Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733

MinorityReport, software for generalized analysis of causal genetic variants

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Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

(2016) Ebere Sonoiki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1

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Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum

(2016) Stanislaw J. Gabryszewski et al.   MOLECULAR BIOLOGY AND EVOLUTION

CRISPR-Cas9-modifiedpfmdr1protectsPlasmodium falciparumasexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

(2016) Caroline L. Ng et al.   MOLECULAR MICROBIOLOGY

A redesigned CRISPR/Cas9 system for marker-free genome editing in Plasmodium falciparum

(2016) Junnan Lu et al.   Parasites & Vectors

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

(2016) Gregory LaMonte et al.   mBio

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

(2016) Abhisheka Bansal et al.   mBio

A broad analysis of resistance development in the malaria parasite

(2016) Victoria C. Corey et al.   Nature Communications

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

Rapid Generation of Marker-Free P. falciparum Fluorescent Reporter Lines Using Modified CRISPR/Cas9 Constructs and Selection Protocol

(2016) Catherin Marin Mogollon et al.   PLoS One

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

(2015) Natalie Jane Spillman et al.   International Journal for Parasitology-Drugs and Drug Resistance

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

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A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

(2014) Wesley Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum

(2014) A. H. Lee et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

(2014) Jeffrey C Wagner et al.   NATURE METHODS

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium

(2014) María Belén Jiménez-Díaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity

(2013) Laura A. Kirkman et al.   NUCLEIC ACIDS RESEARCH

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum

(2012) Florence Caro et al.   MALARIA JOURNAL

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

(2012) Judith Straimer et al.   NATURE METHODS

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH