Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

Glucose Transporters and Virulence in Leishmania mexicana

(2018) Xiuhong Feng et al.   mSphere

Malaria Parasite Liver Infection and Exoerythrocytic Biology

(2017) Ashley M. Vaughan et al.   Cold Spring Harbor Perspectives in Medicine

Targeting pathogen metabolism without collateral damage to the host

(2017) Jurgen R. Haanstra et al.   Scientific Reports

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

GLUT1-mediated glucose uptake plays a crucial role duringPlasmodiumhepatic infection

(2016) Patrícia Meireles et al.   CELLULAR MICROBIOLOGY

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

(2016) Richard C. Hresko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenylm-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site

(2016) Ogooluwa A. Ojelabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

(2016) Khyati Kapoor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir

(2015) Thomas E. Kraft et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Structure and mechanism of the mammalian fructose transporter GLUT5

(2015) Norimichi Nomura et al.   NATURE

Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4

(2015) Thomas E. Kraft et al.   PROTEIN SCIENCE

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

(2015) Diana Ortiz et al.   PLoS One

Isoform-selective Inhibition of Facilitative Glucose Transporters

(2014) Richard C. Hresko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GLUT1 deficiency syndrome: An update

(2013) D. Gras et al.   REVUE NEUROLOGIQUE

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle

(2011) Ksenija Slavic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling

(2011) Baichen Zhang et al.   BIOCHEMISTRY

HIV Protease Inhibitors Act as Competitive Inhibitors of the Cytoplasmic Glucose Binding Site of GLUTs with Differing Affinities for GLUT1 and GLUT4

(2011) Richard C. Hresko et al.   PLoS One

A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs

(2010) Martin Blume et al.   FASEB JOURNAL

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Malaria Parasite Pre-Erythrocytic Stage Infection: Gliding and Hiding

(2008) Ashley M. Vaughan et al.   Cell Host & Microbe

The Inhibitory Effect of 2-Halo Derivatives of D-Glucose on Glycolysis and on the Proliferation of the Human Malaria Parasite Plasmodium falciparum

(2008) D. A. van Schalkwyk et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS