Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco

Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides

(2013) Krystal Teasley Hamorsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design

(2013) Weizao Chen et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

HIV trial under scrutiny

(2013) Meredith Wadman   NATURE

Prevention measures

(2013)   NATURE MEDICINE

Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

(2013) Alexandra Castilho et al.   PLoS One

Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems

(2013) Yvonne Rosenberg et al.   PLoS One

The Antibody Response against HIV-1

(2013) J. Overbaugh et al.   Cold Spring Harbor Perspectives in Medicine

Microbicides: Topical Prevention against HIV

(2013) R. J. Shattock et al.   Cold Spring Harbor Perspectives in Medicine

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Glyco-engineering in plants to produce human-like N-glycan structures

(2012) Alexandra Castilho et al.   Biotechnology Journal

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model

(2012) Milena Veselinovic et al.   VIROLOGY

Combinatorial Approaches to the Prevention and Treatment of HIV-1 Infection

(2011) Vanessa Pirrone et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Antibody degradation in tobacco plants: a predominantly apoplastic process

(2011) Verena K Hehle et al.   BMC BIOTECHNOLOGY

Life expectancy of HIV-positive adults: a review

(2011) Margaret T. May et al.   Sexual Health

Production of heterologous proteins in plants: Strategies for optimal expression

(2010) Priti N Desai et al.   BIOTECHNOLOGY ADVANCES

Fc-Glycosylation Influences Fc  Receptor Binding and Cell-Mediated Anti-HIV Activity of Monoclonal Antibody 2G12

(2010) D. N. Forthal et al.   JOURNAL OF IMMUNOLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

(2010) Frank Sainsbury et al.   PLoS One

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables

(2009) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

(2009) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants

(2009) Frank Sainsbury et al.   PLANT BIOTECHNOLOGY JOURNAL

Optimisation of contained Nicotiana tabacum cultivation for the production of recombinant protein pharmaceuticals

(2009) Richard Colgan et al.   TRANSGENIC RESEARCH

Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals

(2008) Y. Li et al.   JOURNAL OF VIROLOGY

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Extremely High-Level and Rapid Transient Protein Production in Plants without the Use of Viral Replication

(2008) F. Sainsbury et al.   PLANT PHYSIOLOGY