Recent Progress in the Development of New Antimalarial Drugs with Novel Targets

Preclinical Antimalarial Combination Studies: The Case of M5717, a P. falciparum Elongation Factor 2 Inhibitor and Pyronaridine, a Hemozoin Formation Inhibitor

(2020) Matthias Rottmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tafenoquine: A Step toward Malaria Elimination

(2020) Kuan-Yi Lu et al.   BIOCHEMISTRY

What causes severe malaria and its complications in children? Lessons learned over the past 15 years

(2019) Andrea L. Conroy et al.   BMC Medicine

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

(2019) Monique R. Heitmeier et al.   PLoS One

Setting the scene and generating evidence for malaria elimination in Southern Mozambique

(2019) Pedro Aide et al.   MALARIA JOURNAL

Recent Advances in System Based Study for Anti-Malarial Drug Development Process

(2019) Brijesh S. Yadav et al.   CURRENT PHARMACEUTICAL DESIGN

Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives

(2018) LUIZ C.S. PINHEIRO et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

1,2-Diphenoxiethane salts as potent antiplasmodial agents

(2018) Santiago Schiafino-Ortega et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drugs in Development for Malaria

(2018) Elizabeth A. Ashley et al.   DRUGS

A systems biology approach to antimalarial drug discovery

(2018) Wilian Augusto Cortopassi et al.   Expert Opinion on Drug Discovery

Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity inPlasmodium falciparummembranes

(2018) James E. O. Rosling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

(2018) Nishanth Kandepedu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

(2018) Alejandro Llanos-Cuentas et al.   LANCET INFECTIOUS DISEASES

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

(2018) Dora Posfai et al.   PLoS Pathogens

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

(2018) Christine Moore Sheridan et al.   MALARIA JOURNAL

Comprehensive review on various strategies for antimalarial drug discovery

(2017) Mitali Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combating multidrug-resistant Plasmodium falciparum malaria

(2017) Aung Myint Thu et al.   FEBS Journal

Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation

(2017) Edgar Deu   FEBS Journal

Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges

(2017) Kuldeep K. Roy   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evaluating Cinchona bark and quinine for treating and preventing malaria

(2017) G Gachelin et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

New developments in anti-malarial target candidate and product profiles

(2017) Jeremy N. Burrows et al.   MALARIA JOURNAL

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

(2017) Ivy Owusu-Boateng et al.   MALARIA JOURNAL

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

(2017) Blessing Aderibigbe   MOLECULES

Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733

(2017) Emily D. Crawford et al.   PLoS One

Is the Mitochondrion a Good Malaria Drug Target?

(2017) Christopher D. Goodman et al.   TRENDS IN PARASITOLOGY

Esterase mutation is a mechanism of resistance to antimalarial compounds

(2017) Eva S. Istvan et al.   Nature Communications

Antimalarial Drug Resistance: A Threat to Malaria Elimination

(2017) Didier Menard et al.   Cold Spring Harbor Perspectives in Medicine

Prevalence of mutations linked to antimalarial resistance in Plasmodium falciparum from Chhattisgarh, Central India: A malaria elimination point of view

(2017) Priyanka Patel et al.   Scientific Reports

Historical Review: Problematic Malaria Prophylaxis with Quinine

(2016) G. Dennis Shanks   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

GLUT1-mediated glucose uptake plays a crucial role duringPlasmodiumhepatic infection

(2016) Patrícia Meireles et al.   CELLULAR MICROBIOLOGY

Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria?

(2016) Tiphaine Gaillard et al.   MALARIA JOURNAL

Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats

(2016) Greanious Alfred Mavondo et al.   MALARIA JOURNAL

Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

(2016) Tiphaine Gaillard et al.   MALARIA JOURNAL

Pyrimidine-based antimalarials: design strategies and antiplasmodial effects

(2016) Kamaljit Singh et al.   MedChemComm

Alternatives to currently used antimalarial drugs: in search of a magic bullet

(2016) Akshaya Srikanth Bhagavathula et al.   Infectious Diseases of Poverty

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

(2016) Benjamin K. Dickerman et al.   Scientific Reports

Supporting malaria elimination with 21st century antimalarial agent drug discovery

(2015) Thierry T. Diagana   DRUG DISCOVERY TODAY

A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

(2015) Rou Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Tetracyclines in malaria

(2015) Tiphaine Gaillard et al.   MALARIA JOURNAL

Amodiaquine-induced reproductive toxicity in adult male rats

(2015) Yan-Ru Niu et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Progress with viral vectored malaria vaccines: A multi-stage approach involving “unnatural immunity”

(2015) Katie J. Ewer et al.   VACCINE

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum

(2015) Rosa V. Marchetti et al.   Nature Communications

New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

(2014) Sharon Wein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

(2014) Eamon Comer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mefloquine safety and tolerability in pregnancy: a systematic literature review

(2014) Raquel González et al.   MALARIA JOURNAL

A Chemical Proteomics Approach for the Search of Pharmacological Targets of the Antimalarial Clinical Candidate Albitiazolium in Plasmodium falciparum Using Photocrosslinking and Click Chemistry

(2014) Diana Marcela Penarete-Vargas et al.   PLoS One

New insight-guided approaches to detect, cure, prevent and eliminate malaria

(2014) Sushil Kumar et al.   PROTOPLASMA

Comparative benefit of malaria chemoprophylaxis modelled in United Kingdom travellers

(2014) Stephen Toovey et al.   Travel Medicine and Infectious Disease

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives

(2013) Minghao Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malaria and artemisinin derivatives: an updated review

(2013) Muhammad Ansari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

Antimalarial drug discovery – the path towards eradication

(2013) JEREMY N BURROWS et al.   PARASITOLOGY

Pumped up: reflections on PfATP6 as the target for artemisinins

(2013) Sanjeev Krishna et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Primaquine radical cure of Plasmodium vivax: a critical review of the literature

(2012) George K John et al.   MALARIA JOURNAL

Review of pyronaridine anti-malarial properties and product characteristics

(2012) Simon L Croft et al.   MALARIA JOURNAL

A role for heparan sulfate proteoglycans inPlasmodium falciparumsporozoite invasion of anopheline mosquito salivary glands

(2011) Jennifer S. Armistead et al.   BIOCHEMICAL JOURNAL

Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells

(2011) Wang Nguitragool et al.   CELL

Falcipains, Plasmodium falciparum Cysteine Proteases as Key Drug Targets Against Malaria

(2011) C. Teixeira et al.   CURRENT MEDICINAL CHEMISTRY

The Plasmodium falciparum-infected red blood cell

(2011) Leann Tilley et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein translation in Plasmodium parasites

(2011) Katherine E. Jackson et al.   TRENDS IN PARASITOLOGY

Complicações oculares da terapêutica com a cloroquina e derivados

(2010) Augusto Cézar Lacava   ARQUIVOS BRASILEIROS DE OFTALMOLOGIA

The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages

(2010) Sandrine Déchamps et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base

(2009) Olivier Bouchaud et al.   MALARIA JOURNAL

Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte

(2009) Sven Bietz et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Malarial Drug Target Plasmodium falciparum 1-Deoxy-D-Xylulose-5- Phosphate Reductoisomerase (PfDXR): Development of a 3-D Model for Identification of Novel, Structural and Functional Features and for Inhibitor Screening (Supplementary Information)

(2009) Jessica Goble et al.   PROTEIN AND PEPTIDE LETTERS

Irreversible effect of cysteine protease inhibitors on the release of malaria parasites from infected erythrocytes

(2008) Svetlana Glushakova et al.   CELLULAR MICROBIOLOGY

Novel Molecular Targets for Antimalarial Drug Development

(2008) Nitendra K. Sahu et al.   Chemical Biology & Drug Design

Artemisinin-based combination therapy for uncomplicated malaria in sub-Saharan Africa: the efficacy, safety, resistance and policy implementation since Abuja 2000

(2008) Anayo Ogbonna et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE