Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

Oncogene Mimicry as a Mechanism of Primary Resistance to BRAF Inhibitors

(2014) Martin L. Sos et al.   Cell Reports

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling

(2013) A. Schroeder et al.   CANCER RESEARCH

JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

(2013) P. Kroon et al.   CANCER RESEARCH

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

(2013) F Hayakawa et al.   Blood Cancer Journal

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA

(2012) Olga A. Timofeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies

(2012) Pasquale Sansone et al.   JOURNAL OF CLINICAL ONCOLOGY

Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2012) Bikash Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Another Brick in the Wall. Validation of the σ1 Receptor 3D Model by Computer-Assisted Design, Synthesis, and Activity of New σ1 Ligands

(2012) Erik Laurini et al.   MOLECULAR PHARMACEUTICS

Transcriptional and Non-Transcriptional Functions of PPARβ/δ in Non-Small Cell Lung Cancer

(2012) Davide Genini et al.   PLoS One

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct reprogramming of stem cell properties in colon cancer cells by CD44

(2011) Ying-Jhen Su et al.   EMBO JOURNAL

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

The molecular basis of IGF-II/IGF2R recognition: a combined molecular dynamics simulation, free-energy calculation and computational alanine scanning study

(2011) Jingjing Guo et al.   JOURNAL OF MOLECULAR MODELING

Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor

(2011) Erik Laurini et al.   ACS Medicinal Chemistry Letters

Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase

(2010) Gabriele Giliberti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells

(2009) Sara Napoli et al.   EMBO JOURNAL

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

(2008) Sergei Grivennikov et al.   CANCER CELL

Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation

(2008) H. R. Qin et al.   CANCER RESEARCH

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2008) Steven Fletcher et al.   ChemMedChem

Paradigm shifts in the cell biology of STAT signaling

(2008) Pravin B. Sehgal   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY