (EGCG), effectively alleviated tt-DDE-induced cytotoxicity and dysfunction. These findings provide new insights into tt-DDE-induced endothelial injury and demonstrate the protective role of EGCG against tt-DDE-associated endothelial toxicity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Engineering, Environmental
Lexin Long, Yao Xiao, Jordy Evan Sulaiman, Fuqing Luo, Jian-Wei Tang, Yuqing Huang, Chuanhai Wu, Long Wu, Waichuen Wong, Feng Chen, Henry Lam, Pei-Yuan Qian
Summary: This study demonstrates that Elasnin could be effective in preventing marine biofilms and biofouling as a signaling molecule. It highlights the importance of finding environmentally friendly antibiofilm compounds to control marine biofilms, which pose significant threats to public health and the maritime industry. Elasnin acts by promoting the growth of dominant species while disrupting their regulation of the ATP-binding cassette transport system and the bacterial secretion system, ultimately inhibiting biofilm maturation and biofouler settlement. This study provides valuable insights into the mode of action of Elasnin and its application potential in eco-friendly technologies.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Asad Nawaz, Baoping Shi, Sana Irshad, Hao Suo, Xia Wang, Yuge Bi, Mingfu Wang, Feng Chen, Ka -Wing Cheng
Summary: The present study investigated the effects of five emulsifiers on the formation of harmful substances in chemical models and roasted chicken patties. DMG and SPP were found to be the most promising, effectively reducing the contents of these substances in the patties. This inhibitory effect was partially mediated through the retention of water in the muscle tissue, as revealed by magnetic resonance imaging analysis. The findings suggest that SPP and DMG are effective additives for reducing the formation of harmful substances in meat-based products.
Article
Agriculture, Multidisciplinary
Hao Suo, Mohammad Rezaul Islam Shishir, Qi Wang, Mingfu Wang, Feng Chen, Ka Wing Cheng
Summary: This study found that red wine high-molecular-weight polyphenolic complexes (HPPCs) can inhibit key metabolic syndrome-associated enzymes and modulate human gut microbiota (GM) in vitro. Supplementation of HPPCs effectively attenuated high-fat diet-induced metabolic disturbance in mice, including obesity, insulin resistance, and dysregulation of lipid and glucose metabolism. It also improved the abundance of certain bacteria and the production of short-chain fatty acids, while modulating vitamin B metabolism-associated pathways. The findings suggest that dietary supplementation with red wine HPPCs may be a promising strategy for managing weight gain and metabolic dysregulation associated with high-fat diet.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Zahra Batool, Jie-Hua Chen, Bin Liu, Feng Chen, Mingfu Wang
Summary: A wide range of food processing contaminants (FPCs) are formed during the thermal processing of food products, with furan being highly volatile and present in various thermally processed foods. Therefore, it is necessary to identify the reasons for furan occurrence in different foods, determine the main sources of furan exposure, investigate factors affecting its formation, and develop specific analytical methods for its detection to guide future research. Controlling furan formation in processed foods at a large scale is challenging, and ongoing research is focused on this issue. Furthermore, understanding the molecular-level adverse effects of furan on human health is crucial for accurate risk assessment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
Yuting Su, Qian Zhou, Hui Xu, Manting Huang, Siqian Li, Jiayi He, Ka-Wing Cheng, Mingfu Wang
Summary: By developing the CM-Cur/QT complex, the solubility and stability of quercetin were improved, leading to enhanced bioavailability. The complex showed increased bio-accessibility and antioxidant efficacy during in vitro digestion, and facilitated the internalization of quercetin in macrophages, exerting a potential synergistic anti-inflammatory effect.
FOOD HYDROCOLLOIDS
(2024)
Article
Agriculture, Multidisciplinary
Linghui Kong, Xinyi Fan, Limin Guo, Qingqing Jiang, Jianbo Xiao, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: This study examined the inhibitory effects of three soybean isoflavones and two soybean phytosterols on the formation of 3-chloropropane-1,2-diol fatty acid esters (3-MCPDE) and aldehydes in heated soybean oil. It was found that stigmasterol significantly reduced the formation of 3-MCPDE and aldehydes by reacting with glycidyl esters (GEs) and glycidol, and protecting fatty acids from oxidation. The content of stigmasterol in soybean oil decreased with prolonged heating time and the migration of stigmasterol from soybean oil to fried dough sticks decreased with repeated frying sessions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Qian Zhou, Wenxin Liang, Jiaqian Wan, Mingfu Wang
Summary: In this study, the antiglycative capabilities of some popular microgreens were investigated in chemical and real food models. Baby spinach showed the highest antiglycative activity, mainly through antioxidation, and its fortification in bread significantly inhibited AGEs formation without affecting taste and food quality. Antiglycative components were tentatively identified as chlorophyll derivatives mainly distributed in leaves. This study highlights the potential of baby spinach as a healthy functional food with antiglycative benefits.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
