Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

(2016) Wesley C. Van Voorhis et al.   PLoS Pathogens

Metabolic Dysregulation Induced inPlasmodium falciparumby Dihydroartemisinin and Other Front-Line Antimalarial Drugs

(2015) Simon A. Cobbold et al.   JOURNAL OF INFECTIOUS DISEASES

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Atovaquone Tolerance in Plasmodium falciparum Parasites Selected for High-Level Resistance to a Dihydroorotate Dehydrogenase Inhibitor

(2014) Jennifer L. Guler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Plasmodium falciparum Transfected with Ultra Bright NanoLuc Luciferase Offers High Sensitivity Detection for the Screening of Growth and Cellular Trafficking Inhibitors

(2014) Mauro F. Azevedo et al.   PLoS One

Membrane transport in the malaria parasite and its host erythrocyte

(2013) Kiaran Kirk et al.   BIOCHEMICAL JOURNAL

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum

(2012) Sandra Hasenkamp et al.   MALARIA JOURNAL

Systematic Analysis of FKBP Inducible Degradation Domain Tagging Strategies for the Human Malaria Parasite Plasmodium falciparum

(2012) Mauro Ferreira de Azevedo et al.   PLoS One

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

(2012) G. A. Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells

(2011) Wang Nguitragool et al.   CELL

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

(2011) Suresh M. Ganesan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

Methionine transport in the malaria parasite Plasmodium falciparum

(2010) Simon A. Cobbold et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Novel Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

(2010) Michael L. Booker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell-Based High-Throughput Screen Validates the Plasmodial Surface Anion Channel As an Antimalarial Target

(2010) A. D. Pillai et al.   MOLECULAR PHARMACOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

The Human Malaria ParasitePlasmodium falciparumIs Not Dependent on Host Coenzyme A Biosynthesis

(2009) Christina Spry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

(2009) Xiaoyi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY